Drug & supplement interaction

Feingold Diet + Macitentan

Macitentan brand name: Opsumit.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Feingold Diet and Macitentan in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Feingold Diet and Macitentan

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Macitentan and Feingold Diet in our sources. This does not guarantee that the combination is completely free of risk — research on Feingold Diet alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Feingold Diet at all — not against Macitentan, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Feingold Diet is an eating pattern rather than something you take. Ask your pharmacist or doctor before changing how you eat while on a prescribed medicine: some medicines are dosed around meals, and a change in diet can change how they work. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Feingold Diet safety at a glance

Feingold Diet overall Use caution Generally low risk, but restrictive diets in children can lead to nutrition gaps if not supervised.
Pregnancy Use caution The diet is aimed at children; pregnant people should not follow restrictive diets without medical guidance.
Breastfeeding Use caution Restricting your own diet while breastfeeding is not recommended without a clinician's advice.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Macitentan and Feingold Diet? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Macitentan’s Own FDA Label Lists

This is not an interaction — none of it involves Feingold Diet. These are the most notable effects listed in the ADVERSE REACTIONS section of Macitentan’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you follow Feingold Diet and take the medicine. 6 of them are worth acting on rather than waiting out — marked below.

  • Heart failure Worth acting on
  • Anemia Worth acting on
  • A severe allergic reaction Worth acting on
  • A higher chance of infection Worth acting on mentioned in 6.6% of FDA reports for Macitentan
  • Liver problems Worth acting on
  • An allergic reaction Worth acting on
  • Flushing
  • A stuffy or runny nose
  • Sore throat
  • Low blood pressure

Showing the 10 most notable of 14 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Macitentan. Read the label on DailyMed › Where a percentage is shown, it is the share of 68,860 voluntary FDA FAERS reports for Macitentan that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Feingold Diet’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Feingold Diet side to compare — that is a limit of the record, not a statement that Feingold Diet has no side effects.

Everything else you take

See Every Supplement That Interacts With Macitentan

This page covers Feingold Diet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Macitentan page lists 253 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Beer (major) and Grapefruit (major).

By severity: 9 major · 205 moderate · 39 minor.

From our pharmacist’s overview on the Macitentan page

“If you take macitentan (Opsumit) for pulmonary arterial hypertension, study this page rather than skim it. It lists 253 supplement and herbal ingredients, nine rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Macitentan interaction page

How much people look this up

Where Feingold Diet and Macitentan Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Feingold Diet
Steady interest

#1,232 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Macitentan
Top 25%

#598 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Feingold Diet reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Feingold Diet and Macitentan records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Eating pattern

About Feingold Diet

What is Feingold Diet?

  • Hyperactivity (ADHD) in children
  • Behavioral problems in kids
  • Attention and focus concerns
  • Childhood sleep and mood issues

The Feingold Diet is an elimination eating plan that removes certain artificial food colors, flavors, sweeteners, preservatives, and some natural salicylate-containing foods, mainly to reduce hyperactivity in children. Scientific evidence is mixed and limited, though a small number of children may be sensitive to specific food additives. If you try it, work with a pediatrician or registered dietitian so your child still gets balanced nutrition.

Elimination diet / structured eating plan

An interaction check asks whether these two react with each other — it does not ask whether Feingold Diet is a good idea for someone in your situation. Here is what our Feingold Diet record says about it on its own.

Feingold Diet: dosing

There is no pill or standardized "dose" for the Feingold Diet — it is a pattern of eating. It is typically done in phases: a stricter starting period that removes targeted additives and salicylate-rich foods, followed by gradual reintroduction to identify specific triggers.Because the diet can be complex and restrictive, it is best to follow program guidance and work with a registered dietitian or pediatrician to make sure your child's overall diet stays balanced.

From our Feingold Diet monograph — the full record covers uses, side effects and every documented interaction.

Read the full Feingold Diet monograph & all interactions
Medication

About Macitentan

What Is Macitentan Used For?

Brand name: Opsumit

Macitentan tablets — sold under the brand name Opsumit — are used to treat pulmonary arterial hypertension (PAH, WHO Group I), a type of high blood pressure in the arteries of the lungs. The goal is to slow the disease from getting worse and to lower the chance of being hospitalized because of PAH.

In the key clinical study, macitentan was used in adults with mainly moderate-to-severe PAH symptoms. Patients had PAH caused by unknown or inherited causes, connective tissue disorders, or congenital heart disease with repaired shunts.

Most-Reported Side Effects for Macitentan

From FAERS, the FDA’s public side-effect reporting system (68,860 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 11,958 reports
Headache 8,323 reports
Diarrhea 6,584 reports
Nausea 5,972 reports
Fatigue 5,041 reports
See full Macitentan drug information
Keep checking

Other Drugs & Feingold Diet

Browse every other medication we’ve checked against Feingold Diet — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Feingold Diet against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Feingold Diet list.

See the full Feingold Diet interactions page
See every supplement checked against Macitentan, ranked by severity
Evidence & sources

Feingold Diet References

The 2 references that drive our Feingold Diet monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Conners CK, Goyette CH, Southwick DA, et al. Food additives and hyperkinesis: a controlled double-blind experiment. Pediatrics 1976;58:154-66. DOI
  2. Harley JP, Ray RS, Tomasi L, et al. Hyperkinesis and food additives: testing the Feingold hypothesis. Pediatrics 1978;61:818-28. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Following Feingold Diet While Taking Macitentan: Common Questions

Is it safe to follow Feingold Diet while taking Macitentan?
We do not list a known interaction between Feingold Diet and Macitentan. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Macitentan interact with any supplements?
Yes. Macitentan has documented interactions with 253 supplements in our database — Feingold Diet is not one of them. The Macitentan interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Feingold Diet monograph Uses, safety profile, and every drug interaction in one place Macitentan drug information The full plain-English guide to this medication Macitentan supplement interactions Every supplement checked against Macitentan, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Macitentan and Feingold Diet?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.