Drug & supplement interaction

Gamma-linolenic Acid (gla) + Enoxaparin

Enoxaparin brand name: Lovenox.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Gamma-linolenic Acid (gla) has a moderate interaction with Enoxaparin. Theoretically, GLA might increase the risk of bleeding when taken with anticoagulant or antiplatelet rugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Gamma-linolenic Acid (gla) and Enoxaparin

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Enoxaparin

Enoxaparin falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Gamma-linolenic Acid (gla) interacts with.

Theoretically, GLA might increase the risk of bleeding when taken with anticoagulant or antiplatelet rugs.
Animal and human research suggests that GLA reduces platelet aggregation.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: enoxaparin (Lovenox) is already a strong blood thinner that stops your body from forming clots. GLA, the omega-6 oil from evening primrose or borage, may make your platelets a little less sticky, so they don't clump together as easily. Stack that mild effect on top of a real anticoagulant and you could, in theory, tip the scales toward easier bruising or bleeding.

I want to be honest about the strength here: this is a theoretical concern based on how GLA behaves, not solid proof from people taking the two together. Still, signs worth watching would be unusual bruising, nosebleeds, pink or red urine, dark stools, or any bleeding that won't stop. Please don't start or stop either one on your own. Just give your pharmacist or doctor a heads-up so they can keep an eye on you.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Guivernau M, Meza N, Barja P, Roman O. Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production. Prostaglandins Leukot Essent Fatty A PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Gamma-linolenic Acid (gla) Also Interacts With Other Medications

Gamma-linolenic Acid (gla) has 121 moderate known drug interactions in our database — the Enoxaparin one above is one of them. If you take anything else, check it against the full list below.

Moderate 121 No known interaction 2,709 (incl. Enoxaparin)
Taking anything else?

Check Another of Your Medications Against Gamma-linolenic Acid (gla)

Covers the 2,830 medications we’ve checked against Gamma-linolenic Acid (gla). Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Enoxaparin

This page covers Gamma-linolenic Acid (gla) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Enoxaparin page lists 202 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Danshen (major), Piracetam (major), Aconite (moderate), Allspice (moderate) and Aloe (moderate).

By severity: 2 major · 183 moderate · 17 minor.

From our pharmacist’s overview on the Enoxaparin page

“If you are giving yourself enoxaparin (Lovenox) shots after surgery or to treat a clot, read this page with real care. All 202 supplement ingredients on file pull on the same thread, bleeding.”

Reviewed by 2 · Jul 18, 2026

Open the Enoxaparin interaction page

How much people look this up

Where Gamma-linolenic Acid (gla) and Enoxaparin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Gamma-linolenic Acid (gla)
Top half

#722 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Enoxaparin
Steady interest

#2,074 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Gamma-linolenic Acid (gla)

What is Gamma-linolenic Acid (gla)?

  • Eczema and dry skin
  • Rheumatoid arthritis
  • Diabetic nerve pain
  • PMS and breast pain
  • Menopausal symptoms

Gamma-linolenic acid (GLA) is an omega-6 fatty acid found in oils like evening primrose and borage. It is most studied for skin conditions, joint pain, and nerve pain, but the evidence is mixed and far from conclusive. It is generally well tolerated, but talk with your pharmacist or doctor before starting, especially if you are pregnant, breastfeeding, or take other medicines.

Read the full Gamma-linolenic Acid (gla) monograph & all interactions
Medication

About Enoxaparin Injection

What Is Enoxaparin Injection Used For?

Brand name: Lovenox

Enoxaparin injection is used to prevent deep vein thrombosis (DVT) — blood clots in the legs — in people having abdominal surgery, hip replacement surgery, or knee replacement surgery, and in hospitalized patients who are largely immobile due to acute illness. It is also used to treat acute DVT, with or without a pulmonary embolism (a clot in the lungs), both in the hospital and at home.

It is also used alongside aspirin to reduce dangerous complications of unstable angina and non-Q-wave heart attack, and to treat acute STEMI (a severe type of heart attack involving full blockage of a coronary artery) in patients who receive clot-dissolving therapy or undergo a procedure to open the blocked artery (PCI).

See full Enoxaparin Injection drug information
Keep checking

Other Drugs & Gamma-linolenic Acid (gla)

Browse every other medication we’ve checked against Gamma-linolenic Acid (gla) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
121Moderate
0Minor
2,708No known interaction
121 Moderate 2,708 No interaction
Moderate

121 interactions

Showing 60 of 121 moderate interactions — see all 121 on the Gamma-linolenic Acid (gla) page.

No interaction 2,708 drugs checked — show the list

We also checked Gamma-linolenic Acid (gla) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,708 medications checked with no known interaction — see the full Gamma-linolenic Acid (gla) list.

See the full Gamma-linolenic Acid (gla) interactions page
See every supplement checked against Enoxaparin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Gamma-linolenic Acid (gla) monograph › Uses, safety, and every drug interaction in one place Enoxaparin supplement interactions › Every supplement checked against Enoxaparin, ranked by severity Enoxaparin Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Gamma-linolenic Acid (gla) and Enoxaparin Together: Common Questions

Can you take Gamma-linolenic Acid (gla) with Enoxaparin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Gamma-linolenic Acid (gla) and Enoxaparin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Enoxaparin and Gamma-linolenic Acid (gla)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.