Drug & supplement interaction

Frostwort + Telotristat Etiprate

Telotristat Etiprate brand name: Xermelo.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Frostwort and Telotristat Etiprate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Telotristat Etiprate states a food rule worth keeping to.

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Interaction report

Frostwort and Telotristat Etiprate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Telotristat Etiprate and Frostwort in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Frostwort at all — not against Telotristat Etiprate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Frostwort safety at a glance

Frostwort overall Not established There is very little modern safety data on frostwort in humans.
Pregnancy Avoid Safety is not established, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety information exists, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Telotristat Etiprate and Frostwort? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Telotristat Etiprate’s Own FDA Label Lists

This is not an interaction — none of it involves Frostwort. These are the most notable effects listed in the ADVERSE REACTIONS section of Telotristat Etiprate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 3 of them are worth acting on rather than waiting out — marked below.

  • A bowel blockage Worth acting on
  • Low mood Worth acting on
  • A severe allergic reaction Worth acting on
  • Bloating or gas
  • Reduced appetite
  • Fever
  • Constipation
  • Itching
  • Swelling
  • Stomach pain

Showing the 10 most notable of 14 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Telotristat Etiprate. Read the label on DailyMed › Frostwort’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Frostwort side to compare — that is a limit of the record, not a statement that Frostwort has no side effects.

How to take them

Some Telotristat Etiprate Products Have a Food Rule — Frostwort Should Not Break It

At least one FDA label for a product containing Telotristat Etiprate says to take it with food. If you take Frostwort on an empty stomach out of habit, keep them separate — and take Telotristat Etiprate with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Telotristat Etiprate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Administration Take Xermelo with food [see Clinical Pharmacology ( 12.3 ), Clinical Studies ( 14 )] .

From the Dosage and Administration section of the FDA label we read for Telotristat Etiprate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Telotristat Etiprate

This page covers Frostwort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Telotristat Etiprate page lists 36 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Alkanna (moderate), Alpine Ragwort (moderate), Boneset (moderate) and Borage (moderate).

By severity: 1 major · 26 moderate · 9 minor.

From our pharmacist’s overview on the Telotristat Etiprate page

“Telotristat etiprate (Xermelo) works in the gut to calm the severe diarrhea of carcinoid syndrome, and the lone major-rated interaction among its 36 flagged supplements strikes at that point. Activated charcoal can soak up the drug before it reaches the bloodstream, and 17 of the entries, mostly bulking fibers and charcoal products, ca…”

Reviewed by 2 · Jul 18, 2026

Open the Telotristat Etiprate interaction page

How much people look this up

Where Frostwort and Telotristat Etiprate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Frostwort
Steady interest

#1,053 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Telotristat Etiprate
Steady interest

#1,560 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Frostwort is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Frostwort reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Frostwort and Telotristat Etiprate records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Frostwort

What is Frostwort?

  • Sore throat and mouth irritation
  • Diarrhea
  • Skin conditions and ulcers (topical)
  • Scrofula (historical/traditional use)
  • General astringent tonic

Frostwort is a North American wildflower used in traditional and folk herbal medicine, mainly as an astringent for sore throats, diarrhea, and skin problems. There is very little modern scientific research to confirm that it works or to define a safe dose, so it should be used cautiously and only after talking with a healthcare professional.

Helianthemum canadense · Cistaceae · Whole plant (leaves and aerial parts) · Dried herb, tea (infusion), tincture, sometimes topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Frostwort is a good idea for someone in your situation. Here is what our Frostwort record says about it on its own.

Frostwort: dosing

There is no established or standardized dose for frostwort. Traditional use varied widely and was not based on measured, tested amounts.If you choose to use a frostwort product, follow the directions on the product label and do not exceed them.

From our Frostwort monograph — the full record covers uses, side effects and every documented interaction.

Read the full Frostwort monograph & all interactions
Medication

About Telotristat

What Is Telotristat Used For?

Brand name: Xermelo

Xermelo (telotristat) tablets are approved to treat carcinoid syndrome diarrhea in adults. Carcinoid syndrome is a set of symptoms caused by certain tumors — called neuroendocrine tumors — that release excess serotonin into the body, triggering frequent, often severe diarrhea.

Xermelo is used in combination with somatostatin analog (SSA) therapy — a class of injected medications commonly used to control carcinoid syndrome — in patients whose diarrhea is still not adequately controlled by SSA therapy alone.

See full Telotristat drug information
Keep checking

Other Drugs & Frostwort

Browse every other medication we’ve checked against Frostwort — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Frostwort against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Frostwort list.

See the full Frostwort interactions page
See every supplement checked against Telotristat Etiprate, ranked by severity
Evidence & sources

Frostwort References

The 1 sources that drive our Frostwort monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Frostwort is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Using Dietary Supplements Wisely — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Frostwort and Telotristat Etiprate Together: Common Questions

Is it safe to take Frostwort with Telotristat Etiprate?
We do not list a known interaction between Frostwort and Telotristat Etiprate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Frostwort and Telotristat Etiprate at the same time of day?
At least one FDA label for a product containing Telotristat Etiprate says to take it with food. If you take Frostwort on an empty stomach out of habit, keep them separate and take Telotristat Etiprate with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Telotristat Etiprate products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Telotristat Etiprate interact with any supplements?
Yes. Telotristat Etiprate has documented interactions with 36 supplements in our database — Frostwort is not one of them. The Telotristat Etiprate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Frostwort monograph Uses, safety profile, and every drug interaction in one place Telotristat drug information The full plain-English guide to this medication Telotristat Etiprate supplement interactions Every supplement checked against Telotristat Etiprate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Telotristat Etiprate and Frostwort?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.