Drug & supplement interaction

Ficin + Amphetamine

Amphetamine brand names: Dyanavel XR, Adensys XR-ODT, Mydayis, Adzenys ER.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Ficin and Amphetamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Ficin and Amphetamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Amphetamine and Ficin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Ficin at all — not against Amphetamine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ficin safety at a glance

Ficin overall Use caution Human safety data are limited, and the crude latex can irritate skin and the digestive tract.
Pregnancy Likely Unsafe When crude ficin (latex) is used orally or topically. Serious adverse effects, including vomiting, seizures, and coma, have been reported in non-pregnant adults... Read the full pregnancy detail
Breastfeeding Likely Unsafe When crude ficin (latex) is used orally or topically. Serious adverse effects, including vomiting, seizures, and coma, have been reported in non-pregnant adults... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Amphetamine and Ficin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Ficin Itself Has Been Linked To

This is not an interaction — nothing below involves Amphetamine. It is the side-effect record for Ficin on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Ficin, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Seizures Worth acting on Additional detail

    “Orally, taking large amounts of crude ficin (latex) can cause nausea, vomiting, psychomotor excitation, coma, seizures, diarrhea, headache, abdominal discomfort, somnolence, mydriasis, cerebral edema, and even death (11,100608).

    Topically, crude ficin (latex) is corrosive to skin and can cause bleeding with prolonged contact. Ficin can also cause contact allergies (11).”

    Ficin · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    2 sources cited
    1. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
    2. 100608. Hansson A, Zelada JC, Noriega HP. Reevaluation of risks with the use of Ficus insipida latex as a traditional anthelmintic remedy in the Amazon. J Ethnopharmacol 2005;98(3):251-7. PubMed

    “Orally, taking large amounts of crude ficin (latex) can cause psychomotor excitation, coma, seizures, headache, somnolence, cerebral edema, and even death. In a retrospective chart review, 94% of children and 85% of adults admitted to a hospital in Peru after taking a traditional crude ficin (latex) preparation had CNS-related adverse effects, the most common being psychomotor excitation, coma, and seizures.”

    Ficin · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 100608. Hansson A, Zelada JC, Noriega HP. Reevaluation of risks with the use of Ficus insipida latex as a traditional anthelmintic remedy in the Amazon. J Ethnopharmacol 2005;98(3):251-7. PubMed
  • Bleeding or bruising Worth acting on Additional detail

    “Topically, crude ficin (latex) is corrosive to skin and can cause bleeding with prolonged contact. Ficin can also cause contact allergies (11).”

    Ficin · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    1 source cited
    1. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  • Drowsiness / Swelling / Headache Additional detail

    Recorded for Ficin in the same Natural Medicines adverse-effect record shown under Seizures above.

  • Stomach upset / Diarrhea / Vomiting / Nausea Additional detail

    “Orally, taking large amounts of crude ficin (latex) can cause nausea, vomiting, diarrhea, and abdominal discomfort (11,100608). In a retrospective chart review, 63% of children and 69% of adults admitted to a hospital in Peru after taking a traditional crude ficin (latex) preparation had gastrointestinal adverse effects, the most common being nausea and vomiting.”

    Ficin · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
    2. 100608. Hansson A, Zelada JC, Noriega HP. Reevaluation of risks with the use of Ficus insipida latex as a traditional anthelmintic remedy in the Amazon. J Ethnopharmacol 2005;98(3):251-7. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Ficin — expand a row for the licensed statement it rests on. We haven’t matched Amphetamine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Amphetamine.

Special populations

Ficin in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When crude ficin (latex) is used orally or topically. Serious adverse effects, including vomiting, seizures, and coma, have been reported in non-pregnant adults taking traditional ficin preparations orally at a dose of 1.5 cm3/kg or higher. Theoretically, taking crude ficin orally might cause harm to pregnant women, nursing infants, or unborn fetuses, avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Ficin or Amphetamine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Ficin or Amphetamine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Amphetamine

This page covers Ficin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amphetamine page lists 130 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Bitter Orange (major), Brewer's Yeast (major) and Cowhage (major).

