Drug & supplement interaction

Fadogia Agrestis + Tasimelteon

Tasimelteon brand names: Hetlioz, Hetlioz Lq.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Fadogia Agrestis and Tasimelteon in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Tasimelteon states a food rule worth keeping to.

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Interaction report

Fadogia Agrestis and Tasimelteon

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tasimelteon and Fadogia Agrestis in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Fadogia Agrestis at all — not against Tasimelteon, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Fadogia Agrestis safety at a glance

Fadogia Agrestis overall Use caution Human safety data are lacking and animal studies suggest possible toxicity to the testicles, liver, and kidneys.
Pregnancy Avoid No safety data exist, so it should be avoided during pregnancy.
Breastfeeding Avoid No safety data exist, so it should be avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tasimelteon and Fadogia Agrestis? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Tasimelteon’s Own FDA Label Lists

This is not an interaction — none of it involves Fadogia Agrestis. These are the most notable effects listed in the ADVERSE REACTIONS section of Tasimelteon’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 2 of them are worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on
  • A higher chance of infection Worth acting on
  • Vivid dreams or nightmares mentioned in 8.5% of FDA reports for Tasimelteon
  • Trouble sleeping mentioned in 19.8% of FDA reports for Tasimelteon
  • Headache mentioned in 6.7% of FDA reports for Tasimelteon

From the ADVERSE REACTIONS section of the FDA label for Tasimelteon. Read the label on DailyMed › Where a percentage is shown, it is the share of 5,765 voluntary FDA FAERS reports for Tasimelteon that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Fadogia Agrestis’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Fadogia Agrestis side to compare — that is a limit of the record, not a statement that Fadogia Agrestis has no side effects.

How to take them

Some Tasimelteon Products Have a Food Rule — Fadogia Agrestis Should Not Break It

At least one FDA label for a product containing Tasimelteon says to take it on an empty stomach. Most supplements — Fadogia Agrestis included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Tasimelteon on its own and move Fadogia Agrestis to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Tasimelteon products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Indicated Population Dosage Form Body Weight Recommended Dosage Non-24 ( 2.2 ) Adults Capsules Not applicable 20 mg one hour prior to bedtime Nighttime sleep disturbances in SMS ( 2.3 ) Patients 16 years of age and older Capsules Not applicable 20 mg one hour prior to bedtime Pediatric Patients 3 to 15 years of age Oral Suspension ≤ 28 kg 0.7 mg/kg one hour before bedti

From the Dosage and Administration section of the FDA label we read for Tasimelteon — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Tasimelteon

This page covers Fadogia Agrestis only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tasimelteon page lists 218 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 166 moderate · 43 minor.

From our pharmacist’s overview on the Tasimelteon page

“Tasimelteon (Hetlioz) resets the body clock in people with non-24-hour sleep-wake disorder, and the sleep aids they often reach for, melatonin and kava among them, sit on an interaction list that deserves real respect. Nine of the 218 ingredients on file rate major, mostly in two directions: sedatives like kava stack drowsiness onto a…”

Reviewed by 2 · Jul 18, 2026

Open the Tasimelteon interaction page

One more smart check

Taking Fadogia Agrestis as Part of a Dietary Supplement Product? Check It for Interactions

We hold 59 real supplement products containing Fadogia Agrestis, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Fadogia Agrestis. Even though Fadogia Agrestis itself has no known interaction with Tasimelteon, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Fadogia Agrestis and Tasimelteon Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Fadogia Agrestis
Steady interest

#767 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tasimelteon
Steady interest

#1,943 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Fadogia Agrestis is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Fadogia Agrestis reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Fadogia Agrestis and Tasimelteon records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Fadogia Agrestis

What is Fadogia Agrestis?

  • Boosting testosterone
  • Improving libido and sexual function
  • Athletic performance and muscle building
  • Traditional African remedy for various ailments

Fadogia agrestis is a West African shrub marketed as a testosterone booster, but human evidence is essentially nonexistent and what we know comes mostly from a few small rat studies. Animal data raise real concerns about organ toxicity, so the safety of long-term use in people is unknown. Talk with your pharmacist or doctor before trying it, and avoid it if you are pregnant, breastfeeding, or have any underlying health conditions.

Fadogia agrestis · Rubiaceae · Stem (and sometimes leaves and roots) · Capsules, powders, and tinctures (often sold as a standardized extract)

An interaction check asks whether these two react with each other — it does not ask whether Fadogia Agrestis is a good idea for someone in your situation. Here is what our Fadogia Agrestis record says about it on its own.

Fadogia Agrestis: dosing

There is no established or proven safe dose of Fadogia agrestis for humans. The doses used in supplements are based on animal studies and manufacturer choices, not on human research.If you choose to use a product, follow the directions on the label and do not exceed them.

From our Fadogia Agrestis monograph — the full record covers uses, side effects and every documented interaction.

Read the full Fadogia Agrestis monograph & all interactions
Medication

About Tasimelteon

What Is Tasimelteon Used For?

Brand names: Hetlioz, Hetlioz Lq

Tasimelteon capsules are approved to treat Non-24-Hour Sleep-Wake Disorder (Non-24) in adults. Non-24 is a condition where the body's internal clock does not align with the normal 24-hour day, causing sleep and wake times to shift continuously.

Hetlioz capsules are also approved to treat nighttime sleep disturbances in Smith-Magenis Syndrome (SMS) in patients 16 years of age and older. Hetlioz LQ oral suspension is approved specifically for nighttime sleep disturbances in SMS in pediatric patients ages 3 to 15 years.

Most-Reported Side Effects for Tasimelteon

From FAERS, the FDA’s public side-effect reporting system (5,770 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Insomnia 728 reports
Middle insomnia 414 reports
Somnolence 408 reports
Headache 386 reports
Nightmare 268 reports
See full Tasimelteon drug information
Keep checking

Other Drugs & Fadogia Agrestis

Browse every other medication we’ve checked against Fadogia Agrestis — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Fadogia Agrestis against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Fadogia Agrestis list.

See the full Fadogia Agrestis interactions page
See every supplement checked against Tasimelteon, ranked by severity
Evidence & sources

Fadogia Agrestis References

The 2 sources that drive our Fadogia Agrestis monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Fadogia Agrestis is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Fadogia Agrestis and Tasimelteon Together: Common Questions

Is it safe to take Fadogia Agrestis with Tasimelteon?
We do not list a known interaction between Fadogia Agrestis and Tasimelteon. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Fadogia Agrestis and Tasimelteon at the same time of day?
At least one FDA label for a product containing Tasimelteon says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Tasimelteon on its own and move Fadogia Agrestis to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Does Tasimelteon interact with any supplements?
Yes. Tasimelteon has documented interactions with 218 supplements in our database — Fadogia Agrestis is not one of them. The Tasimelteon interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Fadogia Agrestis monograph Uses, safety profile, and every drug interaction in one place Tasimelteon drug information The full plain-English guide to this medication Tasimelteon supplement interactions Every supplement checked against Tasimelteon, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tasimelteon and Fadogia Agrestis?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.