Drug & supplement interaction

Fly Agaric Mushroom + Methotrexate

Methotrexate brand names: Rheumatrex, Otrexup, Rasuvo, Reditrex.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Fly Agaric Mushroom and Methotrexate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Fly Agaric Mushroom and Methotrexate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Methotrexate and Fly Agaric Mushroom in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Fly Agaric Mushroom at all — not against Methotrexate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Fly Agaric Mushroom safety at a glance

Fly Agaric Mushroo... overall Avoid This is a poisonous mushroom with toxic, mind-altering compounds and no proven medical benefit.
Pregnancy Unsafe When used orally due to its toxicity; avoid using. Read the full pregnancy detail
Breastfeeding Unsafe When used orally due to its toxicity; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Methotrexate and Fly Agaric Mushroom? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Fly Agaric Mushroom and Methotrexate May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Seizures Worth acting on Additional detail

    Fly Agaric Mushroom

    “Orally, fly agaric mushroom poisoning is associated with suicide attempts, used as a hallucinogen, or accidental ingestion. The effects of fly agaric mushroom peak at 2-3 hours and can last as long as 5 days. Mind-altering effects have occurred with ingestion of 2-4 mushrooms (18).”

    Fly Agaric Mushroom · Natural Medicines adverse-effect record, reported in epilepsy.

    6 sources cited
    1. 30529. DONALIES, G. and VOELZ, G. [A suicide attempt with fly agaric. On the toxicology of Amanita muscaria. With a contribution to the psychology of the choice of suicide agent.]. Nervenarzt 4-20-1960;31:182-185.
    2. 30530. DONALIES, G. and VOELZ, G. [A suicide attempt with fly agaric II. On the toxicology of Amanita muscaria. With a contribution to the psychology of the choice of suicide agent.]. Nervenarzt 1961;32:552-555.
    3. 96059. Mikaszewska-Sokolewicz MA, Pankowska S, Janiak M, Pruszczyk P, Lazowski T, Jankowski K. Coma in the course of severe poisoning after consumption of red fly agaric (Amanita muscaria). Acta Biochim Pol. 2016;63(1):181-182. PubMed
    4. 112891. Meisel EM, Morgan B, Schwartz M, Kazzi Z, Cetin H, Sahin A. Two cases of severe Amanita muscaria poisoning including a fatality. Wilderness Environ Med 2022;33(4):412-416.
    5. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    6. 116175. Ebbens EF, Williams SR, Bruccoleri RE, Frazier SB. Neurotoxicity associated with the medicinal mushroom product-Diamond Shruumz: A case report. Toxicol Rep 2024;13:101748. PubMed

    Methotrexate

    Listed in the ADVERSE REACTIONS section of the FDA label for Methotrexate. Read the label on DailyMed ›

  • Drowsiness Additional detail

    Fly Agaric Mushroom

    “Orally, fly agaric mushroom is poisonous and can cause significant toxicity. Any benefits of therapy may not outweigh the risk of toxicity. Although accidental fly agaric mushroom poisoning is rare because of its distinctive appearance, heavy rains can wash away the distinctive white plaques, causing the mushroom to be mistaken for a different, edible species of mushroom (Amanita caesarea).

    Most Common Adverse Effect…”

    Fly Agaric Mushroom · Natural Medicines adverse-effect record, reported in cardiac arrest.

    Methotrexate

    Listed in the ADVERSE REACTIONS section of the FDA label for Methotrexate. Read the label on DailyMed ›

  • Stomach pain / Nausea / Diarrhea / Vomiting reported in 5.9% of FDA reports for Methotrexate Additional detail

    Fly Agaric Mushroom

    “Orally, initial symptoms of fly agaric mushroom toxicity usually include nausea, vomiting, diarrhea, and abdominal pain. These often occur within 15-90 minutes of ingestion (18,96059,106533,112891,116175).”

    Fly Agaric Mushroom · Natural Medicines adverse-effect record, reported in diarrhea.

