Drug & supplement interaction

Gamma-linolenic Acid (gla) + Ticlopidine

Ticlopidine brand names: Ticlid, Ticlopidine.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Gamma-linolenic Acid (gla) has a moderate interaction with Ticlopidine. Theoretically, GLA might increase the risk of bleeding when taken with anticoagulant or antiplatelet rugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Gamma-linolenic Acid (gla) and Ticlopidine

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Ticlopidine

Ticlopidine falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Gamma-linolenic Acid (gla) interacts with.

Theoretically, GLA might increase the risk of bleeding when taken with anticoagulant or antiplatelet rugs.
Animal and human research suggests that GLA reduces platelet aggregation.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version. Ticlopidine is an antiplatelet medicine, meaning it keeps your platelets from clumping together and forming clots. GLA, the omega-6 fatty acid in evening primrose and borage oil, seems to nudge platelets in the same direction, making them a little less sticky. Put them together and you may slightly amp up that blood-thinning effect.

What that could look like in real life: easier bruising, nosebleeds, bleeding gums, or cuts that take longer to stop. I want to be honest though, this concern is theoretical, based mostly on how GLA behaves in lab and early studies, not strong proof of harm in people. Still, since Ticlopidine already carries bleeding risk, it's worth a quick chat with your pharmacist or doctor before adding GLA.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Guivernau M, Meza N, Barja P, Roman O. Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production. Prostaglandins Leukot Essent Fatty A PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Gamma-linolenic Acid (gla) Also Interacts With Other Medications

Gamma-linolenic Acid (gla) has 121 moderate known drug interactions in our database — the Ticlopidine one above is one of them. If you take anything else, check it against the full list below.

Moderate 121 No known interaction 2,709 (incl. Ticlopidine)
Taking anything else?

Check Another of Your Medications Against Gamma-linolenic Acid (gla)

Covers the 2,830 medications we’ve checked against Gamma-linolenic Acid (gla). Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Ticlopidine

This page covers Gamma-linolenic Acid (gla) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ticlopidine page lists 221 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Piracetam (major), Aconite (moderate) and Allspice (moderate).

By severity: 3 major · 193 moderate · 25 minor.

From our pharmacist’s overview on the Ticlopidine page

“Ticlopidine (Ticlid) keeps platelets from clumping to prevent clots, so it already raises bleeding risk on its own, and over 200 of the 221 supplements flagged for it push in that same direction. That stacking effect deserves genuine respect from anyone taking this drug.”

Reviewed by 2 · Jul 18, 2026

Open the Ticlopidine interaction page

How much people look this up

Where Gamma-linolenic Acid (gla) and Ticlopidine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Gamma-linolenic Acid (gla)
Steady interest

#1,346 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ticlopidine
Top half

#1,147 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Gamma-linolenic Acid (gla)

What is Gamma-linolenic Acid (gla)?

  • Eczema and dry skin
  • Rheumatoid arthritis
  • Diabetic nerve pain
  • PMS and breast pain
  • Menopausal symptoms

Gamma-linolenic acid (GLA) is an omega-6 fatty acid found in oils like evening primrose and borage. It is most studied for skin conditions, joint pain, and nerve pain, but the evidence is mixed and far from conclusive. It is generally well tolerated, but talk with your pharmacist or doctor before starting, especially if you are pregnant, breastfeeding, or take other medicines.

Read the full Gamma-linolenic Acid (gla) monograph & all interactions
Medication

About Ticlopidine

What Is Ticlopidine Used For?

Brand names: Ticlid, Ticlopidine

  • Ticlopidine is used to reduce the risk of stroke in people who have had a stroke or have had warning signs of a stroke and who cannot be treated with aspirin. Ticlopidine is also used along with aspirin to prevent blood clots from forming in coronary stents (metal tubes surgically placed in clogged blood vessels to improve blood flow). It works by preventing platelets (a type of blood cell) from collecting and forming clots.

See full Ticlopidine drug information
Keep checking

Other Drugs & Gamma-linolenic Acid (gla)

Browse every other medication we’ve checked against Gamma-linolenic Acid (gla) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
121Moderate
0Minor
2,708No known interaction
121 Moderate 2,708 No interaction
Moderate

121 interactions

Showing 60 of 121 moderate interactions — see all 121 on the Gamma-linolenic Acid (gla) page.

No interaction 2,708 drugs checked — show the list

We also checked Gamma-linolenic Acid (gla) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,708 medications checked with no known interaction — see the full Gamma-linolenic Acid (gla) list.

See the full Gamma-linolenic Acid (gla) interactions page
See every supplement checked against Ticlopidine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Gamma-linolenic Acid (gla) monograph › Uses, safety, and every drug interaction in one place Ticlopidine supplement interactions › Every supplement checked against Ticlopidine, ranked by severity Ticlopidine drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Gamma-linolenic Acid (gla) and Ticlopidine Together: Common Questions

Can you take Gamma-linolenic Acid (gla) with Ticlopidine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Gamma-linolenic Acid (gla) and Ticlopidine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Ticlopidine and Gamma-linolenic Acid (gla)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.