Drug & supplement interaction

Delta-9-tetrahydrocannabinol (thc) + Aprocitentan

Aprocitentan brand name: Tryvio.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Aprocitentan falls into 3 drug categories that Delta-9-tetrahydrocannabinol (thc) can interact with; the most serious is rated moderate. Theoretically, CYP3A4 inhibitors might increase the levels and clinical effects of THC.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions3
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Delta-9-tetrahydrocannabinol (thc) and Aprocitentan

These two interact in 3 distinct ways. Each one is explained separately below.

Why Are There 3 Interactions?

Delta-9-tetrahydrocannabinol (thc) interacts with whole categories of medication. Aprocitentan falls into 3 of those categories, so it can interact with Delta-9-tetrahydrocannabinol (thc) in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

CYTOCHROME P450 3A4 (CYP3A4) INHIBITORS

1 of 3

Why this applies to Aprocitentan

Aprocitentan falls under CYTOCHROME P450 3A4 (CYP3A4) INHIBITORS — the group Delta-9-tetrahydrocannabinol (thc) interacts with.

Theoretically, CYP3A4 inhibitors might increase the levels and clinical effects of THC.
THC is a substrate of CYP3A4 enzymes.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for combining THC with Tryvio (aprocitentan). Aprocitentan can act as a CYP3A4 inhibitor, and THC is broken down partly by that same CYP3A4 pathway. So in theory, aprocitentan could slow how quickly your body clears THC. That means THC might hang around longer and hit a bit harder, so you could notice more of its usual effects like drowsiness, dizziness, a stronger high, slowed reaction time, or feeling foggy.

I want to be honest that this is theoretical, based on how the drugs work rather than real-world reports, so it may not amount to much for many people. Still, since dizziness and lightheadedness are already possible with a blood pressure medicine, please loop in your pharmacist or doctor before mixing the two, and avoid driving until you know how you feel.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Product information for Marinol. AbbVie. North Chicago, IL 60064. August 2017. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/018651s029lbl.pdf.
Moderate

CYTOCHROME P450 2C9 (CYP2C9) INHIBITORS

2 of 3

Aprocitentan also falls under CYTOCHROME P450 2C9 (CYP2C9) INHIBITORS.

Theoretically, drugs that are CYP2C9 inhibitors might increase the levels and adverse effects of THC.
THC is a substrate of CYP2C9 enzymes.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the short version: this interaction is really about what happens to the THC, not the other way around. Aprocitentan (Tryvio), your blood pressure medicine, can act as a CYP2C9 inhibitor, and CYP2C9 is one of the enzymes your body uses to clear THC. So in theory, if you take THC while on aprocitentan, the THC may hang around longer and hit a little harder. That could mean a stronger high, more drowsiness, dizziness, or foggy thinking.

I'll be honest with you though, this is a theoretical concern based on how the drug works on paper, not real-world reports, so I don't want to alarm you. Still, please loop in your pharmacist or doctor before combining them, especially since feeling extra dizzy on a blood pressure medication is worth watching.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Product information for Marinol. AbbVie. North Chicago, IL 60064. August 2017. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/018651s029lbl.pdf.
Moderate

CYTOCHROME P450 3A4 (CYP3A4) INDUCERS

3 of 3

Aprocitentan also falls under CYTOCHROME P450 3A4 (CYP3A4) INDUCERS.

Theoretically, CYP3A4 inducers might reduce the levels and clinical effects of THC.
THC is a substrate of CYP3A4 enzymes.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the situation if you use cannabis or THC products while taking Tryvio (aprocitentan), your blood pressure medicine. Aprocitentan can act as a mild CYP3A4 inducer, which basically means it can rev up one of the liver enzymes that breaks down THC. In theory, that could clear THC out of your system a bit faster and make its effects (the high, the relaxation, appetite changes) feel weaker or shorter than usual.

I want to be honest with you: this is a theoretical concern based on how these two work on paper, not something proven in real patients. It won't hurt your blood pressure control. Still, it's worth mentioning to your pharmacist or doctor so they know everything you're taking.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Product information for Marinol. AbbVie. North Chicago, IL 60064. August 2017. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/018651s029lbl.pdf.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Delta-9-tetrahydrocannabinol (thc) Also Interacts With Other Medications

Delta-9-tetrahydrocannabinol (thc) has 762 moderate, 336 minor known drug interactions in our database — the Aprocitentan one above is among them. If you take anything else, check it against the full list below.

