Drug & supplement interaction

Frostwort + Thioguanine

Thioguanine brand names: Thioguanine, Tabloid.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Frostwort and Thioguanine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Frostwort and Thioguanine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Thioguanine and Frostwort in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Frostwort at all — not against Thioguanine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Frostwort safety at a glance

Frostwort overall Not established There is very little modern safety data on frostwort in humans.
Pregnancy Avoid Safety is not established, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety information exists, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Thioguanine and Frostwort? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Thioguanine’s Own FDA Label Lists

This is not an interaction — none of it involves Frostwort. These are the most notable effects listed in the ADVERSE REACTIONS section of Thioguanine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 4 of them are worth acting on rather than waiting out — marked below.

  • Yellowing of the skin or eyes Worth acting on
  • A low platelet count Worth acting on mentioned in 4.8% of FDA reports for Thioguanine
  • Raised blood pressure Worth acting on
  • Liver problems Worth acting on
  • Weight gain
  • Mouth irritation or sores
  • Reduced appetite
  • Swelling
  • Vomiting mentioned in 4.1% of FDA reports for Thioguanine
  • Nausea

From the ADVERSE REACTIONS section of the FDA label for Thioguanine. Read the label on DailyMed › Where a percentage is shown, it is the share of 2,099 voluntary FDA FAERS reports for Thioguanine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Frostwort’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Frostwort side to compare — that is a limit of the record, not a statement that Frostwort has no side effects.

Everything else you take

See Every Supplement That Interacts With Thioguanine

This page covers Frostwort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Thioguanine page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Thioguanine page

“With thioguanine (Tabloid), a chemotherapy pill used mainly for leukemias, the supplement question is an absorption question. Each interaction here can change how much of a swallowed dose reaches the blood, and with a cancer drug that deserves genuine caution, because a partly absorbed dose can undercut treatment.”

Reviewed by 2 · Jul 18, 2026

Open the Thioguanine interaction page

How much people look this up

Where Frostwort and Thioguanine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Frostwort
Steady interest

#1,256 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Thioguanine
Steady interest

#2,335 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Frostwort is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Frostwort reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Frostwort and Thioguanine records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Frostwort

What is Frostwort?

  • Sore throat and mouth irritation
  • Diarrhea
  • Skin conditions and ulcers (topical)
  • Scrofula (historical/traditional use)
  • General astringent tonic

Frostwort is a North American wildflower used in traditional and folk herbal medicine, mainly as an astringent for sore throats, diarrhea, and skin problems. There is very little modern scientific research to confirm that it works or to define a safe dose, so it should be used cautiously and only after talking with a healthcare professional.

Helianthemum canadense · Cistaceae · Whole plant (leaves and aerial parts) · Dried herb, tea (infusion), tincture, sometimes topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Frostwort is a good idea for someone in your situation. Here is what our Frostwort record says about it on its own.

Frostwort: dosing

There is no established or standardized dose for frostwort. Traditional use varied widely and was not based on measured, tested amounts.If you choose to use a frostwort product, follow the directions on the product label and do not exceed them.

From our Frostwort monograph — the full record covers uses, side effects and every documented interaction.

Read the full Frostwort monograph & all interactions
Medication

About Thioguanine

What Is Thioguanine Used For?

Brand names: Thioguanine, Tabloid

Tabloid brand thioguanine is used for remission induction and remission consolidation in acute nonlymphocytic leukemias. That means getting the leukemia into remission and then helping keep it there.

It is not recommended for maintenance or other long-term continuous treatment because of a high risk of liver toxicity. It is not effective for chronic lymphocytic leukemia, Hodgkin’s lymphoma, multiple myeloma, or solid tumors.

Most-Reported Side Effects for Thioguanine

From FAERS, the FDA’s public side-effect reporting system (2,099 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Febrile neutropenia 486 reports
Haematotoxicity 138 reports
Neutropenia 134 reports
Fever 134 reports
Thrombocytopenia 100 reports
See full Thioguanine drug information
Keep checking

Other Drugs & Frostwort

Browse every other medication we’ve checked against Frostwort — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Frostwort against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Frostwort list.

See the full Frostwort interactions page
See every supplement checked against Thioguanine, ranked by severity
Evidence & sources

Frostwort References

The 1 sources that drive our Frostwort monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Frostwort is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Using Dietary Supplements Wisely — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Frostwort and Thioguanine Together: Common Questions

Is it safe to take Frostwort with Thioguanine?
We do not list a known interaction between Frostwort and Thioguanine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Thioguanine interact with any supplements?
Yes. Thioguanine has documented interactions with 17 supplements in our database — Frostwort is not one of them. The Thioguanine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Frostwort monograph Uses, safety profile, and every drug interaction in one place Thioguanine drug information The full plain-English guide to this medication Thioguanine supplement interactions Every supplement checked against Thioguanine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Thioguanine and Frostwort?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.