Drug & supplement interaction

Forget-me-not + Acetaminophen, Codeine

Acetaminophen, Codeine brand names: Tylenol w/ Codeine, Tylenol No.3.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Forget-me-not and Acetaminophen, Codeine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Forget-me-not and Acetaminophen, Codeine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Acetaminophen, Codeine and Forget-me-not in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Forget-me-not at all — not against Acetaminophen, Codeine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Forget-me-not safety at a glance

Forget-me-not overall Not established There is very little reliable safety or effectiveness data for medicinal use.
Pregnancy Possibly Unsafe When used orally, due to possible hepatotoxic pyrrolizidine alkaloid content; avoid using. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally, due to possible hepatotoxic pyrrolizidine alkaloid content; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Acetaminophen, Codeine and Forget-me-not? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Forget-me-not and Acetaminophen, Codeine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea / Vomiting Additional detail

    Forget-me-not

    “Orally, exposure to hepatotoxic pyrrolizidine alkaloids (PA) can cause veno-occlusive disease, lung toxicity, and cancer. Symptoms of acute veno-occlusive disease include colicky pains in epigastrium, vomiting and diarrhea, and ascites formation within several days. Enlargement and induration of the liver occurs within a few weeks.”

    Forget-me-not · Natural Medicines adverse-effect record, reported in cancer.

    1 source cited
    1. 12842. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.

    Acetaminophen, Codeine

    Listed in the ADVERSE REACTIONS section of the FDA label for Acetaminophen, Codeine. Read the label on DailyMed ›

Effects for Acetaminophen, Codeine come from the ADVERSE REACTIONS section of its FDA label; effects for Forget-me-not come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 14,002 voluntary FDA FAERS reports for Acetaminophen, Codeine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Forget-me-not in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally, due to possible hepatotoxic pyrrolizidine alkaloid content; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Acetaminophen, Codeine

This page covers Forget-me-not only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Codeine page lists 240 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Gamma-hydroxybutyrate (ghb) (major).

By severity: 9 major · 191 moderate · 40 minor.

From our pharmacist’s overview on the Acetaminophen, Codeine page

“People usually take Tylenol No. 3 (acetaminophen with codeine) for short-term pain, often while still drinking wine with dinner or reaching for an herbal sleep aid.”

Reviewed by 2 · Jul 18, 2026

Open the Acetaminophen, Codeine interaction page

How much people look this up

Where Forget-me-not and Acetaminophen, Codeine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Forget-me-not
Steady interest

#936 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Acetaminophen, Codeine
Top 5%

#58 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Forget-me-not reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Forget-me-not and Acetaminophen, Codeine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Forget-me-not

What is Forget-me-not?

  • Respiratory complaints (cough, bronchitis)
  • Nosebleeds and minor bleeding (traditional)
  • Eye complaints (folk use)
  • Skin and wound care (topical, traditional)
  • General tonic in folk medicine

Forget-me-not (Myosotis) is a small flowering plant used in folk medicine, mostly for coughs and minor ailments, but there is very little scientific research to support any health benefit. Because it belongs to a plant family that can contain potentially liver-harming compounds, and because safety data are lacking, it is best used cautiously, if at all, and avoided in pregnancy and breastfeeding.

Myosotis scorpioides · Boraginaceae · Aerial parts (flowers, leaves, and stems) · Tea, tincture, dried herb, occasionally topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Forget-me-not is a good idea for someone in your situation. Here is what our Forget-me-not record says about it on its own.

Forget-me-not: dosing

There is no established or standardized dose for forget-me-not. It has not been studied enough to know a safe and effective amount.If you choose to use a product that contains it, follow the directions on the label and do not exceed them.

From our Forget-me-not monograph — the full record covers uses, side effects and every documented interaction.

Read the full Forget-me-not monograph & all interactions
Keep checking

Other Drugs & Forget-me-not

Browse every other medication we’ve checked against Forget-me-not — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Forget-me-not against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Forget-me-not list.

See the full Forget-me-not interactions page
See every supplement checked against Acetaminophen, Codeine, ranked by severity
Evidence & sources

Forget-me-not References

The 1 references that drive our Forget-me-not monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Forget-me-not and Acetaminophen, Codeine Together: Common Questions

Is it safe to take Forget-me-not with Acetaminophen, Codeine?
We do not list a known interaction between Forget-me-not and Acetaminophen, Codeine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Forget-me-not and Acetaminophen, Codeine have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Acetaminophen, Codeine interact with any supplements?
Yes. Acetaminophen, Codeine has documented interactions with 240 supplements in our database — Forget-me-not is not one of them. The Acetaminophen, Codeine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Forget-me-not monograph Uses, safety profile, and every drug interaction in one place Acetaminophen, Codeine supplement interactions Every supplement checked against Acetaminophen, Codeine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Acetaminophen, Codeine and Forget-me-not?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.