Drug & supplement interaction

Cypress + Ursodiol

Ursodiol brand name: Actigall.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Cypress and Ursodiol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Cypress and Ursodiol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ursodiol and Cypress in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cypress safety at a glance

Cypress overall Use caution Often used externally or in aromatherapy; the essential oil should not be swallowed and human safety data are limited.
Pregnancy Avoid Not enough safety information, so it is best to avoid use during pregnancy.
Breastfeeding Avoid Not enough safety information, so it is best to avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ursodiol and Cypress? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ursodiol

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ursodiol is filed under a single classification — oral drugs. Cypress has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Ursodiol’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Cypress Does Interact With Other Medications

Cypress has 122 moderate known drug interactions in our database — Ursodiol isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Ursodiol)
Taking anything else?

Check Another of Your Medications Against Cypress

Covers the 2,830 medications we’ve checked against Cypress. Pick one to open its full report.

What to actually watch for

What Cypress Itself Has Been Linked To

This is not an interaction — nothing below involves Ursodiol. It is the side-effect record for Cypress on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Cypress, this list is the first place to look.

  • A skin rash Additional detail

    “Airborne cypress pollen is a common cause of allergy-related respiratory and ocular symptoms in some people. A case of allergic contact dermatitis to the resin-impregnated leaves of a cypress tree has occurred in a patient with a history of cutaneous reactions to adhesive bandages, likely due to a cross-sensitivity with colophonium.”

    Cypress · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    5 sources cited
    1. 46912. Geller-Bernstein, C., Waisel, Y., and Lahoz, C. Environment and sensitization to cypress in Israel. Allerg.Immunol.(Paris) 2000;32(3):92-93.
    2. 46915. Papa, G., Romano, A., Quaratino, D., Di Fonso, M., Viola, M., Artesani, M. C., Sernia, S., Di Gioacchino, M., and Venuti, A. Prevalence of sensitization to Cupressus sempervirens: a 4-year retrospective study. Sci.Total Environ. 4-10-2001;270(1-3):83-87. PubMed
    3. 46925. Togawa, A., Panzani, R. C., Garza, M. A., Kishikawa, R., Goldblum, R. M., and Midoro-Horiuti, T. Identification of italian cypress (Cupressus sempervirens) pollen allergen Cup s 3 using homology and cross-reactivity. Ann.Allergy Asthma Immunol. 2006;97(3 PubMed
    4. 46930. De Luca, A., Graziani, E., Anticoli, S., Simeoni, S., Terzano, C., and Mannino, F. Respiratory allergy to Cupressus sempervirens in Rome. Allergol.Immunopathol.(Madr.) 1997;25(5):229-232.
    5. 106005. Samaran Q, Clark E, Dereure O, Raison-Peyron N. Allergic contact dermatitis to Cupressus sempervirens resin and cross-reaction with colophonium. Contact Dermatitis 2020;83(1):33-35.

Everything above comes from the Natural Medicines adverse-effect record for Cypress — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Ursodiol’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Ursodiol column appears here.

From our Q&A

Questions About Cypress or Ursodiol

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Cypress or Ursodiol, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Ursodiol

This page covers Cypress only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ursodiol page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Ursodiol page

“Ursodiol (Actigall) has to be absorbed to do its job, whether that job is dissolving gallstones or protecting a liver with primary biliary cholangitis, and all 17 supplements on this page can interfere with exactly that. I'd treat these pairings with genuine care.”

Reviewed by 2 · Jul 18, 2026

Open the Ursodiol interaction page

One more smart check

Taking Cypress as Part of a Dietary Supplement Product? Check It for Interactions

We hold 13 real supplement products containing Cypress, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cypress. Even though Cypress itself has no known interaction with Ursodiol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Cypress and Ursodiol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cypress
Top half

#676 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ursodiol
Steady interest

#1,819 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cypress reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Cypress and Ursodiol records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cypress

What is Cypress?

  • Circulation and varicose veins
  • Coughs and respiratory complaints
  • Excess sweating
  • Skin and minor wounds
  • Aromatherapy for relaxation

Cypress comes from the Mediterranean cypress tree and is most often used as an essential oil in aromatherapy or skin care, and traditionally for circulation and respiratory complaints. High-quality human evidence for these uses is very limited, so it should not replace proven treatments. The essential oil is for external use only and should be diluted, and you should talk with your pharmacist or doctor before using it.

