Drug & supplement interaction

Divi-divi + Tasimelteon

Tasimelteon brand names: Hetlioz, Hetlioz Lq.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Divi-divi and Tasimelteon in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Tasimelteon states a food rule worth keeping to.

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Interaction report

Divi-divi and Tasimelteon

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tasimelteon and Divi-divi in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Divi-divi at all — not against Tasimelteon, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Divi-divi safety at a glance

Divi-divi overall Not established There is little reliable human safety data for medicinal use of divi-divi.
Pregnancy Avoid Safety has not been established, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety data exists for nursing, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tasimelteon and Divi-divi? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Tasimelteon’s Own FDA Label Lists

This is not an interaction — none of it involves Divi-divi. These are the most notable effects listed in the ADVERSE REACTIONS section of Tasimelteon’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 2 of them are worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on
  • A higher chance of infection Worth acting on
  • Vivid dreams or nightmares mentioned in 8.5% of FDA reports for Tasimelteon
  • Trouble sleeping mentioned in 19.8% of FDA reports for Tasimelteon
  • Headache mentioned in 6.7% of FDA reports for Tasimelteon

From the ADVERSE REACTIONS section of the FDA label for Tasimelteon. Read the label on DailyMed › Where a percentage is shown, it is the share of 5,765 voluntary FDA FAERS reports for Tasimelteon that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Divi-divi’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Divi-divi side to compare — that is a limit of the record, not a statement that Divi-divi has no side effects.

How to take them

Some Tasimelteon Products Have a Food Rule — Divi-divi Should Not Break It

At least one FDA label for a product containing Tasimelteon says to take it on an empty stomach. Most supplements — Divi-divi included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Tasimelteon on its own and move Divi-divi to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Tasimelteon products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Indicated Population Dosage Form Body Weight Recommended Dosage Non-24 ( 2.2 ) Adults Capsules Not applicable 20 mg one hour prior to bedtime Nighttime sleep disturbances in SMS ( 2.3 ) Patients 16 years of age and older Capsules Not applicable 20 mg one hour prior to bedtime Pediatric Patients 3 to 15 years of age Oral Suspension ≤ 28 kg 0.7 mg/kg one hour before bedti

From the Dosage and Administration section of the FDA label we read for Tasimelteon — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Tasimelteon

This page covers Divi-divi only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tasimelteon page lists 218 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 166 moderate · 43 minor.

From our pharmacist’s overview on the Tasimelteon page

“Tasimelteon (Hetlioz) resets the body clock in people with non-24-hour sleep-wake disorder, and the sleep aids they often reach for, melatonin and kava among them, sit on an interaction list that deserves real respect. Nine of the 218 ingredients on file rate major, mostly in two directions: sedatives like kava stack drowsiness onto a…”

Reviewed by 2 · Jul 18, 2026

Open the Tasimelteon interaction page

One more smart check

Taking Divi-divi as Part of a Dietary Supplement Product? Check It for Interactions

We hold 20 real supplement products containing Divi-divi, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Divi-divi. Even though Divi-divi itself has no known interaction with Tasimelteon, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Divi-divi and Tasimelteon Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Divi-divi
Steady interest

#934 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tasimelteon
Top half

#1,350 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Divi-divi is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Divi-divi reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Divi-divi and Tasimelteon records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Divi-divi

What is Divi-divi?

  • Source of tannins for tanning leather
  • Traditional astringent for skin
  • Mouth and throat irritation (traditional gargles)
  • Wound and sore care (folk use)
  • Mild digestive complaints (folk use)

Divi-divi is a tropical tree whose tannin-rich seed pods have long been used in leather tanning and in traditional folk remedies, mostly as an astringent. There is very little modern human research to support any health benefit, so it should not be relied on to treat any medical condition. If you are considering it, talk with a pharmacist or doctor first.

Caesalpinia coriaria · Fabaceae · Seed pods (and sometimes bark) · Powdered pod extract, decoctions, and traditional topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Divi-divi is a good idea for someone in your situation. Here is what our Divi-divi record says about it on its own.

Divi-divi: dosing

There is no established or standardized medicinal dose for divi-divi. Traditional preparations vary widely and are not measured in a consistent way.If you choose to use a product that contains divi-divi, follow the directions on the label and do not exceed the suggested amount.

From our Divi-divi monograph — the full record covers uses, side effects and every documented interaction.

Read the full Divi-divi monograph & all interactions
Medication

About Tasimelteon

What Is Tasimelteon Used For?

Brand names: Hetlioz, Hetlioz Lq

Tasimelteon capsules are approved to treat Non-24-Hour Sleep-Wake Disorder (Non-24) in adults. Non-24 is a condition where the body's internal clock does not align with the normal 24-hour day, causing sleep and wake times to shift continuously.

Hetlioz capsules are also approved to treat nighttime sleep disturbances in Smith-Magenis Syndrome (SMS) in patients 16 years of age and older. Hetlioz LQ oral suspension is approved specifically for nighttime sleep disturbances in SMS in pediatric patients ages 3 to 15 years.

Most-Reported Side Effects for Tasimelteon

From FAERS, the FDA’s public side-effect reporting system (5,770 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Insomnia 728 reports
Middle insomnia 414 reports
Somnolence 408 reports
Headache 386 reports
Nightmare 268 reports
See full Tasimelteon drug information
Keep checking

Other Drugs & Divi-divi

Browse every other medication we’ve checked against Divi-divi — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Divi-divi against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Divi-divi list.

See the full Divi-divi interactions page
See every supplement checked against Tasimelteon, ranked by severity
Evidence & sources

Divi-divi References

The 1 sources that drive our Divi-divi monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Divi-divi is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Tannins — MedlinePlus / NIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Divi-divi and Tasimelteon Together: Common Questions

Is it safe to take Divi-divi with Tasimelteon?
We do not list a known interaction between Divi-divi and Tasimelteon. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Divi-divi and Tasimelteon at the same time of day?
At least one FDA label for a product containing Tasimelteon says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Tasimelteon on its own and move Divi-divi to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Does Tasimelteon interact with any supplements?
Yes. Tasimelteon has documented interactions with 218 supplements in our database — Divi-divi is not one of them. The Tasimelteon interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Divi-divi monograph Uses, safety profile, and every drug interaction in one place Tasimelteon drug information The full plain-English guide to this medication Tasimelteon supplement interactions Every supplement checked against Tasimelteon, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tasimelteon and Divi-divi?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.