Drug & supplement interaction

Dimethylhexylamine (dmha) + Sodium Oxybate

Sodium Oxybate brand name: Xyrem.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Dimethylhexylamine (dmha) and Sodium Oxybate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Sodium Oxybate states a food rule worth keeping to.

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Interaction report

Dimethylhexylamine (dmha) and Sodium Oxybate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sodium Oxybate and Dimethylhexylamine (dmha) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Dimethylhexylamine (dmha) safety at a glance

Dimethylhexylamine... overall Avoid DMHA is an unapproved stimulant with serious safety concerns and is best avoided.
Pregnancy Avoid Avoid during pregnancy; no safety data and it is a potent stimulant.
Breastfeeding Avoid Avoid while breastfeeding; no safety data and it may pass into breast milk.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sodium Oxybate and Dimethylhexylamine (dmha)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sodium Oxybate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sodium Oxybate is filed under 3 classifications — sodium-containing drugs, seizure threshold lowering drugs, oral drugs. Dimethylhexylamine (dmha) has documented interactions with 1 drug class — the most serious being stimulant drugs (moderate) — and none of Sodium Oxybate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Dimethylhexylamine (dmha) Does Interact With Other Medications

Dimethylhexylamine (dmha) has 172 moderate known drug interactions in our database — Sodium Oxybate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 172 No known interaction 2,658 (incl. Sodium Oxybate)
Taking anything else?

Check Another of Your Medications Against Dimethylhexylamine (dmha)

Covers the 2,830 medications we’ve checked against Dimethylhexylamine (dmha). Pick one to open its full report.

What to actually watch for

What Dimethylhexylamine (dmha) Itself Has Been Linked To

This is not an interaction — nothing below involves Sodium Oxybate. It is the side-effect record for Dimethylhexylamine (dmha) on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Dimethylhexylamine (dmha), this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Raised blood pressure Worth acting on Additional detail

    “Theoretically, DMHA might be associated with an increased risk for hypertension, tachycardia, and cardiovascular events, as have been reported with a structurally similar stimulant, dimethylamylamine (DMAA).”

    Dimethylhexylamine (dmha) · Natural Medicines adverse-effect record, reported in hypertension.

    3 sources cited
    1. 17906. McCarthy C, Farney TM, Canale RE, et al. A finished dietary supplement stimulates lipolysis and metabolic rate in young men and women. Nutr Metab Insights 2012;5:23-31. PubMed
    2. 17907. McCarthy C, Canale RE, Alleman RJ, et al. Biochemical and anthropometric effects of a weight loss dietary supplement in health men and women. Nutr Metab Insights 2012;5:13-22.
    3. 17908. Farney TM, McCarthy C, Canale RE, et al. Hemodynamic and hematologic profile of health adults ingesting dietary supplements containing 1,3-dimethylamylamine and caffeine. Nutr Metab Insights 2012;5:1-12.
  • A fast or pounding heartbeat Additional detail

    Recorded for Dimethylhexylamine (dmha) in the same Natural Medicines adverse-effect record shown under Raised blood pressure above.

Everything above comes from the Natural Medicines adverse-effect record for Dimethylhexylamine (dmha) — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Sodium Oxybate’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Sodium Oxybate column appears here.

How to take them

Some Sodium Oxybate Products Have a Food Rule — Dimethylhexylamine (dmha) Should Not Break It

At least one FDA label for a product containing Sodium Oxybate says to take it with food. If you take Dimethylhexylamine (dmha) on an empty stomach out of habit, keep them separate — and take Sodium Oxybate with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Sodium Oxybate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

• Allow 2 hours after eating before dosing ( 2.3 ).

From the Dosage and Administration section of the FDA label we read for Sodium Oxybate — where that label names a specific product, the instruction is that product's. See the Sodium Oxybate drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Dimethylhexylamine (dmha) or Sodium Oxybate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Dimethylhexylamine (dmha) or Sodium Oxybate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Sodium Oxybate

This page covers Dimethylhexylamine (dmha) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sodium Oxybate page lists 25 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Biofeedback (moderate), Coffee Charcoal (moderate), Dendrobium (moderate) and European Mandrake (moderate).

By severity: 1 major · 15 moderate · 9 minor.

From our pharmacist’s overview on the Sodium Oxybate page

“Activated charcoal is the single major-rated interaction with sodium oxybate (Xyrem), and it earns that rating because the drug only works if each dose is fully absorbed; charcoal can bind it in the gut and weaken the nighttime control it provides for narcolepsy. Treat this list with genuine care, since 17 of the 25 ingredients on file…”

Reviewed by 2 · Jul 18, 2026

Open the Sodium Oxybate interaction page

One more smart check

Taking Dimethylhexylamine (dmha) as Part of a Dietary Supplement Product? Check It for Interactions

We hold 72 real supplement products containing Dimethylhexylamine (dmha), each one broken down to its full ingredient list — and combination products often carry several ingredients besides Dimethylhexylamine (dmha). Even though Dimethylhexylamine (dmha) itself has no known interaction with Sodium Oxybate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Dimethylhexylamine (dmha) and Sodium Oxybate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Dimethylhexylamine (dmha)
Steady interest

#1,019 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sodium Oxybate
Top half

#1,291 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Dimethylhexylamine (dmha) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Dimethylhexylamine (dmha) and Sodium Oxybate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Dimethylhexylamine (dmha)

What is Dimethylhexylamine (dmha)?

