Cursed Buttercup + Penicillin G
Penicillin G brand name: Pfizerpen.
We found no known interaction between Cursed Buttercup and Penicillin G in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Cursed Buttercup and Penicillin G
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Penicillin G and Cursed Buttercup in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Cursed Buttercup at all — not against Penicillin G, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Cursed Buttercup safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Cursed Buttercup in Pregnancy & Breastfeeding
When used orally or topically. Oral use of cursed buttercup might stimulate uterine activity.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Penicillin G
This page covers Cursed Buttercup only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Penicillin G page lists 56 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Asarabacca (major), Siberian Cocklebur (major), Aristolochia (moderate) and Bacillus Coagulans (moderate).
By severity: 3 major · 42 moderate · 11 minor.
From our pharmacist’s overview on the Penicillin G page
“My concern with penicillin G (Pfizerpen), an injectable antibiotic reserved for serious infections such as syphilis and endocarditis, centers on a few supplements that deserve genuine respect. Siberian cocklebur and asarabacca can each harm the kidneys, extra strain nobody fighting a severe infection needs, while activated charcoal can…”
Reviewed by 2 · Jul 18, 2026
Where Cursed Buttercup and Penicillin G Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,248 of 1,452 supplements looked up here in the last 7 days
#1,086 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cursed Buttercup reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Cursed Buttercup and Penicillin G records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Cursed Buttercup
What is Cursed Buttercup?
- Traditional topical use for skin and joint complaints
- Folk remedy for warts and skin growths (as a counterirritant)
- Historical use for fevers
- Traditional use for swelling or pain
Cursed Buttercup is a toxic wetland plant that can cause severe skin blistering and dangerous poisoning if eaten. It is not a safe or proven dietary supplement, and there is no reliable evidence supporting any medicinal use. Do not take it internally or apply it to your skin without medical supervision—in practice, it is best avoided entirely.
Ranunculus sceleratus · Ranunculaceae · Whole plant (leaves, stems, flowers); historically used topically · Fresh plant poultice or crushed leaves in traditional practice; not sold as a standardized supplement
An interaction check asks whether these two react with each other — it does not ask whether Cursed Buttercup is a good idea for someone in your situation. Here is what our Cursed Buttercup record says about it on its own.
Cursed Buttercup: dosing
There is no established or safe dose of Cursed Buttercup. It is not a recognized dietary supplement, and no reputable product provides standardized, tested amounts.Because the plant is toxic, the safest approach is to not use it at all.
From our Cursed Buttercup monograph — the full record covers uses, side effects and every documented interaction.
About Penicillin G (Potassium, Sodium) Injection
What Is Penicillin G (Potassium, Sodium) Injection Used For?
Brand name: Pfizerpen
Penicillin G Potassium for Injection is used to treat serious infections caused by bacteria that are susceptible to penicillin. It covers a wide range of conditions, including bloodstream infections (septicemia), meningitis, pneumonia, endocarditis (heart valve infection), and pericarditis (infection around the heart).
It is also used for infections such as syphilis (including neurosyphilis and congenital syphilis), anthrax, diphtheria, botulism, tetanus, gas gangrene, disseminated gonococcal infections, listeria infections, and rat-bite fever, among others. Some uses are as adjunctive therapy — meaning penicillin G supports, but does not replace, other treatments like antitoxins.
Other Drugs & Cursed Buttercup
Browse every other medication we’ve checked against Cursed Buttercup — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Cursed Buttercup against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Aspirin ›
- Abemaciclib ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Warfarin Sodium ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Amitriptyline ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Azithromycin ›
- Acyclovir ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Cursed Buttercup list.
Cursed Buttercup References
The 2 references that drive our Cursed Buttercup monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Penicillin G Is Linked to Lower Levels of 7 Nutrients
Natural Medicines records Penicillin G as a medicine that can lower these. This is not an interaction with Cursed Buttercup — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Penicillin G nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Cursed Buttercup and Penicillin G Together: Common Questions
Is it safe to take Cursed Buttercup with Penicillin G?
Does Penicillin G interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Penicillin G and Cursed Buttercup?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.