Drug & supplement interaction

Dymethazine + Pimecrolimus

Pimecrolimus brand name: Elidel.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Dymethazine and Pimecrolimus in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Dymethazine and Pimecrolimus

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pimecrolimus and Dymethazine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Dymethazine at all — not against Pimecrolimus, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Dymethazine safety at a glance

Dymethazine overall Avoid Dymethazine is a designer anabolic steroid with serious liver and hormonal risks and is best avoided entirely.
Pregnancy Possibly Unsafe When used orally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss,... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss,... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pimecrolimus and Dymethazine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Dymethazine Itself Has Been Linked To

This is not an interaction — nothing below involves Pimecrolimus. It is the side-effect record for Dymethazine on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Dymethazine, this list is the first place to look. 3 entries are worth acting on rather than waiting out — marked below.

  • Yellowing of the skin or eyes Worth acting on Additional detail

    “There is a case of cholestatic jaundice with elevated liver enzymes, dark urine, clay stools, and pruritus in a 26-year-old male, likely related to the use of a product (Super DMZ Rx 2.0) containing methylstenbolone 10 mg and dymethazine 10 mg per capsule. The product was used at manufacturer-recommended doses of two capsules daily for up to one month. Liver enzyme levels gradually decreased after discontinuation.”

    Dymethazine · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 108298. Agbenyefia P, Arnold CA, Kirkpatrick R 3rd. Cholestatic jaundice with the use of methylstenbolone and dymethazine, designer steroids found in super DMZ Rx 2.0 "Nutritional Supplement": A case report. J Investig Med High Impact Case Rep 2014;2(2):232470961 PubMed
  • Kidney problems Worth acting on Additional detail

    “Orally, dymethazine is possibly unsafe. As an anabolic androgenic steroid, there is concern that it might cause serious side effects including stroke, kidney failure, and liver injury.”

    Dymethazine · Natural Medicines adverse-effect record, reported in kidney failure.

  • Liver problems Worth acting on Additional detail

    Recorded for Dymethazine in the same Natural Medicines adverse-effect record shown under Kidney problems above.

  • Itching Additional detail

    Recorded for Dymethazine in the same Natural Medicines adverse-effect record shown under Yellowing of the skin or eyes above.

Everything above comes from the Natural Medicines adverse-effect record for Dymethazine — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Pimecrolimus’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Pimecrolimus column appears here.

Special populations

Dymethazine in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss, acne, and behavioral changes. Anabolic androgenic steroid use has also been associated with hepatotoxicity and increased risk for heart disease. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing anabolic steroids are dangerous. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Pimecrolimus

This page covers Dymethazine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pimecrolimus page lists 3 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).

By severity: 2 moderate · 1 minor.

From our pharmacist’s overview on the Pimecrolimus page

“Pimecrolimus (Elidel) is an eczema cream, applied to the skin rather than swallowed, so its supplement interactions are few and they follow one pattern. All three ingredients on file are also used topically, and the two rated moderate, DMSO and turpentine oil, may pull more of the drug through the skin, amplifying both its benefit and…”

Reviewed by 2 · Jul 18, 2026

Open the Pimecrolimus interaction page

One more smart check

Taking Dymethazine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 18 real supplement products containing Dymethazine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Dymethazine. Even though Dymethazine itself has no known interaction with Pimecrolimus, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Dymethazine and Pimecrolimus Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Dymethazine
Steady interest

#981 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pimecrolimus
Steady interest

#1,669 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Dymethazine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Dymethazine and Pimecrolimus records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Dymethazine

What is Dymethazine?

  • Muscle building
  • Strength gains
  • Bodybuilding bulking cycles
  • Performance enhancement

Dymethazine is a synthetic anabolic-androgenic steroid (a so-called 'prohormone' or 'designer steroid'), not a true dietary supplement or herb. It carries serious health risks including liver damage and hormonal disruption, is banned in sports, and is not approved or recommended for use. We strongly advise against taking it.

Synthetic anabolic-androgenic steroid (not a plant) · Capsules, tablets

An interaction check asks whether these two react with each other — it does not ask whether Dymethazine is a good idea for someone in your situation. Here is what our Dymethazine record says about it on its own.

Dymethazine: dosing

There is no established or recommended safe dose for Dymethazine, because it is not an approved medicine or a legitimate dietary supplement. We do not provide dosing for it.Because it is an anabolic steroid with real health risks, the safest amount is none.

From our Dymethazine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Dymethazine monograph & all interactions
Medication

About Pimecrolimus Topical

What Is Pimecrolimus Topical Used For?

Brand name: Elidel

Pimecrolimus cream 1% is used to treat mild to moderate atopic dermatitis (eczema) in adults and children aged 2 and older. It is a second-line option — meaning it's tried when other topical prescription treatments haven't worked well enough, or when those treatments aren't a good fit.

It is intended for short-term and non-continuous use only, applied only to the affected areas. It is not approved for use in children under 2 years of age, and it should only be used in people with healthy immune systems.

Most-Reported Side Effects for Pimecrolimus

From FAERS, the FDA’s public side-effect reporting system (1,704 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dermatitis atopic 200 reports
Pruritus 193 reports
Rash 183 reports
Dry skin 101 reports
Eczema 97 reports
See full Pimecrolimus Topical drug information
Keep checking

Other Drugs & Dymethazine

Browse every other medication we’ve checked against Dymethazine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Dymethazine References

The 2 references that drive our Dymethazine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
  2. Agbenyefia P, Arnold CA, Kirkpatrick R 3rd. Cholestatic jaundice with the use of methylstenbolone and dymethazine, designer steroids found in super DMZ Rx 2.0 "Nutritional Supplement": A case report. J Investig Med High Impact Case Rep 2014;2(2):232470961 PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Dymethazine and Pimecrolimus Together: Common Questions

Is it safe to take Dymethazine with Pimecrolimus?
We do not list a known interaction between Dymethazine and Pimecrolimus. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Pimecrolimus interact with any supplements?
Yes. Pimecrolimus has documented interactions with 3 supplements in our database — Dymethazine is not one of them. The Pimecrolimus interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Pimecrolimus and Dymethazine?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.