Drug & supplement interaction

Dandelion + Diphenhydramine, Zinc Oxide

Diphenhydramine, Zinc Oxide brand name: Caladryl Clear.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Dandelion and Diphenhydramine, Zinc Oxide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Dandelion and Diphenhydramine, Zinc Oxide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Diphenhydramine, Zinc Oxide and Dandelion in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Dandelion safety at a glance

Dandelion overall Use caution Generally well tolerated as food, but supplement-strength doses are less studied and may cause allergy or stomach upset.
Pregnancy Use caution Limited safety data; avoid concentrated supplements and check with your doctor before use.
Breastfeeding Use caution Not enough reliable information on safety while breastfeeding, so caution is advised.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Diphenhydramine, Zinc Oxide and Dandelion? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Diphenhydramine, Zinc Oxide

Interactions in our licensed database are recorded against drug classes, not just single drug names. Diphenhydramine, Zinc Oxide is filed under 2 classifications — cytochrome p450 2d6 (cyp2d6) inhibitors, topical drugs. Dandelion has documented interactions with 7 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and cytochrome p450 1a2 (cyp1a2) substrates (moderate) — and none of Diphenhydramine, Zinc Oxide’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Dandelion Does Interact With Other Medications

Dandelion has 457 moderate known drug interactions in our database — Diphenhydramine, Zinc Oxide isn’t one of them. If you take anything else, check it against the full list below.

Moderate 457 No known interaction 2,373 (incl. Diphenhydramine, Zinc Oxide)
Taking anything else?

Check Another of Your Medications Against Dandelion

Covers the 2,830 medications we’ve checked against Dandelion. Pick one to open its full report.

What to actually watch for

What Dandelion Itself Has Been Linked To

This is not an interaction — nothing below involves Diphenhydramine, Zinc Oxide. It is the side-effect record for Dandelion on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Dandelion, this list is the first place to look. 7 entries are worth acting on rather than waiting out — marked below.

  • A bowel blockage Worth acting on Additional detail

    “Gastrointestinal symptoms, including stomach discomfort, diarrhea, and heartburn, have been reported following oral use of dandelion. A case of intestinal blockage has been reported for a patient who ingested a large amount of dandelion greens three weeks after undergoing a stomach operation.”

    Dandelion · Natural Medicines adverse-effect record, reported in diarrhea.

    4 sources cited
    1. 19146. Cuzzolin L, Zaffani S, and Benoni G. Safety implications regarding use of phytomedicines. Eur.J Clin Pharmacol. 2006;62:37-42. PubMed
    2. 36931. Posadzki, P., Watson, L. K., and Ernst, E. Adverse effects of herbal medicines: an overview of systematic reviews. Clin Med 2013;13(1):7-12. PubMed
    3. 46981. Collins JM and Miller DR. Dandelion green bezoar following antrectomy and vagotomy - case report. J Kansas Med Soc 1966;67(6):303-304.
    4. 46959. Catania, M. A., Oteri, A., Caiello, P., Russo, A., Salvo, F., Giustini, E. S., Caputi, A. P., and Polimeni, G. Hemorrhagic cystitis induced by an herbal mixture. South.Med.J. 2010;103(1):90-92. PubMed
  • Fainting / An irregular heartbeat Worth acting on Additional detail

    “In one report, a 39-year-old obese woman developed palpitations and syncope after taking a weight loss supplement containing a combination of dandelion, bladderwrack, and boldo for 3 weeks. The patient was found to have prolonged QT-interval on ECG and frequent episodes of sustained polymorphic ventricular tachycardia.”

    Dandelion · Natural Medicines adverse-effect record, reported in obesity.

    1 source cited
    1. 14321. Agarwal SC, Crook JR, Pepper CB. Herbal remedies -- how safe are they? A case report of polymorphic ventricular tachycardia/ventricular fibrillation induced by herbal medication used for obesity. Int J Cardiol 2006;106:260-1. PubMed
  • Wheezing Worth acting on Additional detail

    “Orally, products containing dandelion pollen can cause allergic reactions, including anaphylaxis. Also, rhinoconjunctivitis and asthma have been reported after handling products such as bird feed containing dandelion and other herbs, with reported positive skin tests for dandelion hypersensitivity. Dandelion pollen may cause pollinosis, such as allergic rhinitis and conjunctivitis.”

