Gamma-linolenic Acid (gla) + Quinine
Quinine brand name: Qualaquin.
We found no known interaction between Gamma-linolenic Acid (gla) and Quinine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Quinine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Gamma-linolenic Acid (gla) and Quinine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Quinine and Gamma-linolenic Acid (gla) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Gamma-linolenic Acid (gla) safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Quinine
Interactions in our licensed database are recorded against drug classes, not just single drug names. Quinine is filed under 5 classifications — including cytochrome p450 3a4 (cyp3a4) inhibitors, photosensitizing drugs, cytochrome p450 3a4 (cyp3a4) substrates. Gamma-linolenic Acid (gla) has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Quinine’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Gamma-linolenic Acid (gla) Does Interact With Other Medications
Gamma-linolenic Acid (gla) has 122 moderate known drug interactions in our database — Quinine isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Gamma-linolenic Acid (gla)
We haven’t checked that one against Gamma-linolenic Acid (gla) yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Gamma-linolenic Acid (gla). Pick one to open its full report.
Some Quinine Products Have a Food Rule — Gamma-linolenic Acid (gla) Should Not Break It
At least one FDA label for a product containing Quinine says to take it with food. If you take Gamma-linolenic Acid (gla) on an empty stomach out of habit, keep them separate — and take Quinine with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Quinine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Quinine sulfate capsules should be taken with food to minimize gastric upset [see Clinical Pharmacology (12.3) ] .
From the Dosage and Administration section of the FDA label we read for Quinine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
Questions About Gamma-linolenic Acid (gla) or Quinine
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Gamma-linolenic Acid (gla) or Quinine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Quinine
This page covers Gamma-linolenic Acid (gla) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Quinine page lists 175 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Cinchona (major), Foxglove (major), Grapefruit (major) and Lily-of-the-valley (major).
By severity: 9 major · 125 moderate · 41 minor.
From our pharmacist’s overview on the Quinine page
“Quinine (Qualaquin) earns a genuine pause before you add any supplement, because nine of its 175 interacting ingredients are rated major, and two are as everyday as grapefruit and St. John's wort.”
Reviewed by 2 · Jul 18, 2026
Where Gamma-linolenic Acid (gla) and Quinine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#747 of 1,452 supplements looked up here in the last 7 days
#1,499 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Gamma-linolenic Acid (gla) reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Gamma-linolenic Acid (gla) and Quinine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Gamma-linolenic Acid (gla)
What is Gamma-linolenic Acid (gla)?
- Eczema and dry skin
- Rheumatoid arthritis
- Diabetic nerve pain
- PMS and breast pain
- Menopausal symptoms
Gamma-linolenic acid (GLA) is an omega-6 fatty acid found in oils like evening primrose and borage. It is most studied for skin conditions, joint pain, and nerve pain, but the evidence is mixed and far from conclusive. It is generally well tolerated, but talk with your pharmacist or doctor before starting, especially if you are pregnant, breastfeeding, or take other medicines.
Seed oil (from evening primrose, borage, or black currant seeds) · Capsules, softgels, and oils (evening primrose oil, borage oil, black currant seed oil)
An interaction check asks whether these two react with each other — it does not ask whether Gamma-linolenic Acid (gla) is a good idea for someone in your situation. Here is what our Gamma-linolenic Acid (gla) record says about it on its own.
Gamma-linolenic Acid (gla): dosing
There is no single official or standardized dose of GLA. The amount of GLA varies depending on the source oil, since evening primrose, borage, and black currant seed oils contain different concentrations.Because products differ so much, the best approach is to follow the directions on the product label and choose a reputable brand. A pharmacist can help you compare products and figure out an appropriate amount for your situation.Do not assume more is better.
From our Gamma-linolenic Acid (gla) monograph — the full record covers uses, side effects and every documented interaction.
About Quinine
What Is Quinine Used For?
Brand name: Qualaquin
Quinine sulfate capsules (brands Qualaquin and Quinine Sulfate) are approved to treat uncomplicated Plasmodium falciparum malaria in adults. This includes strains of malaria that have become resistant to chloroquine.
Quinine sulfate capsules are not approved for severe or complicated malaria, for preventing malaria, or for treating or preventing nocturnal leg cramps. Using them for leg cramps carries serious risks that outweigh any potential benefit.
