Drug & supplement interaction

Forget-me-not + Upadacitinib Hemihydrate

Upadacitinib Hemihydrate brand name: Rinvoq.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Forget-me-not and Upadacitinib Hemihydrate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Forget-me-not and Upadacitinib Hemihydrate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Upadacitinib Hemihydrate and Forget-me-not in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Forget-me-not at all — not against Upadacitinib Hemihydrate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Forget-me-not safety at a glance

Forget-me-not overall Not established There is very little reliable safety or effectiveness data for medicinal use.
Pregnancy Possibly Unsafe When used orally, due to possible hepatotoxic pyrrolizidine alkaloid content; avoid using. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally, due to possible hepatotoxic pyrrolizidine alkaloid content; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Upadacitinib Hemihydrate and Forget-me-not? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Forget-me-not Itself Has Been Linked To

This is not an interaction — nothing below involves Upadacitinib Hemihydrate. It is the side-effect record for Forget-me-not on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Forget-me-not, this list is the first place to look.

  • Diarrhea / Vomiting Additional detail

    “Orally, exposure to hepatotoxic pyrrolizidine alkaloids (PA) can cause veno-occlusive disease, lung toxicity, and cancer. Symptoms of acute veno-occlusive disease include colicky pains in epigastrium, vomiting and diarrhea, and ascites formation within several days. Enlargement and induration of the liver occurs within a few weeks.”

    Forget-me-not · Natural Medicines adverse-effect record, reported in cancer.

    1 source cited
    1. 12842. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.

Everything above comes from the Natural Medicines adverse-effect record for Forget-me-not — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Upadacitinib Hemihydrate’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Upadacitinib Hemihydrate column appears here.

Special populations

Forget-me-not in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally, due to possible hepatotoxic pyrrolizidine alkaloid content; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Upadacitinib Hemihydrate

This page covers Forget-me-not only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Upadacitinib Hemihydrate page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Upadacitinib Hemihydrate page

“Grapefruit is the pairing I would want anyone on Rinvoq (upadacitinib) to know about first. The drug is cleared by a liver enzyme called CYP3A4, and grapefruit blocks that enzyme, letting blood levels climb, which matters for a medicine that already dials down the immune system.”

Reviewed by 2 · Jul 18, 2026

Open the Upadacitinib Hemihydrate interaction page

How much people look this up

Where Forget-me-not and Upadacitinib Hemihydrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Forget-me-not
Steady interest

#1,045 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Upadacitinib Hemihydrate
Top 25%

#484 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Forget-me-not reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Forget-me-not and Upadacitinib Hemihydrate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Forget-me-not

What is Forget-me-not?

  • Respiratory complaints (cough, bronchitis)
  • Nosebleeds and minor bleeding (traditional)
  • Eye complaints (folk use)
  • Skin and wound care (topical, traditional)
  • General tonic in folk medicine

Forget-me-not (Myosotis) is a small flowering plant used in folk medicine, mostly for coughs and minor ailments, but there is very little scientific research to support any health benefit. Because it belongs to a plant family that can contain potentially liver-harming compounds, and because safety data are lacking, it is best used cautiously, if at all, and avoided in pregnancy and breastfeeding.

Myosotis scorpioides · Boraginaceae · Aerial parts (flowers, leaves, and stems) · Tea, tincture, dried herb, occasionally topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Forget-me-not is a good idea for someone in your situation. Here is what our Forget-me-not record says about it on its own.

Forget-me-not: dosing

There is no established or standardized dose for forget-me-not. It has not been studied enough to know a safe and effective amount.If you choose to use a product that contains it, follow the directions on the label and do not exceed them.

From our Forget-me-not monograph — the full record covers uses, side effects and every documented interaction.

Read the full Forget-me-not monograph & all interactions
Medication

About Upadacitinib

What Is Upadacitinib Used For?

Brand name: Rinvoq

Upadacitinib is approved for adults and some children with moderate-to-severe inflammatory conditions when other treatments haven't worked well enough. It targets overactive immune signaling that drives these diseases.

Conditions it treats include:

  • Rheumatoid arthritis (RA) — in adults who didn't respond to TNF blocker medications
  • Psoriatic arthritis — in adults and children 2 years and older who didn't respond to TNF blockers
  • Atopic dermatitis (eczema) — in people 12 and older whose disease isn't controlled by other systemic therapies
  • Ulcerative colitis — in adults who didn't respond to TNF blockers or other approved therapies
  • Crohn's disease — in adults who didn't respond to TNF blockers or other approved therapies

See full Upadacitinib drug information
Keep checking

Other Drugs & Forget-me-not

Browse every other medication we’ve checked against Forget-me-not — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Forget-me-not against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Forget-me-not list.

See the full Forget-me-not interactions page
See every supplement checked against Upadacitinib Hemihydrate, ranked by severity
Evidence & sources

Forget-me-not References

The 1 references that drive our Forget-me-not monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Forget-me-not and Upadacitinib Hemihydrate Together: Common Questions

Is it safe to take Forget-me-not with Upadacitinib Hemihydrate?
We do not list a known interaction between Forget-me-not and Upadacitinib Hemihydrate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Upadacitinib Hemihydrate interact with any supplements?
Yes. Upadacitinib Hemihydrate has documented interactions with 138 supplements in our database — Forget-me-not is not one of them. The Upadacitinib Hemihydrate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Forget-me-not monograph Uses, safety profile, and every drug interaction in one place Upadacitinib drug information The full plain-English guide to this medication Upadacitinib Hemihydrate supplement interactions Every supplement checked against Upadacitinib Hemihydrate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Upadacitinib Hemihydrate and Forget-me-not?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.