Drug & supplement interaction

Fool's Parsley + Donepezil

Donepezil brand name: Aricept.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Fool's Parsley and Donepezil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Fool's Parsley and Donepezil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Donepezil and Fool's Parsley in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Fool's Parsley at all — not against Donepezil, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Fool's Parsley safety at a glance

Fool's Parsley overall Avoid The raw plant is toxic and easily confused with edible parsley, so it should not be consumed.
Pregnancy Likely Unsafe When used orally due to potential for poisoning. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally due to potential for poisoning. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Donepezil and Fool's Parsley? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Donepezil’s Own FDA Label Lists

This is not an interaction — none of it involves Fool's Parsley. These are the most notable effects listed in the ADVERSE REACTIONS section of Donepezil’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 3 of them are worth acting on rather than waiting out — marked below.

  • Bleeding in the gut Worth acting on
  • Seizures Worth acting on
  • Bleeding or bruising Worth acting on
  • Weight loss
  • Reduced appetite
  • Muscle pain
  • Trouble sleeping
  • Tiredness mentioned in 4.8% of FDA reports for Donepezil
  • Diarrhea mentioned in 5.0% of FDA reports for Donepezil
  • Nausea mentioned in 4.6% of FDA reports for Donepezil

Showing the 10 most notable of 11 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Donepezil. Read the label on DailyMed › Where a percentage is shown, it is the share of 37,026 voluntary FDA FAERS reports for Donepezil that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Fool's Parsley’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Fool's Parsley side to compare — that is a limit of the record, not a statement that Fool's Parsley has no side effects.

Special populations

Fool's Parsley in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally due to potential for poisoning.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Fool's Parsley or Donepezil

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Fool's Parsley or Donepezil, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Donepezil

This page covers Fool's Parsley only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Donepezil page lists 173 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), 1,3-dmaa (moderate) and Acacia Rigidula (moderate).

By severity: 3 major · 127 moderate · 43 minor.

From our pharmacist’s overview on the Donepezil page

“If you or a loved one takes donepezil (Aricept) for Alzheimer's disease, this is a list worth reading with real care, starting with the three major-rated entries: grapefruit, St. John's wort, and activated charcoal.”

Reviewed by 2 · Jul 18, 2026

Open the Donepezil interaction page

How much people look this up

Where Fool's Parsley and Donepezil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Fool's Parsley
Steady interest

#1,197 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Donepezil
Steady interest

#2,145 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Fool's Parsley reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Fool's Parsley and Donepezil records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Fool's Parsley

What is Fool's Parsley?

  • Digestive complaints (traditional/homeopathic)
  • Diarrhea in children (homeopathic tradition)
  • Nausea and vomiting (homeopathic tradition)
  • Restlessness (homeopathic tradition)

Fool's Parsley is a poisonous weed that closely resembles edible parsley and has no proven medicinal benefit. The raw plant is toxic and should never be eaten; the only modern use is in highly diluted homeopathic products, which lack reliable evidence of effectiveness. If you are looking for a culinary herb, do not gather wild plants that resemble parsley.

Aethusa cynapium · Apiaceae · Whole plant (aerial parts), occasionally used in homeopathic preparations · Homeopathic dilutions; rarely as crude plant material (not recommended)

An interaction check asks whether these two react with each other — it does not ask whether Fool's Parsley is a good idea for someone in your situation. Here is what our Fool's Parsley record says about it on its own.

Fool's Parsley: dosing

There is no established safe medicinal dose of Fool's Parsley. The crude plant is poisonous and should not be taken at any amount.For homeopathic products, dosing follows the directions on the specific product label, but these are not standardized medical doses and are not supported by strong evidence.

From our Fool's Parsley monograph — the full record covers uses, side effects and every documented interaction.

Read the full Fool's Parsley monograph & all interactions
Medication

About Donepezil

What Is Donepezil Used For?

Brand name: Aricept

Donepezil is used to treat dementia of the Alzheimer's type. It has been shown to be effective across all stages — mild, moderate, and severe Alzheimer's disease.

It can help with memory, thinking, and daily functioning, though it works differently for each person. Donepezil does not cure Alzheimer's disease or stop the disease from progressing.

Most-Reported Side Effects for Donepezil

From FAERS, the FDA’s public side-effect reporting system (37,026 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fall 3,130 reports
Confusional state 2,010 reports
Dizziness 1,857 reports
Diarrhea 1,840 reports
Fatigue 1,794 reports
See full Donepezil drug information
Keep checking

Other Drugs & Fool's Parsley

Browse every other medication we’ve checked against Fool's Parsley — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Fool's Parsley against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Fool's Parsley list.

See the full Fool's Parsley interactions page
See every supplement checked against Donepezil, ranked by severity
Evidence & sources

Fool's Parsley References

The 1 references that drive our Fool's Parsley monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Fool's Parsley and Donepezil Together: Common Questions

Is it safe to take Fool's Parsley with Donepezil?
We do not list a known interaction between Fool's Parsley and Donepezil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Donepezil interact with any supplements?
Yes. Donepezil has documented interactions with 173 supplements in our database — Fool's Parsley is not one of them. The Donepezil interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Fool's Parsley monograph Uses, safety profile, and every drug interaction in one place Donepezil drug information The full plain-English guide to this medication Donepezil supplement interactions Every supplement checked against Donepezil, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Donepezil and Fool's Parsley?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.