Drug & supplement interaction

Dwarf Pine Needle + Crizotinib

Crizotinib brand name: Xalkori.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Dwarf Pine Needle and Crizotinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Dwarf Pine Needle and Crizotinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Crizotinib and Dwarf Pine Needle in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Dwarf Pine Needle at all — not against Crizotinib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Dwarf Pine Needle safety at a glance

Dwarf Pine Needle overall Use caution Generally used externally or as an inhalant; the essential oil is toxic if swallowed and can irritate skin.
Pregnancy Avoid Not enough safety information; avoid the essential oil during pregnancy unless your doctor approves.
Breastfeeding Avoid Safety while breastfeeding is not established, so it is best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Crizotinib and Dwarf Pine Needle? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Dwarf Pine Needle Itself Has Been Linked To

This is not an interaction — nothing below involves Crizotinib. It is the side-effect record for Dwarf Pine Needle on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Dwarf Pine Needle, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • An allergic reaction Worth acting on Additional detail

    “Topically, dwarf pine needle oil can cause skin irritation and allergic reactions (11).”

    Dwarf Pine Needle · Natural Medicines adverse-effect record, reported in skin irritation.

    1 source cited
    1. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

    “Dwarf pine needle oil can cause skin irritation and allergic reactions (11).”

    Dwarf Pine Needle · Natural Medicines adverse-effect record, reported in skin irritation.

    1 source cited
    1. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

Everything above comes from the Natural Medicines adverse-effect record for Dwarf Pine Needle — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Crizotinib’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Crizotinib column appears here.

Everything else you take

See Every Supplement That Interacts With Crizotinib

This page covers Dwarf Pine Needle only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Crizotinib page lists 157 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 8 major · 112 moderate · 37 minor.

From our pharmacist’s overview on the Crizotinib page

“Grapefruit tops my worry list for crizotinib (Xalkori), a targeted pill for ALK-positive lung cancer. It blocks the enzyme (CYP3A4) that clears crizotinib, letting levels climb and side effects with them, and it is one of eight major-rated entries among the 157 supplements and herbs on file for this drug.”

Reviewed by 2 · Jul 18, 2026

Open the Crizotinib interaction page

How much people look this up

Where Dwarf Pine Needle and Crizotinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Dwarf Pine Needle
Steady interest

#1,065 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Crizotinib
Steady interest

#2,340 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Dwarf Pine Needle reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Dwarf Pine Needle and Crizotinib records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Dwarf Pine Needle

What is Dwarf Pine Needle?

  • Coughs and congestion
  • Muscle and joint aches (topical)
  • Inhalation for stuffy nose
  • Aromatherapy and relaxation
  • Mild antimicrobial use

Dwarf pine needle is the leaf and essential oil of the mountain pine (Pinus mugo), used mainly in inhalants, chest rubs, and bath products for coughs, congestion, and sore muscles. Solid human evidence is limited, and the essential oil should never be swallowed. Use it diluted and externally only, and check with a pharmacist or doctor first—especially if you are pregnant, breastfeeding, or have asthma.

Pinus mugo · Pinaceae · Needles (leaves) and essential oil distilled from them · Essential oil, inhalants and chest rubs, bath products, steam inhalations

An interaction check asks whether these two react with each other — it does not ask whether Dwarf Pine Needle is a good idea for someone in your situation. Here is what our Dwarf Pine Needle record says about it on its own.

Dwarf Pine Needle: dosing

There is no established standardized dose for dwarf pine needle. It is usually used in small amounts within finished products like chest rubs, inhalants, and bath preparations.Follow the directions on the product label exactly. If you use the pure essential oil, dilute it well in a carrier oil before applying it to the skin, and never take it by mouth.

From our Dwarf Pine Needle monograph — the full record covers uses, side effects and every documented interaction.

Read the full Dwarf Pine Needle monograph & all interactions
Medication

About Crizotinib

What Is Crizotinib Used For?

Brand name: Xalkori

Xalkori (crizotinib) is used to treat adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors test positive for the ALK or ROS1 gene abnormality, as confirmed by an FDA-approved test.

Xalkori is also used to treat pediatric patients aged 1 year and older and young adults with relapsed or refractory systemic ALK-positive anaplastic large cell lymphoma (ALCL). Additionally, it treats adult and pediatric patients aged 1 year and older with unresectable, recurrent, or refractory ALK-positive inflammatory myofibroblastic tumor (IMT). Note: Xalkori's safety and effectiveness in older adults with relapsed or refractory ALK-positive ALCL have not been established.

Most-Reported Side Effects for Crizotinib

From FAERS, the FDA’s public side-effect reporting system (12,638 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Disease progression 1,216 reports
Nausea 1,118 reports
Neoplasm progression 1,112 reports
Diarrhea 846 reports
Vomiting 795 reports
See full Crizotinib drug information
Keep checking

Other Drugs & Dwarf Pine Needle

Browse every other medication we’ve checked against Dwarf Pine Needle — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Dwarf Pine Needle References

The 1 references that drive our Dwarf Pine Needle monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Dwarf Pine Needle and Crizotinib Together: Common Questions

Is it safe to take Dwarf Pine Needle with Crizotinib?
We do not list a known interaction between Dwarf Pine Needle and Crizotinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Crizotinib interact with any supplements?
Yes. Crizotinib has documented interactions with 157 supplements in our database — Dwarf Pine Needle is not one of them. The Crizotinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Crizotinib and Dwarf Pine Needle?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.