Drug & supplement interaction

Cypress + Imiquimod

Imiquimod brand names: Aldara, Zyclara, Vyloma.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Cypress and Imiquimod in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share

Facebook Post Reddit Email

On this page

Interaction report

Cypress and Imiquimod

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Imiquimod and Cypress in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cypress safety at a glance

Cypress overall Use caution Often used externally or in aromatherapy; the essential oil should not be swallowed and human safety data are limited.

Pregnancy Avoid Not enough safety information, so it is best to avoid use during pregnancy.

Breastfeeding Avoid Not enough safety information, so it is best to avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Imiquimod and Cypress? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Imiquimod

Interactions in our licensed database are recorded against drug classes, not just single drug names. Imiquimod is filed under a single classification — topical drugs. Cypress has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Imiquimod’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Cypress Does Interact With Other Medications

Cypress has 122 moderate known drug interactions in our database — Imiquimod isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Imiquimod)

Taking anything else?

Check Another of Your Medications Against Cypress

Covers the 2,830 medications we’ve checked against Cypress. Pick one to open its full report.

What to actually watch for

What Cypress Itself Has Been Linked To

This is not an interaction — nothing below involves Imiquimod. It is the side-effect record for Cypress on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Cypress, this list is the first place to look.

A skin rash Additional detail
“Airborne cypress pollen is a common cause of allergy-related respiratory and ocular symptoms in some people. A case of allergic contact dermatitis to the resin-impregnated leaves of a cypress tree has occurred in a patient with a history of cutaneous reactions to adhesive bandages, likely due to a cross-sensitivity with colophonium.”

Cypress · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).
5 sources cited

46912. Geller-Bernstein, C., Waisel, Y., and Lahoz, C. Environment and sensitization to cypress in Israel. Allerg.Immunol.(Paris) 2000;32(3):92-93.

46915. Papa, G., Romano, A., Quaratino, D., Di Fonso, M., Viola, M., Artesani, M. C., Sernia, S., Di Gioacchino, M., and Venuti, A. Prevalence of sensitization to Cupressus sempervirens: a 4-year retrospective study. Sci.Total Environ. 4-10-2001;270(1-3):83-87. PubMed

46925. Togawa, A., Panzani, R. C., Garza, M. A., Kishikawa, R., Goldblum, R. M., and Midoro-Horiuti, T. Identification of italian cypress (Cupressus sempervirens) pollen allergen Cup s 3 using homology and cross-reactivity. Ann.Allergy Asthma Immunol. 2006;97(3 PubMed

46930. De Luca, A., Graziani, E., Anticoli, S., Simeoni, S., Terzano, C., and Mannino, F. Respiratory allergy to Cupressus sempervirens in Rome. Allergol.Immunopathol.(Madr.) 1997;25(5):229-232.

106005. Samaran Q, Clark E, Dereure O, Raison-Peyron N. Allergic contact dermatitis to Cupressus sempervirens resin and cross-reaction with colophonium. Contact Dermatitis 2020;83(1):33-35.

Everything above comes from the Natural Medicines adverse-effect record for Cypress — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Imiquimod’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Imiquimod column appears here.

Everything else you take

See Every Supplement That Interacts With Imiquimod

This page covers Cypress only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Imiquimod page lists 3 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).

By severity: 2 moderate · 1 minor.

From our pharmacist’s overview on the Imiquimod page

“Imiquimod (Aldara, Zyclara, Vyloma) is a cream for warts, precancerous spots, and certain skin cancers, and its supplement list is short and workable for most people. Only 3 ingredients are on file, none rated major, and all involve products applied to the skin rather than swallowed.”

Reviewed by 2 · Jul 18, 2026

Open the Imiquimod interaction page

One more smart check

Taking Cypress as Part of a Dietary Supplement Product? Check It for Interactions

We hold 13 real supplement products containing Cypress, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cypress. Even though Cypress itself has no known interaction with Imiquimod, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Cypress and Imiquimod Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cypress

Top half

#674 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Imiquimod

Steady interest

#1,576 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cypress reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Cypress and Imiquimod records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Cypress

What is Cypress?

Circulation and varicose veins
Coughs and respiratory complaints
Excess sweating
Skin and minor wounds
Aromatherapy for relaxation

Cypress comes from the Mediterranean cypress tree and is most often used as an essential oil in aromatherapy or skin care, and traditionally for circulation and respiratory complaints. High-quality human evidence for these uses is very limited, so it should not replace proven treatments. The essential oil is for external use only and should be diluted, and you should talk with your pharmacist or doctor before using it.

