Drug & supplement interaction

Ficin + Sofosbuvir, Velpatasvir, Voxilaprevir

Sofosbuvir, Velpatasvir, Voxilaprevir brand name: Vosevi.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Ficin and Sofosbuvir, Velpatasvir, Voxilaprevir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Sofosbuvir, Velpatasvir, Voxilaprevir states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Ficin and Sofosbuvir, Velpatasvir, Voxilaprevir

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sofosbuvir, Velpatasvir, Voxilaprevir and Ficin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Ficin at all — not against Sofosbuvir, Velpatasvir, Voxilaprevir, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ficin safety at a glance

Ficin overall Use caution Human safety data are limited, and the crude latex can irritate skin and the digestive tract.
Pregnancy Likely Unsafe When crude ficin (latex) is used orally or topically. Serious adverse effects, including vomiting, seizures, and coma, have been reported in non-pregnant adults... Read the full pregnancy detail
Breastfeeding Likely Unsafe When crude ficin (latex) is used orally or topically. Serious adverse effects, including vomiting, seizures, and coma, have been reported in non-pregnant adults... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sofosbuvir, Velpatasvir, Voxilaprevir and Ficin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Ficin and Sofosbuvir, Velpatasvir, Voxilaprevir May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Swelling / Headache Additional detail

    Ficin

    “Orally, taking large amounts of crude ficin (latex) can cause nausea, vomiting, psychomotor excitation, coma, seizures, diarrhea, headache, abdominal discomfort, somnolence, mydriasis, cerebral edema, and even death (11,100608).

    Topically, crude ficin (latex) is corrosive to skin and can cause bleeding with prolonged contact. Ficin can also cause contact allergies (11).”

    Ficin · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    2 sources cited
    1. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
    2. 100608. Hansson A, Zelada JC, Noriega HP. Reevaluation of risks with the use of Ficus insipida latex as a traditional anthelmintic remedy in the Amazon. J Ethnopharmacol 2005;98(3):251-7. PubMed

    “Orally, taking large amounts of crude ficin (latex) can cause psychomotor excitation, coma, seizures, headache, somnolence, cerebral edema, and even death. In a retrospective chart review, 94% of children and 85% of adults admitted to a hospital in Peru after taking a traditional crude ficin (latex) preparation had CNS-related adverse effects, the most common being psychomotor excitation, coma, and seizures.”

    Ficin · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 100608. Hansson A, Zelada JC, Noriega HP. Reevaluation of risks with the use of Ficus insipida latex as a traditional anthelmintic remedy in the Amazon. J Ethnopharmacol 2005;98(3):251-7. PubMed

    Sofosbuvir, Velpatasvir, Voxilaprevir

    Listed in the ADVERSE REACTIONS section of the FDA label for Sofosbuvir, Velpatasvir, Voxilaprevir. Read the label on DailyMed ›

  • Diarrhea / Nausea Additional detail

    Ficin

    “Orally, taking large amounts of crude ficin (latex) can cause nausea, vomiting, diarrhea, and abdominal discomfort (11,100608). In a retrospective chart review, 63% of children and 69% of adults admitted to a hospital in Peru after taking a traditional crude ficin (latex) preparation had gastrointestinal adverse effects, the most common being nausea and vomiting.”

    Ficin · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
    2. 100608. Hansson A, Zelada JC, Noriega HP. Reevaluation of risks with the use of Ficus insipida latex as a traditional anthelmintic remedy in the Amazon. J Ethnopharmacol 2005;98(3):251-7. PubMed

    Sofosbuvir, Velpatasvir, Voxilaprevir

    Listed in the ADVERSE REACTIONS section of the FDA label for Sofosbuvir, Velpatasvir, Voxilaprevir. Read the label on DailyMed ›

Reported for Ficin but not commonly for Sofosbuvir, Velpatasvir, Voxilaprevir: stomach upset, drowsiness, vomiting and seizures.

Effects for Sofosbuvir, Velpatasvir, Voxilaprevir come from the ADVERSE REACTIONS section of its FDA label; effects for Ficin come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Ficin in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When crude ficin (latex) is used orally or topically. Serious adverse effects, including vomiting, seizures, and coma, have been reported in non-pregnant adults taking traditional ficin preparations orally at a dose of 1.5 cm3/kg or higher. Theoretically, taking crude ficin orally might cause harm to pregnant women, nursing infants, or unborn fetuses, avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Sofosbuvir, Velpatasvir, Voxilaprevir Products Have a Food Rule — Ficin Should Not Break It

At least one FDA label for a product containing Sofosbuvir, Velpatasvir, Voxilaprevir says to take it with food. If you take Ficin on an empty stomach out of habit, keep them separate — and take Sofosbuvir, Velpatasvir, Voxilaprevir with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Sofosbuvir, Velpatasvir, Voxilaprevir products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.1 ) Recommended dosage: One tablet (400 mg of sofosbuvir, 100 mg of velpatasvir, and 100 mg of voxilaprevir) taken orally once daily with food.

From the Dosage and Administration section of the FDA label we read for Sofosbuvir, Velpatasvir, Voxilaprevir — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Sofosbuvir, Velpatasvir, Voxilaprevir

This page covers Ficin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sofosbuvir, Velpatasvir, Voxilaprevir page lists 173 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 130 moderate · 40 minor.

