Drug & supplement interaction

Euphorbia Hirta + Fosfomycin

Fosfomycin brand name: Monurol.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Euphorbia Hirta and Fosfomycin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Euphorbia Hirta and Fosfomycin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Fosfomycin and Euphorbia Hirta in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Euphorbia Hirta at all — not against Fosfomycin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Euphorbia Hirta safety at a glance

Euphorbia Hirta overall Use caution Human safety data are very limited, so use carefully and under professional guidance.
Pregnancy Possibly Unsafe When used orally; avoid using. Euphorbia hirta is reported to cause smooth muscle contraction and relaxation. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally; avoid using. Euphorbia hirta is reported to cause smooth muscle contraction and relaxation. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Fosfomycin and Euphorbia Hirta? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Euphorbia Hirta and Fosfomycin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Vomiting / Nausea Additional detail

    Euphorbia Hirta

    “There is currently a limited amount of information available about the adverse effects of Euphorbia hirta. Orally, Euphorbia hirta may cause nausea and vomiting (12). Topically, skin contact with fresh Euphorbia hirta can cause irritation or contact dermatitis (19).”

    Euphorbia Hirta · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    2. 19. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

    “Orally, Euphorbia hirta may cause nausea and vomiting (12).”

    Euphorbia Hirta · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

    Fosfomycin

    Listed in the ADVERSE REACTIONS section of the FDA label for Fosfomycin. Read the label on DailyMed ›

Reported for Euphorbia Hirta but not commonly for Fosfomycin: a skin rash.

Effects for Fosfomycin come from the ADVERSE REACTIONS section of its FDA label; effects for Euphorbia Hirta come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Euphorbia Hirta in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally; avoid using. Euphorbia hirta is reported to cause smooth muscle contraction and relaxation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Fosfomycin

This page covers Euphorbia Hirta only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fosfomycin page lists 44 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Bacillus Coagulans (moderate), Bacillus Subtilis (moderate), Bifidobacterium Animalis Subsp. Lactis (moderate) and Bifidobacterium Bifidum (moderate).

By severity: 1 major · 33 moderate · 10 minor.

From our pharmacist’s overview on the Fosfomycin page

“Fosfomycin (Monurol) is often given as a single sachet to knock out a bladder infection, so you get one chance to absorb the full dose, and that is exactly where this list deserves real care. The clearest hazard is activated charcoal, which binds medicines in the gut and can cut how much fosfomycin your body actually takes in.”

Reviewed by 2 · Jul 18, 2026

Open the Fosfomycin interaction page

How much people look this up

Where Euphorbia Hirta and Fosfomycin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Euphorbia Hirta
Steady interest

#1,073 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fosfomycin
Steady interest

#1,993 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Euphorbia Hirta reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Euphorbia Hirta and Fosfomycin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Euphorbia Hirta

What is Euphorbia Hirta?

  • Respiratory complaints like asthma and cough
  • Diarrhea and digestive upset
  • Skin wounds and warts
  • Worms and other parasites
  • General antimicrobial use

Euphorbia hirta is a small tropical weed used in traditional medicine for breathing problems, diarrhea, and skin issues. Most of its supposed benefits come from laboratory or animal studies rather than solid human trials, so its true effectiveness in people is unclear. Because its safety is not well studied, talk to a pharmacist or doctor before using it.

Euphorbia hirta · Euphorbiaceae · Whole plant (leaves, stems, flowers, and latex) · Dried herb, tea/decoction, tincture, capsules, and topical extracts

An interaction check asks whether these two react with each other — it does not ask whether Euphorbia Hirta is a good idea for someone in your situation. Here is what our Euphorbia Hirta record says about it on its own.

Euphorbia Hirta: dosing

There is no standardized or well-established dose for Euphorbia hirta. Traditional preparations vary widely depending on the form (tea, juice, tincture, or capsule) and the region.Because product strength and purity can differ a lot between brands, follow the directions on the product label and do not exceed them.

From our Euphorbia Hirta monograph — the full record covers uses, side effects and every documented interaction.

Read the full Euphorbia Hirta monograph & all interactions
Medication

About Fosfomycin

What Is Fosfomycin Used For?

Brand name: Monurol

Fosfomycin is an antibiotic used to treat urinary tract infections (UTIs) caused by specific bacteria. The right form depends on how serious the infection is.

Oral forms (Fosfomycin Tromethamine and Monurol) are approved only for uncomplicated UTIs — also called acute cystitis — in women 18 and older, caused by E. coli or Enterococcus faecalis. They are not for kidney infections or abscesses around the kidney. Contepo (intravenous) is approved for adults 18 and older with complicated UTIs, including acute pyelonephritis (kidney infection), caused by susceptible E. coli or Klebsiella pneumoniae.

See full Fosfomycin drug information
Keep checking

Other Drugs & Euphorbia Hirta

Browse every other medication we’ve checked against Euphorbia Hirta — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Euphorbia Hirta against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Euphorbia Hirta list.

See the full Euphorbia Hirta interactions page
See every supplement checked against Fosfomycin, ranked by severity
Evidence & sources

Euphorbia Hirta References

The 3 references that drive our Euphorbia Hirta monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Euphorbia Hirta and Fosfomycin Together: Common Questions

Is it safe to take Euphorbia Hirta with Fosfomycin?
We do not list a known interaction between Euphorbia Hirta and Fosfomycin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Euphorbia Hirta and Fosfomycin have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Fosfomycin interact with any supplements?
Yes. Fosfomycin has documented interactions with 44 supplements in our database — Euphorbia Hirta is not one of them. The Fosfomycin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Euphorbia Hirta monograph Uses, safety profile, and every drug interaction in one place Fosfomycin drug information The full plain-English guide to this medication Fosfomycin supplement interactions Every supplement checked against Fosfomycin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Fosfomycin and Euphorbia Hirta?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.