    5 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 96059. Mikaszewska-Sokolewicz MA, Pankowska S, Janiak M, Pruszczyk P, Lazowski T, Jankowski K. Coma in the course of severe poisoning after consumption of red fly agaric (Amanita muscaria). Acta Biochim Pol. 2016;63(1):181-182. PubMed
    3. 106533. Rampolli FI, Kamler P, Carnevale Carlino C, Bedussi F. The Deceptive Mushroom: Accidental Amanita muscaria Poisoning. Eur J Case Rep Intern Med 2021;8(3):002212. PubMed
    4. 112891. Meisel EM, Morgan B, Schwartz M, Kazzi Z, Cetin H, Sahin A. Two cases of severe Amanita muscaria poisoning including a fatality. Wilderness Environ Med 2022;33(4):412-416.
    5. 116175. Ebbens EF, Williams SR, Bruccoleri RE, Frazier SB. Neurotoxicity associated with the medicinal mushroom product-Diamond Shruumz: A case report. Toxicol Rep 2024;13:101748. PubMed

    Methotrexate

    Listed in the ADVERSE REACTIONS section of the FDA label for Methotrexate, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Fly Agaric Mushroom but not commonly for Methotrexate: confusion, hallucinations, anxiety or restlessness and mania or an unusually elevated mood.

Effects for Methotrexate come from the ADVERSE REACTIONS section of its FDA label; effects for Fly Agaric Mushroom come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 489,806 voluntary FDA FAERS reports for Methotrexate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Fly Agaric Mushroom in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When used orally due to its toxicity; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Fly Agaric Mushroom or Methotrexate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Fly Agaric Mushroom or Methotrexate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Methotrexate

This page covers Fly Agaric Mushroom only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methotrexate page lists 82 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Apple (major), Beer (major), Grapefruit (major) and Siberian Cocklebur (major).

By severity: 7 major · 60 moderate · 15 minor.

From our pharmacist’s overview on the Methotrexate page

“The liver is where methotrexate and supplements clash most. Methotrexate (Rheumatrex, Otrexup, Rasuvo), used for rheumatoid arthritis, psoriasis, and certain cancers, can strain the liver on its own, and 38 of the 82 interacting ingredients on this list add liver risk of their own, alcohol included, which makes this a list to approach…”

Reviewed by 2 · Jul 18, 2026

Open the Methotrexate interaction page

How much people look this up

Where Fly Agaric Mushroom and Methotrexate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Fly Agaric Mushroom
Steady interest

#896 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Methotrexate
Top 5%

#49 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Fly Agaric Mushroom reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Fly Agaric Mushroom and Methotrexate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Fly Agaric Mushroom

What is Fly Agaric Mushroom?

  • Relaxation and sleep
  • Pain relief (traditional use)
  • Mood and anxiety
  • Ritual and traditional/folk practices
  • Insect control (historical use as a flykiller)

Fly agaric is a poisonous, psychoactive mushroom that contains nerve-acting toxins, and it is not a proven or safe dietary supplement. Eating it raw or in unprocessed form can cause serious poisoning, and there is no reliable evidence it treats any medical condition. We strongly recommend avoiding it and talking to a doctor or pharmacist about safer options.

Amanita muscaria · Amanitaceae · Cap and fruiting body of the mushroom · Dried caps, powders, capsules, tinctures, teas (sold by some vendors as a 'microdose' product)

An interaction check asks whether these two react with each other — it does not ask whether Fly Agaric Mushroom is a good idea for someone in your situation. Here is what our Fly Agaric Mushroom record says about it on its own.

Fly Agaric Mushroom: dosing

There is no established safe or standardized dose for fly agaric. Because the amount of toxins varies greatly between mushrooms—and because preparation methods are inconsistent—any amount carries a real risk of poisoning.We do not recommend using this mushroom. Products sold online that claim a "safe microdose" are not regulated and have not been proven safe.

From our Fly Agaric Mushroom monograph — the full record covers uses, side effects and every documented interaction.

Read the full Fly Agaric Mushroom monograph & all interactions
Medication

About Methotrexate

What Is Methotrexate Used For?

