Drug & supplement interaction

Fish Therapy + Psyllium (OTC drug)

Psyllium (OTC drug) brand name: Metamucil.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Fish Therapy and Psyllium (OTC drug) in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone interested in this? Share
Facebook Post Reddit Email
On this page
Interaction report

Fish Therapy and Psyllium (OTC drug)

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Psyllium (OTC drug) and Fish Therapy in our sources. This does not guarantee that the combination is completely free of risk — research on Fish Therapy alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Fish Therapy at all — not against Psyllium (OTC drug), and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Fish Therapy is a treatment rather than something you take. Tell whoever provides it which medicines you use, and ask your prescriber whether it is appropriate for your health and treatment. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Fish Therapy safety at a glance

Fish Therapy overall Use caution Hygiene and infection risks make this a cautious choice, especially with shared water.
Pregnancy Use caution Not studied in pregnancy; avoid due to infection risk unless cleared by your doctor.
Breastfeeding Use caution No safety data; infection risk makes caution reasonable while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Psyllium (OTC drug) and Fish Therapy? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Fish Therapy Itself Has Been Linked To

This is not an interaction — nothing below involves Psyllium (OTC drug). It is the side-effect record for Fish Therapy on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Fish Therapy, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Liver problems / A higher chance of infection Worth acting on Additional detail

    “Multiple case reports suggest that fish therapy can increase the risk for bacterial infection. Studies of fish therapy water have identified multiple bacteria capable of causing disease. It is currently not possible to adequately sterilize the water without killing the fish. Additionally, when performed in a spa or salon setting, pedicure tubs cannot be adequately cleaned when fish are present.”

    Fish Therapy · Natural Medicines adverse-effect record, reported in dermatitis.

    6 sources cited
    1. 103109. Vanhooteghem O, Anseeuw D, Michel C, et al. Fish Pedicure-induced Aeromonas sobria Superficial Necrotic Bullous Dermatitis in a Previously Undiagnosed Diabetes Patient. What are the Risks of Fish Pedicure for Public Health? BJMMR. 2015;10(12):1-10. DOI
    2. 103110. Veraldi S, Nazzaro G, Çuka E. Staphylococcus aureus infection of the feet following fish pedicure. Infection. 2014 Oct;42(5):925-6. PubMed
    3. 103111. Sugimoto K, Frei R, Graber P. Methicillin-resistant Staphylococcus aureus foot infection after fish pedicure. Infection. 2013 Oct;41(5):1013-5. PubMed
    4. 103112. Vanhooteghem O, Theate I. Fish pedicure-induced foot mycobacteriosis infection due to Mycobacterium marinum: a first case report. Eur J Dermatol. 2017 Jun 1;27(3):299-300. PubMed
    5. 103108. Lipner SR. Onychomadesis Following a Fish Pedicure. JAMA Dermatol. 2018 Sep 1;154(9):1091-1092. PubMed
    6. 103113. US Centers for Disease Control (CDC). Fish Pedicures and Fish Spas. August 2, 2016. Available at: https://www.cdc.gov/healthywater/hygiene/body/fish_pedicures.html. Accessed on June 15, 2020.
  • Swelling / A skin rash Additional detail

    Recorded for Fish Therapy in the same Natural Medicines adverse-effect record shown under Liver problems / A higher chance of infection above.

Everything above comes from the Natural Medicines adverse-effect record for Fish Therapy — expand a row for the licensed statement it rests on. We haven’t matched Psyllium (OTC drug) to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Psyllium (OTC drug).

From our Q&A

Questions About Fish Therapy or Psyllium (OTC drug)

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Fish Therapy or Psyllium (OTC drug), not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Psyllium (OTC drug)

This page covers Fish Therapy only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Psyllium (OTC drug) page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Psyllium (OTC drug) page

“Activated charcoal tops the psyllium (Metamucil) list and is the one entry rated major. Charcoal binds many medicines in the gut and can cut how much of them reaches the body, so pairing it with anything you take by mouth deserves real caution, and I would read that entry before the rest.”

Reviewed by 2 · Jul 18, 2026

Open the Psyllium (OTC drug) interaction page

How much people look this up

Where Fish Therapy and Psyllium (OTC drug) Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Fish Therapy
Steady interest

#1,100 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Psyllium (OTC drug)
Top half

#1,087 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Fish Therapy reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Fish Therapy and Psyllium (OTC drug) records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Treatment approach

About Fish Therapy

What is Fish Therapy?