Other Drugs & Gamma-linolenic Acid (gla)
Browse every other medication we’ve checked against Gamma-linolenic Acid (gla) — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
122 interactions
- Diclofenac Sodium ›
- Ibuprofen ›
- Aspirin ›
- Naproxen ›
- Minocycline ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Ketoprofen ›
- Bivalirudin ›
- Warfarin Sodium ›
- Bromfenac Sodium ›
- Dabigatran ›
- Diclofenac Epolamine ›
- Iloprost ›
- Piroxicam ›
- Streptokinase ›
- Ticlopidine ›
- Treprostinil (oral) ›
- Abciximab ›
- Abrocitinib ›
- Acenocoumarol ›
- Acetylsalicylic Acid ›
- Anacaulase-bcdb ›
- Anagrelide ›
- Anisindione ›
- Antithrombin Iii ›
- Apixaban ›
- Argatroban ›
- Betrixaban ›
- Cablivi ›
- Cangrelor ›
- Cilostazol ›
- Clopidogrel ›
- Dalteparin ›
- Danaparoid ›
- Defibrotide Sodium ›
- Diclofenac ›
- Dicumarol ›
- Edoxaban ›
- Effient ›
- Enoxaparin ›
- Eptifibatide ›
- Fish Oil Triglycerides ›
- Fondaparinux ›
- Heparin ›
- Ibrutinib ›
- Ibuprofen Lysine ›
- Icosapent Ethyl (prescription Drug) ›
- Inotersen ›
- Lepirudin ›
- Nadroparin ›
- Naproxen Sodium ›
- Nintedanib Esylate ›
- Nusinersen Sodium ›
- Omega-3 Fatty Acids (prescription Drug) ›
- Pazopanib ›
- Pentoxifylline ›
- Phenprocoumon ›
- Reteplase ›
- Rivaroxaban ›
Showing 60 of 122 moderate interactions — see all 122 on the Gamma-linolenic Acid (gla) page.
No interaction 2,707 drugs checked — show the list
We also checked Gamma-linolenic Acid (gla) against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Abemaciclib ›
- Ivermectin ›
- Testosterone ›
- Sertraline ›
- Acetaminophen ›
- Losartan Potassium ›
- Rosuvastatin ›
- Metoprolol ›
- Escitalopram ›
- Atorvastatin ›
- Isotretinoin ›
- Tirzepatide ›
- Methamphetamine ›
- Amlodipine Besylate ›
- Docusate ›
- Sumatriptan ›
- Valacyclovir ›
- Hydroxyurea ›
- Tadalafil ›
- Prednisone ›
- Metformin ›
- Semaglutide ›
- Amitriptyline ›
- Lisdexamfetamine ›
- Propranolol ›
- Amphetamine ›
- Amoxicillin ›
- Methotrexate ›
- Levothyroxine, Liothyronine ›
- Lisinopril ›
- Bupropion ›
- Fluoxetine ›
- Bendamustine ›
- Azithromycin ›
- Pregabalin ›
- Doxycycline ›
- Dextroamphetamine ›
- Gabapentin ›
- Lamotrigine ›
- Acyclovir ›
- Quetiapine ›
- Clonazepam ›
- Buspirone ›
- Omeprazole ›
- Duloxetine ›
- Letrozole ›
- Citalopram ›
- Acetaminophen, Codeine ›
- Methylene Blue ›
- Ciprofloxacin ›
- Candesartan Cilexetil ›
- Amoxicillin, Clavulanate Potassium ›
- Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine ›
- Acetaminophen, Butalbital, Caffeine ›
- Bisoprolol ›
- Acetaminophen, Caffeine, Codeine ›
- Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide ›
Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Gamma-linolenic Acid (gla) list.
Gamma-linolenic Acid (gla) References
The 5 references that drive our Gamma-linolenic Acid (gla) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Guivernau M, Meza N, Barja P, Roman O. Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production. Prostaglandins Leukot Essent Fatty A PubMed
- Leventhal LJ, Boyce EG, Zurier RB. Treatment of rheumatoid arthritis with gammalinolenic acid. Ann Intern Med 1993;119:867-73. PubMed
- Zurier RB, Rossetti RG, Jacobson EW, et al. Gamma-linolenic acid treatment of rheumatoid arthritis. A randomized, placebo-controlled trial. Arthritis Rheum 1996;39:1808-17. PubMed
- Keen H, Payan J, Allawi J, et al. Treatment of diabetic neuropathy with gamma-linolenic acid. The gamma-Linolenic Acid Multicenter Trial Group. Diabetes Care 1993;16:8-15.
- Kim JH, Oh YW, Kim DH, Seo BH, Suh HS, Choi YS. A randomized, placebo-controlled trial of gamma linolenic acid as an add-on therapy to minocycline for the treatment of rosacea. Ann Dermatol 2020;32(6):466-72. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Gamma-linolenic Acid (gla) and Quinine Together: Common Questions
Is it safe to take Gamma-linolenic Acid (gla) with Quinine?
Do Gamma-linolenic Acid (gla) and Quinine have any of the same side effects?
Should I take Gamma-linolenic Acid (gla) and Quinine at the same time of day?
How was the Gamma-linolenic Acid (gla) and Quinine combination checked?
Does Gamma-linolenic Acid (gla) interact with any other medications?
Does Quinine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.