By severity: 16 major · 97 moderate · 17 minor.

From our pharmacist’s overview on the Amphetamine page

“Amphetamine (Dyanavel XR, Adzenys ER, Mydayis) is a prescription stimulant, usually taken for ADHD, and its interaction list is one to approach with genuine care. Of the 130 supplements and herbal ingredients on file, 16 carry a major rating, and many of those work the same way, either inhibiting monoamine oxidase, as yohimbe does, or…”

Reviewed by 2 · Jul 18, 2026

Open the Amphetamine interaction page

One more smart check

Taking Ficin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4 real supplement products containing Ficin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ficin. Even though Ficin itself has no known interaction with Amphetamine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ficin and Amphetamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ficin
Steady interest

#1,253 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amphetamine
Top 5%

#46 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ficin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Ficin and Amphetamine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ficin

What is Ficin?

Ficin
  • Intestinal worms (helminth infections)
  • Digestive aid (protein digestion)
  • Anti-inflammatory uses
  • Wound and skin applications (traditional)
  • As a meat tenderizer and food preservative

Ficin is a protein-digesting enzyme from the latex of the tropical fig tree Ficus insipida. It has a long history of traditional use for intestinal worms and is studied in labs for breaking down proteins and bacterial biofilms, but solid human evidence for any health use is limited. The crude latex can be irritating and is not well-studied for safety, so talk with a pharmacist or doctor before using it.

Ficus insipida · Moraceae · Latex (milky sap) from the trunk; purified enzyme extracted from the latex · Crude latex, purified enzyme preparations (powders), and as an ingredient in some research or industrial products

An interaction check asks whether these two react with each other — it does not ask whether Ficin is a good idea for someone in your situation. Here is what our Ficin record says about it on its own.

Ficin: dosing

There is no established standard dose for Ficin. Traditional preparations of the latex vary widely, and there is no agreed-upon safe and effective amount for any health use.If you are considering a commercial product that contains ficin, follow the directions on the label and do not exceed them.

From our Ficin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ficin monograph & all interactions
Medication

About Amphetamine

What Is Amphetamine Used For?

Brand names: Dyanavel XR, Adensys XR-ODT, Mydayis, Adzenys ER

Amphetamine treats Attention Deficit Hyperactivity Disorder (ADHD) in patients 6 years and older. Adzenys XR-ODT, Dyanavel XR, and the amphetamine extended-release orally disintegrating tablet formulations are specifically approved for ADHD in this age group.

Amphetamine Sulfate tablets and Evekeo (amphetamine sulfate tablets) are also approved for narcolepsy (a sleep disorder causing uncontrollable daytime sleepiness) and as a short-term aid in a calorie-restricted weight-loss program for exogenous obesity (weight gain from external factors like overeating) in patients who have not responded to other approaches.

See full Amphetamine drug information
Keep checking

Other Drugs & Ficin

Browse every other medication we’ve checked against Ficin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Ficin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Ficin list.

See the full Ficin interactions page
See every supplement checked against Amphetamine, ranked by severity
Evidence & sources

Ficin References

The 3 references that drive our Ficin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Hansson A, Zelada JC, Noriega HP. Reevaluation of risks with the use of Ficus insipida latex as a traditional anthelmintic remedy in the Amazon. J Ethnopharmacol 2005;98(3):251-7. PubMed
  3. Ma JW, Hung JL, Takeuchi M, Shieh PC, Horng CT. A New Pharmacological Vitreolysis through the Supplement of Mixed Fruit Enzymes for Patients with Ocular Floaters or Vitreous Hemorrhage-Induced Floaters. J Clin Med 2022;11(22):6710. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ficin and Amphetamine Together: Common Questions

Is it safe to take Ficin with Amphetamine?
We do not list a known interaction between Ficin and Amphetamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Amphetamine interact with any supplements?
Yes. Amphetamine has documented interactions with 130 supplements in our database — Ficin is not one of them. The Amphetamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ficin monograph Uses, safety profile, and every drug interaction in one place Amphetamine drug information The full plain-English guide to this medication Amphetamine supplement interactions Every supplement checked against Amphetamine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Amphetamine and Ficin?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.