  • Psoriasis
  • Skin exfoliation and smoothing
  • Eczema and dry skin
  • Cosmetic foot care (pedicure)
  • General relaxation

Fish therapy (also called ichthyotherapy or a 'fish pedicure') uses small Garra rufa fish to nibble away dead skin, and it is mostly used cosmetically or for skin conditions like psoriasis. Evidence that it treats any medical condition is very limited, and there are real infection and hygiene concerns. If you have a skin condition, talk with a dermatologist before trying it.

Live fish (commonly Garra rufa); the whole animal used in skin-immersion baths · Spa fish baths (foot or full-body immersion with Garra rufa fish)

An interaction check asks whether these two react with each other — it does not ask whether Fish Therapy is a good idea for someone in your situation. Here is what our Fish Therapy record says about it on its own.

Fish Therapy: dosing

There is no standard 'dose' for fish therapy, since it is a spa procedure rather than a supplement you take. Sessions are usually a set number of minutes in a spa setting.If you choose to try it, only use a reputable, licensed facility that follows strict hygiene rules, and never share water with someone who has a skin infection.

From our Fish Therapy monograph — the full record covers uses, side effects and every documented interaction.

Read the full Fish Therapy monograph & all interactions
Medication

About Psyllium

What Is Psyllium Used For?

Brand name: Metamucil

Psyllium is used to treat occasional constipation and help restore regularity. It is available under many brand names — including Careone, Best Choice, Premier Value Fiber, fiber laxative, meijer fiber laxative, Publix, Best Choice Fiber Therapy, Daily Fiber, Dr. Fibra, Lidl Orange Smooth Fiber Powder, and meijer fiber therapy — all for this same purpose.

Most products note that psyllium generally produces a bowel movement within 12 to 72 hours of taking a dose.

See full Psyllium drug information
Keep checking

Other Drugs & Fish Therapy

Browse every other medication we’ve checked against Fish Therapy — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Fish Therapy against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Fish Therapy list.

See the full Fish Therapy interactions page
See every supplement checked against Psyllium (OTC drug), ranked by severity
Evidence & sources

Fish Therapy References

The 8 references that drive our Fish Therapy monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Grassberger M, Hoch W. Ichthyotherapy as alternative treatment for patients with psoriasis: a pilot study. Evid Based Complement Alternat Med. 2006 Dec;3(4):483-8. PubMed
  2. Lipner SR. Onychomadesis Following a Fish Pedicure. JAMA Dermatol. 2018 Sep 1;154(9):1091-1092. PubMed
  3. Vanhooteghem O, Anseeuw D, Michel C, et al. Fish Pedicure-induced Aeromonas sobria Superficial Necrotic Bullous Dermatitis in a Previously Undiagnosed Diabetes Patient. What are the Risks of Fish Pedicure for Public Health? BJMMR. 2015;10(12):1-10. DOI
  4. Veraldi S, Nazzaro G, Çuka E. Staphylococcus aureus infection of the feet following fish pedicure. Infection. 2014 Oct;42(5):925-6. PubMed
  5. Sugimoto K, Frei R, Graber P. Methicillin-resistant Staphylococcus aureus foot infection after fish pedicure. Infection. 2013 Oct;41(5):1013-5. PubMed
  6. Vanhooteghem O, Theate I. Fish pedicure-induced foot mycobacteriosis infection due to Mycobacterium marinum: a first case report. Eur J Dermatol. 2017 Jun 1;27(3):299-300. PubMed
  7. US Centers for Disease Control (CDC). Fish Pedicures and Fish Spas. August 2, 2016. Available at: https://www.cdc.gov/healthywater/hygiene/body/fish_pedicures.html. Accessed on June 15, 2020.
  8. Vanhooteghem O, Theate I, De Schaetzen V. Periungual Mycobacterium marinum Infection following a Fish Manicure. Skin Appendage Disord. 2021 Aug;7(5):393-396.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Having Fish Therapy While Taking Psyllium (OTC drug): Common Questions

Is it safe to have Fish Therapy while taking Psyllium (OTC drug)?
We do not list a known interaction between Fish Therapy and Psyllium (OTC drug). That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Psyllium (OTC drug) interact with any supplements?
Yes. Psyllium (OTC drug) has documented interactions with 17 supplements in our database — Fish Therapy is not one of them. The Psyllium (OTC drug) interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Fish Therapy monograph Uses, safety profile, and every drug interaction in one place Psyllium drug information The full plain-English guide to this medication Psyllium (OTC drug) supplement interactions Every supplement checked against Psyllium (OTC drug), ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Psyllium (OTC drug) and Fish Therapy?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.