    Dandelion · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    6 sources cited
    1. 13479. Chivato T, Juan F, Montoro A, Laguna R. Anaphylaxis induced by ingestion of a pollen compound. J Investig Allergol Clin Immunol 1996;6:208-9.
    2. 13480. Cohen SH, Yunginger JW, Rosenberg N, Fink JN. Acute allergic reaction after composite pollen ingestion. J Allergy Clin Immunol 1979;64:270-4. PubMed
    3. 46948. Rodriguez, B., Rodriguez, A., de Barrio, M., Tornero, P., and Baeza, M. L. Asthma induced by canary food mix. Allergy Asthma Proc. 2003;24(4):265-268.
    4. 18065. Martín-Muñoz MF, Bartolome B, Caminoa M, et al. Bee pollen: a dangerous food for allergic children. Identification of responsible allergens. Allergol Immunopathol (Madr) 2010;38:263-5. PubMed
    5. 46951. Syhaieva, I. A. [Efficiency of specific immunotherapy in treatment of patients with seasonal allergic rhinitis]. Lik.Sprava. 2006;(1-2):51-53.
    6. 46964. Fernandez-Gonzalez, D., Gonzalez-Parrado, Z., Vega-Maray, A. M., Valencia-Barrera, R. M., Camazon-Izquierdo, B., De, Nuntiis P., and Mandrioli, P. Platanus pollen allergen, Pla a 1: quantification in the atmosphere and influence on a sensitizing populati
  • A severe skin reaction Worth acting on Additional detail

    “Topically, dandelion can cause contact dermatitis and erythema multiforme in sensitive individuals. Dandelion can cause an allergic reaction in individuals sensitive to the Asteraceae/Compositae family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many other herbs.”

    Dandelion · Natural Medicines adverse-effect record, reported in dermatitis.

    5 sources cited
    1. 13478. Jovanovic M, Mimica-Dukic N, Poljacki M, Boza P. Erythema multiforme due to contact with weeds: a recurrence after patch testing. Contact Dermatitis 2003;48:17-25. PubMed
    2. 13481. Lovell CR, Rowan M. Dandelion dermatitis. Contact Dermatitis 1991;25:185-8. PubMed
    3. 42893. Wakelin, S. H., Marren, P., Young, E., and Shaw, S. Compositae sensitivity and chronic hand dermatitis in a seven-year-old boy. Br J Dermatol 1997;137(2):289-291. PubMed
    4. 46945. Ingber, A. Seasonal allergic contact dermatitis from Taraxacum officinale (dandelion) in an Israeli florist. Contact Dermatitis 2000;43(1):49.
    5. 46977. Davies, M. G. and Kersey, P. J. Contact allergy to yarrow and dandelion. Contact Dermatitis 1986;14(4):256-257. PubMed
  • Kidney problems Worth acting on Additional detail

    “In one report, a 56-year-old man with renal impairment developed hyperoxalaemia and peripheral gangrene after ingesting large amounts of dandelion tea (10 to 15 cups daily for 6 months). The adverse effect was attributed to the high oxalate content of dandelion tea (258 mcmol/L) and reduced renal oxalate clearance caused by renal impairment.”

    Dandelion · Natural Medicines adverse-effect record, reported in diabetes.

    2 sources cited
    1. 90639. Moriarty B, Pinney JH, Owen-Casey MP, Rustin MH, Deroide F, Laing C, Davenport A. Digital necrosis from dandelion tea. Br J Dermatol. 2013 Jul;169(1):227-30. PubMed
    2. 46960. Goksu, E., Eken, C., Karadeniz, O., and Kucukyilmaz, O. First report of hypoglycemia secondary to dandelion (Taraxacum officinale) ingestion. Am J Emerg.Med 2010;28(1):111-112. PubMed
  • A severe allergic reaction Worth acting on Additional detail

    “Orally, dandelion seems to be well tolerated.