Cupressus sempervirens · Cupressaceae · Cones (galbuli), leaves/needles, and essential oil · Essential oil, extracts, capsules, and dried plant material

An interaction check asks whether these two react with each other — it does not ask whether Cypress is a good idea for someone in your situation. Here is what our Cypress record says about it on its own.

Cypress: dosing

There is no standardized or well-established dose for cypress. Products vary widely in strength and form, so the right amount depends on how it is being used.For essential oil used on the skin, it should always be diluted in a carrier oil rather than applied straight. Do not take cypress essential oil by mouth.

From our Cypress monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cypress monograph & all interactions

Medication

About Imiquimod Topical

What Is Imiquimod Topical Used For?

Brand names: Aldara, Zyclara, Vyloma

Imiquimod cream is used to treat three skin conditions in adults: actinic keratoses (rough, scaly patches on the skin caused by sun damage) on the face or scalp; superficial basal cell carcinoma (a type of skin cancer) on the trunk, neck, or limbs when surgery is not the best option; and external genital and perianal warts (condyloma acuminata) in patients 12 years and older.

It is not effective for molluscum contagiosum in children ages 2–12, and it has not been proven safe or effective in people with weakened immune systems. It should not be used for warts inside the urethra, vagina, cervix, rectum, or anal canal.

Most-Reported Side Effects for Imiquimod

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Erythema 183 reports

Fatigue 179 reports

Nausea 114 reports

Influenza like illness 102 reports

Application site erythema 100 reports

See full Imiquimod Topical drug information

Keep checking

Other Drugs & Cypress

Browse every other medication we’ve checked against Cypress — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

122Moderate

0Minor

2,707No known interaction

122 Moderate 2,707 No interaction

Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Cypress page.

No interaction 2,707 drugs checked — show the list

We also checked Cypress against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Cypress list.

See the full Cypress interactions page

See every supplement checked against Imiquimod, ranked by severity

Evidence & sources

Cypress References

The 7 references that drive our Cypress monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Geller-Bernstein, C., Waisel, Y., and Lahoz, C. Environment and sensitization to cypress in Israel. Allerg.Immunol.(Paris) 2000;32(3):92-93.
Papa, G., Romano, A., Quaratino, D., Di Fonso, M., Viola, M., Artesani, M. C., Sernia, S., Di Gioacchino, M., and Venuti, A. Prevalence of sensitization to Cupressus sempervirens: a 4-year retrospective study. Sci.Total Environ. 4-10-2001;270(1-3):83-87. PubMed
Togawa, A., Panzani, R. C., Garza, M. A., Kishikawa, R., Goldblum, R. M., and Midoro-Horiuti, T. Identification of italian cypress (Cupressus sempervirens) pollen allergen Cup s 3 using homology and cross-reactivity. Ann.Allergy Asthma Immunol. 2006;97(3 PubMed
De Luca, A., Graziani, E., Anticoli, S., Simeoni, S., Terzano, C., and Mannino, F. Respiratory allergy to Cupressus sempervirens in Rome. Allergol.Immunopathol.(Madr.) 1997;25(5):229-232.
Ulusal BG, Arikan S, Durusoy C. Anticoagulant effect of Cupressus sempervirens. Phytother Res. 2007 Nov;21(11):1116.
Samaran Q, Clark E, Dereure O, Raison-Peyron N. Allergic contact dermatitis to Cupressus sempervirens resin and cross-reaction with colophonium. Contact Dermatitis 2020;83(1):33-35.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cypress and Imiquimod Together: Common Questions

Is it safe to take Cypress with Imiquimod?

We do not list a known interaction between Cypress and Imiquimod. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Cypress and Imiquimod combination checked?

Interactions in our licensed database are recorded against drug classes. Imiquimod is filed under 1 classification, and Cypress has documented interactions with 1 drug class — none of Imiquimod's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Cypress interact with any other medications?

Yes. Cypress has 122 documented drug interactions in our database — Imiquimod is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Imiquimod interact with any supplements?

Yes. Imiquimod has documented interactions with 3 supplements in our database — Cypress is not one of them. The Imiquimod interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cypress monograph Uses, safety profile, and every drug interaction in one place Imiquimod Topical drug information The full plain-English guide to this medication Imiquimod supplement interactions Every supplement checked against Imiquimod, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Imiquimod and Cypress?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.