Cupressus sempervirens · Cupressaceae · Cones (galbuli), leaves/needles, and essential oil · Essential oil, extracts, capsules, and dried plant material

An interaction check asks whether these two react with each other — it does not ask whether Cypress is a good idea for someone in your situation. Here is what our Cypress record says about it on its own.

Cypress: dosing

There is no standardized or well-established dose for cypress. Products vary widely in strength and form, so the right amount depends on how it is being used.For essential oil used on the skin, it should always be diluted in a carrier oil rather than applied straight. Do not take cypress essential oil by mouth.

From our Cypress monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cypress monograph & all interactions
Medication

About Ursodiol

What Is Ursodiol Used For?

Brand name: Actigall

Ursodiol capsules (including Reltone, Ursolign, and generic ursodiol capsules) are used to dissolve certain types of gallstones — specifically small, non-calcified cholesterol stones — in people who cannot have or prefer not to have gallbladder surgery. Capsules are also used to prevent gallstones from forming in people who are losing weight rapidly.

Ursodiol tablets — including Urso 250, Urso Forte, and generic ursodiol tablets — are indicated for the treatment of primary biliary cholangitis (PBC), a chronic liver disease that damages the bile ducts inside the liver.

Most-Reported Side Effects for Ursodiol

From FAERS, the FDA’s public side-effect reporting system (21,651 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Pruritus 1,299 reports
Diarrhea 1,223 reports
Fatigue 1,093 reports
Nausea 1,062 reports
Fever 990 reports
See full Ursodiol drug information
Keep checking

Other Drugs & Cypress

Browse every other medication we’ve checked against Cypress — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Cypress page.

No interaction 2,707 drugs checked — show the list

We also checked Cypress against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Cypress list.

See the full Cypress interactions page
See every supplement checked against Ursodiol, ranked by severity
Evidence & sources

Cypress References

The 7 references that drive our Cypress monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Geller-Bernstein, C., Waisel, Y., and Lahoz, C. Environment and sensitization to cypress in Israel. Allerg.Immunol.(Paris) 2000;32(3):92-93.
  3. Papa, G., Romano, A., Quaratino, D., Di Fonso, M., Viola, M., Artesani, M. C., Sernia, S., Di Gioacchino, M., and Venuti, A. Prevalence of sensitization to Cupressus sempervirens: a 4-year retrospective study. Sci.Total Environ. 4-10-2001;270(1-3):83-87. PubMed
  4. Togawa, A., Panzani, R. C., Garza, M. A., Kishikawa, R., Goldblum, R. M., and Midoro-Horiuti, T. Identification of italian cypress (Cupressus sempervirens) pollen allergen Cup s 3 using homology and cross-reactivity. Ann.Allergy Asthma Immunol. 2006;97(3 PubMed
  5. De Luca, A., Graziani, E., Anticoli, S., Simeoni, S., Terzano, C., and Mannino, F. Respiratory allergy to Cupressus sempervirens in Rome. Allergol.Immunopathol.(Madr.) 1997;25(5):229-232.
  6. Ulusal BG, Arikan S, Durusoy C. Anticoagulant effect of Cupressus sempervirens. Phytother Res. 2007 Nov;21(11):1116.
  7. Samaran Q, Clark E, Dereure O, Raison-Peyron N. Allergic contact dermatitis to Cupressus sempervirens resin and cross-reaction with colophonium. Contact Dermatitis 2020;83(1):33-35.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cypress and Ursodiol Together: Common Questions

Is it safe to take Cypress with Ursodiol?
We do not list a known interaction between Cypress and Ursodiol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Cypress and Ursodiol combination checked?
Interactions in our licensed database are recorded against drug classes. Ursodiol is filed under 1 classification, and Cypress has documented interactions with 1 drug class — none of Ursodiol's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Cypress interact with any other medications?
Yes. Cypress has 122 documented drug interactions in our database — Ursodiol is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ursodiol interact with any supplements?
Yes. Ursodiol has documented interactions with 17 supplements in our database — Cypress is not one of them. The Ursodiol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cypress monograph Uses, safety profile, and every drug interaction in one place Ursodiol drug information The full plain-English guide to this medication Ursodiol supplement interactions Every supplement checked against Ursodiol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ursodiol and Cypress?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.