Drug & supplement interaction

German Ipecac + Temozolomide

Temozolomide brand name: Temodar.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between German Ipecac and Temozolomide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Temozolomide states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

German Ipecac and Temozolomide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Temozolomide and German Ipecac in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for German Ipecac at all — not against Temozolomide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

German Ipecac safety at a glance

German Ipecac overall Use caution Ipecac-type preparations can cause forceful vomiting and have a narrow margin of safety.
Pregnancy Possibly Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Temozolomide and German Ipecac? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests German Ipecac and Temozolomide May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Vomiting Additional detail

    German Ipecac

    “Orally, high doses of German ipecac may cause vomiting, apnea, and cardiac arrest. Seed extracts may cause advancing paralysis of the central nervous system (18).”

    German Ipecac · Natural Medicines adverse-effect record, reported in cardiac arrest.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Temozolomide

    Listed in the ADVERSE REACTIONS section of the FDA label for Temozolomide. Read the label on DailyMed ›

Effects for Temozolomide come from the ADVERSE REACTIONS section of its FDA label; effects for German Ipecac come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

German Ipecac in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Temozolomide Products Have a Food Rule — German Ipecac Should Not Break It

At least one FDA label for a product containing Temozolomide says to take it on an empty stomach. Most supplements — German Ipecac included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Temozolomide on its own and move German Ipecac to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Temozolomide products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

To reduce nausea and vomiting, take TEMODAR on an empty stomach or at bedtime and consider antiemetic therapy prior to and following TEMODAR administration.

From the Dosage and Administration section of the FDA label we read for Temozolomide — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About German Ipecac or Temozolomide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers German Ipecac or Temozolomide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Temozolomide

This page covers German Ipecac only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Temozolomide page lists 25 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Acerola (moderate), Alpha-lipoic Acid (moderate), Coenzyme Q10 (moderate) and Coffee Charcoal (moderate).

By severity: 1 major · 14 moderate · 10 minor.

From our pharmacist’s overview on the Temozolomide page

“Temozolomide (Temodar) is an oral chemotherapy pill, usually prescribed for aggressive brain tumors, and stakes that high make me treat this list with real caution. Most of the 25 supplements on file interfere in the gut, where fibers, gums, and charcoals may bind the drug or change how much of it gets absorbed.”

Reviewed by 2 · Jul 18, 2026

Open the Temozolomide interaction page

How much people look this up

Where German Ipecac and Temozolomide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement German Ipecac
Top half

#543 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Temozolomide
Steady interest

#2,696 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every German Ipecac reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The German Ipecac and Temozolomide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About German Ipecac

What is German Ipecac?

  • To cause vomiting (emetic)
  • Loosening chest congestion
  • Nausea (in homeopathic dilutions)
  • Cough and bronchial complaints

"German Ipecac" is an uncommon name, and the source plant is not clearly established, so be very cautious about any product sold under this name. True ipecac is a powerful emetic that is no longer recommended for treating poisoning and can be dangerous if misused. Talk to a pharmacist or doctor before using any product labeled as ipecac.

Root and rhizome · Tincture, syrup, homeopathic preparations, dried root

An interaction check asks whether these two react with each other — it does not ask whether German Ipecac is a good idea for someone in your situation. Here is what our German Ipecac record says about it on its own.

German Ipecac: dosing

There is no established, standardized dose for a product called "German Ipecac," and reliable dosing information for this specific name does not exist. Never increase the dose or repeat it on your own. Keep all such products out of reach of children.

From our German Ipecac monograph — the full record covers uses, side effects and every documented interaction.

Read the full German Ipecac monograph & all interactions
Medication

About Temozolomide

What Is Temozolomide Used For?

Brand name: Temodar

Temozolomide treats two types of aggressive brain tumors in adults: glioblastoma and anaplastic astrocytoma. For newly diagnosed glioblastoma, it is given alongside radiation therapy and then continued as maintenance treatment.

For anaplastic astrocytoma, Temodar (the brand-name injection/capsule product) is approved for adjuvant treatment of newly diagnosed cases as well as refractory cases (tumors that have stopped responding to other treatment). Temozolomide Capsules, USP are approved for newly diagnosed glioblastoma and for refractory anaplastic astrocytoma in patients whose disease progressed on a regimen containing nitrosourea and procarbazine.

Most-Reported Side Effects for Temozolomide

From FAERS, the FDA’s public side-effect reporting system (20,946 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Disease progression 1,887 reports
Thrombocytopenia 1,569 reports
Nausea 1,310 reports
Fatigue 1,037 reports
Neutropenia 1,035 reports
See full Temozolomide drug information
Keep checking

Other Drugs & German Ipecac

Browse every other medication we’ve checked against German Ipecac — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked German Ipecac against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full German Ipecac list.

See the full German Ipecac interactions page
See every supplement checked against Temozolomide, ranked by severity
Evidence & sources

German Ipecac References

The 1 references that drive our German Ipecac monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking German Ipecac and Temozolomide Together: Common Questions

Is it safe to take German Ipecac with Temozolomide?
We do not list a known interaction between German Ipecac and Temozolomide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do German Ipecac and Temozolomide have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take German Ipecac and Temozolomide at the same time of day?
At least one FDA label for a product containing Temozolomide says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Temozolomide on its own and move German Ipecac to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Does Temozolomide interact with any supplements?
Yes. Temozolomide has documented interactions with 25 supplements in our database — German Ipecac is not one of them. The Temozolomide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

German Ipecac monograph Uses, safety profile, and every drug interaction in one place Temozolomide drug information The full plain-English guide to this medication Temozolomide supplement interactions Every supplement checked against Temozolomide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Temozolomide and German Ipecac?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.