  • Pre-workout energy
  • Fat loss and weight management
  • Athletic performance
  • Appetite suppression
  • Focus and stimulation

DMHA (dimethylhexylamine, also called octodrine) is a synthetic stimulant added to some pre-workout and weight-loss supplements, often falsely labeled as a natural plant extract. It has not been shown to be safe as a dietary supplement, has been flagged by the FDA as an unapproved and potentially dangerous ingredient, and is best avoided. Talk to a pharmacist or doctor before using any product that contains it.

Synthetic chemical compound (not from a plant) · Capsules, tablets, powders, pre-workout blends

An interaction check asks whether these two react with each other — it does not ask whether Dimethylhexylamine (dmha) is a good idea for someone in your situation. Here is what our Dimethylhexylamine (dmha) record says about it on its own.

Dimethylhexylamine (dmha): dosing

There is no established safe or standardized dose for DMHA, and we do not recommend taking it. Do not try to guess a dose or combine it with other stimulants such as caffeine.

From our Dimethylhexylamine (dmha) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Dimethylhexylamine (dmha) monograph & all interactions
Medication

About Sodium Oxybate

What Is Sodium Oxybate Used For?

Brand name: Xyrem

Sodium oxybate treats two major symptoms of narcolepsy: cataplexy (sudden muscle weakness triggered by emotion) and excessive daytime sleepiness (EDS). It is available in several products, each approved for these uses.

Xyrem (oral solution) and the generic sodium oxybate oral solution are approved for cataplexy or EDS in patients with narcolepsy. Lumryz (extended-release oral suspension) is specifically approved for cataplexy or EDS in patients 7 years of age and older with narcolepsy. The generic sodium oxybate oral solution label does not include the pediatric indication due to marketing exclusivity held by Xyrem.

Most-Reported Side Effects for Sodium Oxybate

From FAERS, the FDA’s public side-effect reporting system (65,536 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 4,928 reports
Anxiety 3,979 reports
Somnolence 3,965 reports
Insomnia 3,371 reports
Feeling abnormal 3,223 reports
See full Sodium Oxybate drug information
Keep checking

Other Drugs & Dimethylhexylamine (dmha)

Browse every other medication we’ve checked against Dimethylhexylamine (dmha) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
172Moderate
0Minor
2,657No known interaction
172 Moderate 2,657 No interaction
Moderate

172 interactions

Showing 60 of 172 moderate interactions — see all 172 on the Dimethylhexylamine (dmha) page.

No interaction 2,657 drugs checked — show the list

We also checked Dimethylhexylamine (dmha) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,657 medications checked with no known interaction — see the full Dimethylhexylamine (dmha) list.

See the full Dimethylhexylamine (dmha) interactions page
See every supplement checked against Sodium Oxybate, ranked by severity
Evidence & sources

Dimethylhexylamine (dmha) References

The 6 references that drive our Dimethylhexylamine (dmha) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McCarthy C, Farney TM, Canale RE, et al. A finished dietary supplement stimulates lipolysis and metabolic rate in young men and women. Nutr Metab Insights 2012;5:23-31. PubMed
  2. McCarthy C, Canale RE, Alleman RJ, et al. Biochemical and anthropometric effects of a weight loss dietary supplement in health men and women. Nutr Metab Insights 2012;5:13-22.
  3. Farney TM, McCarthy C, Canale RE, et al. Hemodynamic and hematologic profile of health adults ingesting dietary supplements containing 1,3-dimethylamylamine and caffeine. Nutr Metab Insights 2012;5:1-12.
  4. Rasmussen N, Keizers PH. History full circle: 'novel' sympathomimetics in supplements. Drug Test Anal 2016;8(3-4):283-6. PubMed
  5. Monroe RR, Drell HJ. Oral use of stimulants obtained from inhalers. J Am Med Assoc 1947; 135(14):909-15. PubMed
  6. Fellows EJ. The pharmacology of 2-amino-6-methylheptane. J Pharmacol Exp Ther 1947;90(4):351-8. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Dimethylhexylamine (dmha) and Sodium Oxybate Together: Common Questions

Is it safe to take Dimethylhexylamine (dmha) with Sodium Oxybate?
We do not list a known interaction between Dimethylhexylamine (dmha) and Sodium Oxybate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Dimethylhexylamine (dmha) and Sodium Oxybate at the same time of day?
At least one FDA label for a product containing Sodium Oxybate says to take it with food. If you take Dimethylhexylamine (dmha) on an empty stomach out of habit, keep them separate and take Sodium Oxybate with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Sodium Oxybate products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Dimethylhexylamine (dmha) and Sodium Oxybate combination checked?
Interactions in our licensed database are recorded against drug classes. Sodium Oxybate is filed under 3 classifications, and Dimethylhexylamine (dmha) has documented interactions with 1 drug class — none of Sodium Oxybate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Dimethylhexylamine (dmha) interact with any other medications?
Yes. Dimethylhexylamine (dmha) has 172 documented drug interactions in our database — Sodium Oxybate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sodium Oxybate interact with any supplements?
Yes. Sodium Oxybate has documented interactions with 25 supplements in our database — Dimethylhexylamine (dmha) is not one of them. The Sodium Oxybate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Dimethylhexylamine (dmha) monograph Uses, safety profile, and every drug interaction in one place Sodium Oxybate drug information The full plain-English guide to this medication Sodium Oxybate supplement interactions Every supplement checked against Sodium Oxybate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sodium Oxybate and Dimethylhexylamine (dmha)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.