Drug & supplement interaction

Frankincense + Loteprednol

Loteprednol brand names: Lotemax, Alrex.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Frankincense and Loteprednol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Frankincense and Loteprednol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Loteprednol and Frankincense in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Frankincense at all — not against Loteprednol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Frankincense safety at a glance

Frankincense overall Use caution Generally well tolerated short-term, but quality and dosing vary widely between products.
Pregnancy Avoid Not enough safety information; avoid use during pregnancy.
Breastfeeding Avoid Not enough safety information; avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Loteprednol and Frankincense? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Frankincense and Loteprednol May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Itching Additional detail

    Frankincense

    “Topically and by inhalation, frankincense essential oil seems to be well tolerated. For information on the safety of frankincense when used orally, see the Boswellia serrata monograph.

    Most Common Adverse Effects:

    Topically: Dermatitis, irritation, itching.”

    Frankincense · Natural Medicines adverse-effect record, reported in dermatitis.

    Loteprednol

    Listed in the ADVERSE REACTIONS section of the FDA label for Loteprednol. Read the label on DailyMed ›

Reported for Frankincense but not commonly for Loteprednol: a skin rash.

Effects for Loteprednol come from the ADVERSE REACTIONS section of its FDA label; effects for Frankincense come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

One more smart check

Taking Frankincense as Part of a Dietary Supplement Product? Check It for Interactions

We hold 56 real supplement products containing Frankincense, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Frankincense. Even though Frankincense itself has no known interaction with Loteprednol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Frankincense and Loteprednol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Frankincense
Top half

#380 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Loteprednol
Top half

#746 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Frankincense reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Frankincense and Loteprednol records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Frankincense

What is Frankincense?

Frankincense
  • Joint pain and osteoarthritis
  • Inflammation
  • Digestive complaints
  • Asthma and breathing problems
  • Calming aromatherapy

Frankincense is the aromatic resin of the Boswellia tree and is best known for its boswellic acids, which may help with inflammation and joint pain. Early research is promising for conditions like osteoarthritis, but the evidence is still limited and dosing is not standardized. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Boswellia serrata · Burseraceae · Oleo-gum-resin from the tree bark; essential oil distilled from the resin · Capsules and tablets (often standardized Boswellia extract), resin, essential oil for aromatherapy, topical creams

An interaction check asks whether these two react with each other — it does not ask whether Frankincense is a good idea for someone in your situation. Here is what our Frankincense record says about it on its own.

Frankincense: dosing

There is no official, standardized dose of frankincense. Studies have used different Boswellia extracts standardized to varying amounts of boswellic acids, so it is hard to compare products directly.The safest approach is to follow the directions on the product label and choose a reputable brand that lists its boswellic acid content. Essential oils are for inhalation or diluted topical use only and should never be taken by mouth.

From our Frankincense monograph — the full record covers uses, side effects and every documented interaction.

Read the full Frankincense monograph & all interactions
Medication

About Loteprednol Ophthalmic

What Is Loteprednol Ophthalmic Used For?

Brand names: Lotemax, Alrex

Loteprednol ophthalmic suspension is used to treat steroid-responsive inflammatory conditions of the eye, including allergic conjunctivitis, iritis (inflammation inside the eye), cyclitis, superficial punctate keratitis, herpes zoster keratitis, acne rosacea affecting the eye, and certain types of infectious conjunctivitis — when reducing swelling and inflammation is important enough to accept the risks of steroid use.

Loteprednol ophthalmic suspension is also used to treat inflammation after eye surgery. Eysuvis (loteprednol etabonate ophthalmic suspension) is specifically indicated for short-term use of up to two weeks for these inflammatory conditions.

See full Loteprednol Ophthalmic drug information
Keep checking

Other Drugs & Frankincense

Browse every other medication we’ve checked against Frankincense — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Frankincense against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Frankincense list.

See the full Frankincense interactions page
See every supplement checked against Loteprednol, ranked by severity
Evidence & sources

Frankincense References

The 2 references that drive our Frankincense monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Acebo, E., Raton, J. A., Sautua, S., Eizaguirre, X., Trebol, I., and Perez, J. L. Allergic contact dermatitis from Boswellia serrata extract in a naturopathic cream. Contact Dermatitis 2004;51(2):91-92.
  2. Buonomo M, Hylwa S. Allergic contact dermatitis from Boswellia carterii (frankincense) oil. Contact Dermatitis 2021;85(4):465-467.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Frankincense and Loteprednol Together: Common Questions

Is it safe to take Frankincense with Loteprednol?
We do not list a known interaction between Frankincense and Loteprednol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Frankincense and Loteprednol have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Frankincense monograph Uses, safety profile, and every drug interaction in one place Loteprednol Ophthalmic drug information The full plain-English guide to this medication Loteprednol supplement interactions Every supplement checked against Loteprednol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Loteprednol and Frankincense?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.