Drug & supplement interaction

Glucomannan + Bempedoic Acid

Bempedoic Acid brand name: Nexletol.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Glucomannan has a moderate interaction with Bempedoic Acid. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Glucomannan and Bempedoic Acid

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ORAL DRUGS

Why this applies to Bempedoic Acid

Bempedoic Acid falls under ORAL DRUGS — the group Glucomannan interacts with.

Theoretically, glucomannan may decrease absorption of drugs taken orally.
Due to its viscosity and bulking effects, there is concern that glucomannan can decrease the absorption of oral drugs. A small clinical study in healthy volunteers shows that taking glyburide 2.5 mg plus glucomannan 3.9 grams with breakfast reduces plasma levels of glyburide when compared with breakfast and glyburide alone. In addition, animal research demonstrates this effect on amoxicillin, but shows increased absorption of metronidazole. This mouse model also demonstrates that metronidazole elimination is prolonged, but amoxicillin elimination is enhanced by 38%; glucomannan may also affect the distribution of some drugs. To avoid changes in absorption, take glucomannan 30-60 minutes after taking oral drugs.
Severity Moderate Likelihood Probable Evidence B

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: glucomannan is a thick, soluble fiber that turns into a gel in your stomach. That gel can wrap around pills and slow or reduce how much of them your body actually absorbs. With bempedoic acid (Nexletol), the worry is that taking it too close to your fiber could mean less of the drug gets into your system, which may make it a little less effective at lowering your LDL (bad) cholesterol.

The good news is this is mostly theoretical for bempedoic acid, and easy to manage. A simple fix is to separate them: take your bempedoic acid first, then wait about 30 to 60 minutes before your glucomannan. Bempedoic acid isn't a prodrug, so this is about absorption, not activation. Check the timing with your pharmacist before changing anything.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Shima K, Tanaka A, Ikegami H, et al. Effect of dietary fiber, glucomannan, on absorption of sulfonylurea in man. Horm Metab Res 1983;15:1-3. PubMed
  2. Zhang Y, Aldamarany WAS, Song G, et al. Influence of konjac glucomannan and its derivatives on the oral pharmacokinetics of antimicrobial agent in antibiotics cocktails: Keep vigilant on dietary fiber supplement. Int J Biol Macromol 2023;251:126306. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Glucomannan Also Interacts With Other Medications

Glucomannan has 2,021 moderate known drug interactions in our database — the Bempedoic Acid one above is one of them. If you take anything else, check it against the full list below.

Moderate 2,021 No known interaction 809 (incl. Bempedoic Acid)
Taking anything else?

Check Another of Your Medications Against Glucomannan

Covers the 2,830 medications we’ve checked against Glucomannan. Pick one to open its full report.

From our Q&A

Questions About Glucomannan or Bempedoic Acid

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Glucomannan or Bempedoic Acid, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Bempedoic Acid

This page covers Glucomannan only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bempedoic Acid page lists 21 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), African Wild Potato (moderate), Banderol (moderate), Caffeic Acid (moderate) and Coffee Charcoal (moderate).

By severity: 1 major · 11 moderate · 9 minor.

From our pharmacist’s overview on the Bempedoic Acid page

“Activated charcoal is the ingredient I would rule out entirely on bempedoic acid (Nexletol), a daily tablet for lowering LDL cholesterol. It carries the only major rating of the 21 ingredients on file because it can trap the drug in the gut and shrink the dose your body absorbs.”

Reviewed by 2 · Jul 18, 2026

Open the Bempedoic Acid interaction page

One more smart check

Taking Glucomannan as Part of a Dietary Supplement Product? Check It for Interactions

We hold 467 real supplement products containing Glucomannan, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Glucomannan. Your product may carry other ingredients that interact with Bempedoic Acid too, on top of Glucomannan — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Glucomannan and Bempedoic Acid Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Glucomannan
Top 25%

#264 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Bempedoic Acid
Steady interest

#2,127 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Glucomannan

What is Glucomannan?

Glucomannan
  • Weight loss and appetite control
  • Constipation
  • High cholesterol
  • Blood sugar support
  • Digestive health

Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipation, and modestly lowering cholesterol. It is generally well tolerated when taken with plenty of water, but it must be taken carefully because it can swell and cause choking or blockage if not swallowed properly. Talk with your pharmacist or doctor before starting it, especially if you have a health condition or take medicines.

Read the full Glucomannan monograph & all interactions
Medication

About Bempedoic Acid

What Is Bempedoic Acid Used For?

Brand name: Nexletol

Nexletol (bempedoic acid) is used in adults to reduce the risk of major cardiovascular events — including cardiovascular death, heart attack, stroke, and procedures to open blocked arteries — in people at increased cardiovascular risk who are unable to take recommended statin therapy.

Nexletol is also used alongside diet and exercise to lower LDL cholesterol in adults with high cholesterol (hypercholesterolemia), including a genetic form called heterozygous familial hypercholesterolemia (HeFH). It can be used with other cholesterol-lowering medicines or alone when combining with another therapy isn't possible.

See full Bempedoic Acid drug information
Keep checking

Other Drugs & Glucomannan

Browse every other medication we’ve checked against Glucomannan — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
2,021Moderate
0Minor
808No known interaction
2,021 Moderate 808 No interaction
Moderate

2,021 interactions

Showing 60 of 2,021 moderate interactions — see all 2,021 on the Glucomannan page.

No interaction 808 drugs checked — show the list

We also checked Glucomannan against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 808 medications checked with no known interaction — see the full Glucomannan list.

See the full Glucomannan interactions page
See every supplement checked against Bempedoic Acid, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Glucomannan monograph › Uses, safety, and every drug interaction in one place Bempedoic Acid supplement interactions › Every supplement checked against Bempedoic Acid, ranked by severity Bempedoic Acid drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Glucomannan and Bempedoic Acid Together: Common Questions

Can you take Glucomannan with Bempedoic Acid?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Glucomannan and Bempedoic Acid interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Bempedoic Acid and Glucomannan?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.