Drug & supplement interaction

Glucuronolactone + Empagliflozin, Metformin

Empagliflozin, Metformin brand name: Synjardy.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Glucuronolactone and Empagliflozin, Metformin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Empagliflozin, Metformin states a food rule worth keeping to.

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Interaction report

Glucuronolactone and Empagliflozin, Metformin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Empagliflozin, Metformin and Glucuronolactone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Glucuronolactone at all — not against Empagliflozin, Metformin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Glucuronolactone safety at a glance

Glucuronolactone overall Use caution Generally well tolerated in beverage amounts, but long-term safety and high-dose effects are not well studied.
Pregnancy Avoid Not enough safety data; best avoided, especially since it is often combined with caffeine.
Breastfeeding Avoid No reliable safety information during breastfeeding, so avoidance is the safer choice.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Empagliflozin, Metformin and Glucuronolactone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Empagliflozin, Metformin’s Own FDA Label Lists

This is not an interaction — none of it involves Glucuronolactone. These are the most notable effects listed in the ADVERSE REACTIONS section of Empagliflozin, Metformin’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Dehydration Worth acting on
  • Low blood sugar Worth acting on
  • High blood sugar Worth acting on
  • Fainting Worth acting on
  • Kidney problems Worth acting on
  • A severe allergic reaction Worth acting on
  • Hives Worth acting on
  • Liver problems Worth acting on
  • A higher chance of infection Worth acting on
  • An allergic reaction Worth acting on

Showing the 10 most notable of 23 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Empagliflozin, Metformin. Read the label on DailyMed › Glucuronolactone’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Glucuronolactone side to compare — that is a limit of the record, not a statement that Glucuronolactone has no side effects.

How to take them

Some Empagliflozin, Metformin Products Have a Food Rule — Glucuronolactone Should Not Break It

At least one FDA label for a product containing Empagliflozin, Metformin says to take it with food. If you take Glucuronolactone on an empty stomach out of habit, keep them separate — and take Empagliflozin, Metformin with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Empagliflozin, Metformin products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.2 , 2.3 ) SYNJARDY XR: take orally once daily with a meal in the morning, with gradual dosage escalation to reduce the gastrointestinal adverse reactions due to metformin HCl.

From the Dosage and Administration section of the FDA label we read for Empagliflozin, Metformin — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Empagliflozin, Metformin

This page covers Glucuronolactone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Empagliflozin, Metformin page lists 258 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 218 moderate · 38 minor.

From our pharmacist’s overview on the Empagliflozin, Metformin page

“Severe low blood sugar from Siberian cocklebur is the scariest interaction on file for Synjardy (empagliflozin and metformin), and it has actually happened in people, not just in a lab. It is one of only two major-rated entries among the 258 interacting supplements and herbs here, a list I treat with genuine care.”

Reviewed by 2 · Jul 18, 2026

Open the Empagliflozin, Metformin interaction page

One more smart check

Taking Glucuronolactone as Part of a Dietary Supplement Product? Check It for Interactions

We hold 478 real supplement products containing Glucuronolactone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Glucuronolactone. Even though Glucuronolactone itself has no known interaction with Empagliflozin, Metformin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Glucuronolactone and Empagliflozin, Metformin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Glucuronolactone
Top 25%

#304 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Empagliflozin, Metformin
Steady interest

#1,741 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Glucuronolactone is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Glucuronolactone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Glucuronolactone and Empagliflozin, Metformin records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Glucuronolactone

What is Glucuronolactone?

  • Energy and stamina
  • Mental focus and alertness
  • Reducing fatigue
  • Athletic performance
  • Detoxification support (traditional belief)

Glucuronolactone is a naturally occurring compound that is commonly added to energy drinks and supplements, often alongside caffeine and taurine. There is very little solid human evidence that it provides energy, focus, or other benefits on its own, and most studies tested it only as part of a combined product. It appears reasonably well tolerated at the amounts used in drinks, but its long-term safety and effects in pregnancy and breastfeeding are not well studied.

Not a plant; a manufactured/naturally occurring compound (D-glucuronolactone) · Energy drinks, capsules, powders, pre-workout blends

An interaction check asks whether these two react with each other — it does not ask whether Glucuronolactone is a good idea for someone in your situation. Here is what our Glucuronolactone record says about it on its own.

Glucuronolactone: dosing

There is no officially established or standardized dose of glucuronolactone for any health purpose. In energy drinks it commonly appears in amounts of a few hundred milligrams per serving, often alongside caffeine and taurine.Because a proven effective dose has not been identified, the best advice is to follow the product label and not exceed it.

From our Glucuronolactone monograph — the full record covers uses, side effects and every documented interaction.

Read the full Glucuronolactone monograph & all interactions
Keep checking

Other Drugs & Glucuronolactone

Browse every other medication we’ve checked against Glucuronolactone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Glucuronolactone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Glucuronolactone list.

See the full Glucuronolactone interactions page
See every supplement checked against Empagliflozin, Metformin, ranked by severity
Evidence & sources

Glucuronolactone References

The 2 sources that drive our Glucuronolactone monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Glucuronolactone is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Caffeine and Energy Drinks — NIH National Center for Complementary and Integrative Health Source
  2. Caffeine — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Glucuronolactone and Empagliflozin, Metformin Together: Common Questions

Is it safe to take Glucuronolactone with Empagliflozin, Metformin?
We do not list a known interaction between Glucuronolactone and Empagliflozin, Metformin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Glucuronolactone and Empagliflozin, Metformin at the same time of day?
At least one FDA label for a product containing Empagliflozin, Metformin says to take it with food. If you take Glucuronolactone on an empty stomach out of habit, keep them separate and take Empagliflozin, Metformin with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Empagliflozin, Metformin products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Empagliflozin, Metformin interact with any supplements?
Yes. Empagliflozin, Metformin has documented interactions with 258 supplements in our database — Glucuronolactone is not one of them. The Empagliflozin, Metformin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Glucuronolactone monograph Uses, safety profile, and every drug interaction in one place Empagliflozin, Metformin supplement interactions Every supplement checked against Empagliflozin, Metformin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Empagliflozin, Metformin and Glucuronolactone?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.