From our pharmacist’s overview on the Sofosbuvir, Velpatasvir, Voxilaprevir page

“Vosevi (sofosbuvir, velpatasvir, and voxilaprevir) cures hepatitis C over a single short course, and that is exactly why I would be genuinely careful with supplements while taking it. Anything that drags its blood levels down can cost you the cure itself.”

Reviewed by 2 · Jul 18, 2026

Open the Sofosbuvir, Velpatasvir, Voxilaprevir interaction page

One more smart check

Taking Ficin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4 real supplement products containing Ficin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ficin. Even though Ficin itself has no known interaction with Sofosbuvir, Velpatasvir, Voxilaprevir, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ficin and Sofosbuvir, Velpatasvir, Voxilaprevir Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ficin
Steady interest

#1,253 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sofosbuvir, Velpatasvir, Voxilaprevir
Steady interest

#2,245 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ficin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Ficin and Sofosbuvir, Velpatasvir, Voxilaprevir records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ficin

What is Ficin?

Ficin
  • Intestinal worms (helminth infections)
  • Digestive aid (protein digestion)
  • Anti-inflammatory uses
  • Wound and skin applications (traditional)
  • As a meat tenderizer and food preservative

Ficin is a protein-digesting enzyme from the latex of the tropical fig tree Ficus insipida. It has a long history of traditional use for intestinal worms and is studied in labs for breaking down proteins and bacterial biofilms, but solid human evidence for any health use is limited. The crude latex can be irritating and is not well-studied for safety, so talk with a pharmacist or doctor before using it.

Ficus insipida · Moraceae · Latex (milky sap) from the trunk; purified enzyme extracted from the latex · Crude latex, purified enzyme preparations (powders), and as an ingredient in some research or industrial products

An interaction check asks whether these two react with each other — it does not ask whether Ficin is a good idea for someone in your situation. Here is what our Ficin record says about it on its own.

Ficin: dosing

There is no established standard dose for Ficin. Traditional preparations of the latex vary widely, and there is no agreed-upon safe and effective amount for any health use.If you are considering a commercial product that contains ficin, follow the directions on the label and do not exceed them.

From our Ficin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ficin monograph & all interactions
Medication

About Sofosbuvir, Velpatasvir, and Voxilaprevir

What Is Sofosbuvir, Velpatasvir, and Voxilaprevir Used For?

Brand name: Vosevi

Vosevi is used to treat chronic hepatitis C virus (HCV) infection in adults who do not have cirrhosis or who have compensated cirrhosis (mild liver scarring that is still functioning). It is specifically for people who have already been treated with an HCV regimen before and need a different option.

Vosevi is approved for adults with HCV genotype 1, 2, 3, 4, 5, or 6 who previously took a medicine that included an NS5A inhibitor. It is also approved for adults with genotype 1a or 3 who previously took sofosbuvir without an NS5A inhibitor.

See full Sofosbuvir, Velpatasvir, and Voxilaprevir drug information
Keep checking

Other Drugs & Ficin

Browse every other medication we’ve checked against Ficin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Ficin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Ficin list.

See the full Ficin interactions page
See every supplement checked against Sofosbuvir, Velpatasvir, Voxilaprevir, ranked by severity
Evidence & sources

Ficin References

The 3 references that drive our Ficin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Hansson A, Zelada JC, Noriega HP. Reevaluation of risks with the use of Ficus insipida latex as a traditional anthelmintic remedy in the Amazon. J Ethnopharmacol 2005;98(3):251-7. PubMed
  3. Ma JW, Hung JL, Takeuchi M, Shieh PC, Horng CT. A New Pharmacological Vitreolysis through the Supplement of Mixed Fruit Enzymes for Patients with Ocular Floaters or Vitreous Hemorrhage-Induced Floaters. J Clin Med 2022;11(22):6710. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ficin and Sofosbuvir, Velpatasvir, Voxilaprevir Together: Common Questions

Is it safe to take Ficin with Sofosbuvir, Velpatasvir, Voxilaprevir?
We do not list a known interaction between Ficin and Sofosbuvir, Velpatasvir, Voxilaprevir. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Ficin and Sofosbuvir, Velpatasvir, Voxilaprevir have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Ficin and Sofosbuvir, Velpatasvir, Voxilaprevir at the same time of day?
At least one FDA label for a product containing Sofosbuvir, Velpatasvir, Voxilaprevir says to take it with food. If you take Ficin on an empty stomach out of habit, keep them separate and take Sofosbuvir, Velpatasvir, Voxilaprevir with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Sofosbuvir, Velpatasvir, Voxilaprevir products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Sofosbuvir, Velpatasvir, Voxilaprevir interact with any supplements?
Yes. Sofosbuvir, Velpatasvir, Voxilaprevir has documented interactions with 173 supplements in our database — Ficin is not one of them. The Sofosbuvir, Velpatasvir, Voxilaprevir interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ficin monograph Uses, safety profile, and every drug interaction in one place Sofosbuvir, Velpatasvir, and Voxilaprevir drug information The full plain-English guide to this medication Sofosbuvir, Velpatasvir, Voxilaprevir supplement interactions Every supplement checked against Sofosbuvir, Velpatasvir, Voxilaprevir, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sofosbuvir, Velpatasvir, Voxilaprevir and Ficin?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.