    Most Common Adverse Effects:

    Orally: Diarrhea, heartburn, and stomach discomfort.

    Topically: Dermatitis in sensitive individuals.

    Serious Adverse Effects (Rare):

    Orally: Anaphylaxis in sensitive individuals.”

    Dandelion · Natural Medicines adverse-effect record, reported in dermatitis.

  • An allergic reaction Worth acting on Additional detail

    Recorded for Dandelion in the same Natural Medicines adverse-effect record shown under Wheezing above.

  • Heartburn Additional detail

    Recorded for Dandelion in the same Natural Medicines adverse-effect record shown under A severe allergic reaction above.

  • Weight loss Additional detail

    Recorded for Dandelion in the same Natural Medicines adverse-effect record shown under Fainting / An irregular heartbeat above.

Showing the 10 most notable of 15 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Dandelion — expand a row for the licensed statement it rests on. We haven’t matched Diphenhydramine, Zinc Oxide to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Diphenhydramine, Zinc Oxide.

From our Q&A

Questions About Dandelion or Diphenhydramine, Zinc Oxide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Dandelion or Diphenhydramine, Zinc Oxide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Diphenhydramine, Zinc Oxide

This page covers Dandelion only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diphenhydramine, Zinc Oxide page lists 6 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Fever Bark (moderate), Iboga (moderate), Turpentine Oil (moderate) and Yohimbe (moderate).

By severity: 5 moderate · 1 minor.

From our pharmacist’s overview on the Diphenhydramine, Zinc Oxide page

“Caladryl Clear, the diphenhydramine and zinc oxide lotion people dab on itchy bites and rashes, carries a short and manageable interaction list. None of its six flagged ingredients rates major; five are moderate and one minor.”

Reviewed by 2 · Jul 18, 2026

Open the Diphenhydramine, Zinc Oxide interaction page

One more smart check

Taking Dandelion as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4,328 real supplement products containing Dandelion, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Dandelion. Even though Dandelion itself has no known interaction with Diphenhydramine, Zinc Oxide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Dandelion and Diphenhydramine, Zinc Oxide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Dandelion
Top 5%

#55 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Diphenhydramine, Zinc Oxide
Steady interest

#2,066 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Dandelion reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Dandelion and Diphenhydramine, Zinc Oxide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Dandelion

What is Dandelion?

Dandelion
  • Water retention (diuretic)
  • Digestive upset
  • Liver and gallbladder support
  • Mild appetite stimulant
  • Skin conditions

Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for these uses is very limited, so its benefits are not well proven. It is generally considered safe as a food, but talk to your pharmacist or doctor before using concentrated supplements, especially if you have allergies or take other medicines.

Taraxacum officinale · Asteraceae · Leaves, roots, and flowers · Tea, capsules, tinctures, liquid extracts, dried root, fresh greens (food)

An interaction check asks whether these two react with each other — it does not ask whether Dandelion is a good idea for someone in your situation. Here is what our Dandelion record says about it on its own.

Dandelion: dosing

There is no official standardized dose for dandelion, and the amount of active compounds can vary a lot between products (leaf, root, tea, tincture, or capsule).Because of this, the best advice is to follow the directions on the product label and not exceed the recommended amount.

From our Dandelion monograph — the full record covers uses, side effects and every documented interaction.

Read the full Dandelion monograph & all interactions
Keep checking

Other Drugs & Dandelion

Browse every other medication we’ve checked against Dandelion — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
457Moderate
0Minor
2,372No known interaction
457 Moderate 2,372 No interaction
Moderate

457 interactions

Showing 60 of 457 moderate interactions — see all 457 on the Dandelion page.

No interaction 2,372 drugs checked — show the list

We also checked Dandelion against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,372 medications checked with no known interaction — see the full Dandelion list.