Brand names: Rheumatrex, Otrexup, Rasuvo, Reditrex

Methotrexate treats a wide range of serious conditions. In cancer care, it is used for acute lymphoblastic leukemia, non-Hodgkin lymphoma, osteosarcoma, breast cancer, head and neck cancer, and gestational trophoblastic neoplasia (a rare tumor related to pregnancy). It is also used to prevent and treat meningeal leukemia (cancer affecting the lining of the brain and spinal cord).

Outside of cancer, methotrexate is prescribed for adults with rheumatoid arthritis (RA), children with polyarticular juvenile idiopathic arthritis (a form of childhood arthritis), and adults with severe psoriasis that hasn't responded well to other treatments.

Most-Reported Side Effects for Methotrexate

From FAERS, the FDA’s public side-effect reporting system (489,806 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Rheumatoid arthritis 42,798 reports
Arthralgia 40,830 reports
Fatigue 33,049 reports
Nausea 28,999 reports
Joint swelling 25,026 reports
See full Methotrexate drug information
Keep checking

Other Drugs & Fly Agaric Mushroom

Browse every other medication we’ve checked against Fly Agaric Mushroom — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Fly Agaric Mushroom against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Fly Agaric Mushroom list.

See the full Fly Agaric Mushroom interactions page
See every supplement checked against Methotrexate, ranked by severity
Evidence & sources

Fly Agaric Mushroom References

The 10 references that drive our Fly Agaric Mushroom monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. DONALIES, G. and VOELZ, G. [A suicide attempt with fly agaric. On the toxicology of Amanita muscaria. With a contribution to the psychology of the choice of suicide agent.]. Nervenarzt 4-20-1960;31:182-185.
  3. DONALIES, G. and VOELZ, G. [A suicide attempt with fly agaric II. On the toxicology of Amanita muscaria. With a contribution to the psychology of the choice of suicide agent.]. Nervenarzt 1961;32:552-555.
  4. ROCH, M. and MACH, J. P. [Severe prolonged delirium caused by Amanita muscaria (fly agaric) poisoning.]. Praxis. 3-3-1960;49:225-227.
  5. Satora, L., Pach, D., Butryn, B., Hydzik, P., and Balicka-Slusarczyk, B. Fly agaric (Amanita muscaria) poisoning, case report and review. Toxicon 6-1-2005;45(7):941-943. PubMed
  6. Mikaszewska-Sokolewicz MA, Pankowska S, Janiak M, Pruszczyk P, Lazowski T, Jankowski K. Coma in the course of severe poisoning after consumption of red fly agaric (Amanita muscaria). Acta Biochim Pol. 2016;63(1):181-182. PubMed
  7. Rampolli FI, Kamler P, Carnevale Carlino C, Bedussi F. The Deceptive Mushroom: Accidental Amanita muscaria Poisoning. Eur J Case Rep Intern Med 2021;8(3):002212. PubMed
  8. Meisel EM, Morgan B, Schwartz M, Kazzi Z, Cetin H, Sahin A. Two cases of severe Amanita muscaria poisoning including a fatality. Wilderness Environ Med 2022;33(4):412-416.
  9. Ebbens EF, Williams SR, Bruccoleri RE, Frazier SB. Neurotoxicity associated with the medicinal mushroom product-Diamond Shruumz: A case report. Toxicol Rep 2024;13:101748. PubMed
  10. Maung AC, Hennessey M, Kadiyala R. Accidental colourful mushroom poisoning - delirium, delusions and dreams. Clin Med (Lond) 2023;23(4):417-419. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Fly Agaric Mushroom and Methotrexate Together: Common Questions

Is it safe to take Fly Agaric Mushroom with Methotrexate?
We do not list a known interaction between Fly Agaric Mushroom and Methotrexate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Fly Agaric Mushroom and Methotrexate have any of the same side effects?
Yes — our sources link each of them separately to 6 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Methotrexate interact with any supplements?
Yes. Methotrexate has documented interactions with 82 supplements in our database — Fly Agaric Mushroom is not one of them. The Methotrexate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Fly Agaric Mushroom monograph Uses, safety profile, and every drug interaction in one place Methotrexate drug information The full plain-English guide to this medication Methotrexate supplement interactions Every supplement checked against Methotrexate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 10 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Methotrexate and Fly Agaric Mushroom?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.