Moderate 762 Minor 336 No known interaction 1,732 (incl. Aprocitentan)
Taking anything else?

Check Another of Your Medications Against Delta-9-tetrahydrocannabinol (thc)

Covers the 2,830 medications we’ve checked against Delta-9-tetrahydrocannabinol (thc). Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Aprocitentan

This page covers Delta-9-tetrahydrocannabinol (thc) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aprocitentan page lists 189 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Beer (major) and Siberian Cocklebur (major).

By severity: 7 major · 161 moderate · 21 minor.

From our pharmacist’s overview on the Aprocitentan page

“Aprocitentan (Tryvio) is prescribed when blood pressure stays high despite other medicines, so anything that pushes your pressure around cuts straight to why you take it. Most of the 189 ingredients here do exactly that: some add to the drop and can leave you dizzy or faint, while others, tyramine among them, push pressure back up and…”

Reviewed by 2 · Jul 18, 2026

Open the Aprocitentan interaction page

How much people look this up

Where Delta-9-tetrahydrocannabinol (thc) and Aprocitentan Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Delta-9-tetrahydrocannabinol (thc)
Top half

#557 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aprocitentan
Top 25%

#377 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Delta-9-tetrahydrocannabinol (thc)

What is Delta-9-tetrahydrocannabinol (thc)?

Delta-9-tetrahydrocannabinol (thc)
  • Chronic or nerve pain
  • Nausea and vomiting from chemotherapy
  • Appetite loss and weight loss
  • Muscle spasticity
  • Sleep problems
  • Anxiety and stress

THC is the main mind-altering compound in cannabis and is best known for causing a 'high.' A prescription form (dronabinol) is approved for chemotherapy-related nausea and appetite loss, but for most other uses the evidence is mixed or limited, and THC can impair thinking and driving. It should be avoided in pregnancy and breastfeeding and used only with medical guidance.

Read the full Delta-9-tetrahydrocannabinol (thc) monograph & all interactions
Medication

About Aprocitentan

What Is Aprocitentan Used For?

Brand name: Tryvio

Tryvio is used to treat high blood pressure (hypertension) in adults who are already taking other blood pressure medications but still don't have their blood pressure under control. It is always used in combination with other antihypertensive (blood pressure-lowering) drugs — not on its own.

Lowering blood pressure reduces the risk of serious cardiovascular events, including strokes and heart attacks. Tryvio has not been shown in controlled trials to directly reduce those events itself, but blood pressure control overall does.

See full Aprocitentan drug information
Keep checking

Other Drugs & Delta-9-tetrahydrocannabinol (thc)

Browse every other medication we’ve checked against Delta-9-tetrahydrocannabinol (thc) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
762Moderate
336Minor
1,731No known interaction
762 Moderate 336 Minor 1,731 No interaction
Moderate

762 interactions

Showing 60 of 762 moderate interactions — see all 762 on the Delta-9-tetrahydrocannabinol (thc) page.

Minor

336 interactions

Showing 60 of 336 minor interactions — see all 336 on the Delta-9-tetrahydrocannabinol (thc) page.

No interaction 1,731 drugs checked — show the list

We also checked Delta-9-tetrahydrocannabinol (thc) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,731 medications checked with no known interaction — see the full Delta-9-tetrahydrocannabinol (thc) list.

See the full Delta-9-tetrahydrocannabinol (thc) interactions page
See every supplement checked against Aprocitentan, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Delta-9-tetrahydrocannabinol (thc) monograph › Uses, safety, and every drug interaction in one place Aprocitentan supplement interactions › Every supplement checked against Aprocitentan, ranked by severity Aprocitentan drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Delta-9-tetrahydrocannabinol (thc) and Aprocitentan Together: Common Questions

Can you take Delta-9-tetrahydrocannabinol (thc) with Aprocitentan?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 3 interactions listed for Delta-9-tetrahydrocannabinol (thc) and Aprocitentan?
Aprocitentan belongs to more than one drug category, and Delta-9-tetrahydrocannabinol (thc) interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Delta-9-tetrahydrocannabinol (thc) and Aprocitentan interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.