See the full Dandelion interactions page
See every supplement checked against Diphenhydramine, Zinc Oxide, ranked by severity
Evidence & sources

Dandelion References

The 27 references that drive our Dandelion monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol 2001;53:1323-9. PubMed
  2. Williams CA, Goldstone F, Greenham J. Flavonoids, cinnamic acids and coumarins from the different tissues and medicinal preparations of Taraxacum officinale. Phytochemistry 1996;42:121-7. PubMed
  3. Hussain Z, Waheed A, Qureshi RA, et al. The effect of medicinal plants of Islamabad and Murree region of Pakistan on insulin secretion from INS-1 cells. Phytother Res 2004;18:73-7. PubMed
  4. Racz-Kotilla E, Racz G, Solomon A. The action of Taraxacum officinale extracts on the body weight and diuresis of laboratory animals. Planta Med 1974;26:212-7. PubMed
  5. Zhu M, Wong PY, Li RC. Effects of taraxacum mongolicum on the bioavailability and disposition of ciprofloxacin in rats. J Pharm Sci 1999;88:632-4. PubMed
  6. Jovanovic M, Mimica-Dukic N, Poljacki M, Boza P. Erythema multiforme due to contact with weeds: a recurrence after patch testing. Contact Dermatitis 2003;48:17-25. PubMed
  7. Chivato T, Juan F, Montoro A, Laguna R. Anaphylaxis induced by ingestion of a pollen compound. J Investig Allergol Clin Immunol 1996;6:208-9.
  8. Cohen SH, Yunginger JW, Rosenberg N, Fink JN. Acute allergic reaction after composite pollen ingestion. J Allergy Clin Immunol 1979;64:270-4. PubMed
  9. Lovell CR, Rowan M. Dandelion dermatitis. Contact Dermatitis 1991;25:185-8. PubMed
  10. Agarwal SC, Crook JR, Pepper CB. Herbal remedies -- how safe are they? A case report of polymorphic ventricular tachycardia/ventricular fibrillation induced by herbal medication used for obesity. Int J Cardiol 2006;106:260-1. PubMed
  11. Martín-Muñoz MF, Bartolome B, Caminoa M, et al. Bee pollen: a dangerous food for allergic children. Identification of responsible allergens. Allergol Immunopathol (Madr) 2010;38:263-5. PubMed
  12. Neef H, Cilli F, Declerck PJ, et al. Platelet anti-aggregating activity of Taraxacum officinale Weber. Phytotherapy Research 1996;10:s138-s140.
  13. Cuzzolin L, Zaffani S, and Benoni G. Safety implications regarding use of phytomedicines. Eur.J Clin Pharmacol. 2006;62:37-42. PubMed
  14. Posadzki, P., Watson, L. K., and Ernst, E. Adverse effects of herbal medicines: an overview of systematic reviews. Clin Med 2013;13(1):7-12. PubMed
  15. Wakelin, S. H., Marren, P., Young, E., and Shaw, S. Compositae sensitivity and chronic hand dermatitis in a seven-year-old boy. Br J Dermatol 1997;137(2):289-291. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Dandelion and Diphenhydramine, Zinc Oxide Together: Common Questions

Is it safe to take Dandelion with Diphenhydramine, Zinc Oxide?
We do not list a known interaction between Dandelion and Diphenhydramine, Zinc Oxide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Dandelion and Diphenhydramine, Zinc Oxide combination checked?
Interactions in our licensed database are recorded against drug classes. Diphenhydramine, Zinc Oxide is filed under 2 classifications, and Dandelion has documented interactions with 7 drug classes — none of Diphenhydramine, Zinc Oxide's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Dandelion interact with any other medications?
Yes. Dandelion has 457 documented drug interactions in our database — Diphenhydramine, Zinc Oxide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Diphenhydramine, Zinc Oxide interact with any supplements?
Yes. Diphenhydramine, Zinc Oxide has documented interactions with 6 supplements in our database — Dandelion is not one of them. The Diphenhydramine, Zinc Oxide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Dandelion monograph Uses, safety profile, and every drug interaction in one place Diphenhydramine, Zinc Oxide supplement interactions Every supplement checked against Diphenhydramine, Zinc Oxide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 27 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Diphenhydramine, Zinc Oxide and Dandelion?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.