Medication interaction hub

What Supplements Interact with Empagliflozin, Metformin?

Empagliflozin, Metformin brand name: Synjardy. Every interaction below applies to the brands too.

258 Interactions 2 Major 218 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Empagliflozin, Metformin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Empagliflozin, Metformin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Severe low blood sugar from Siberian cocklebur is the scariest interaction on file for Synjardy (empagliflozin and metformin), and it has actually happened in people, not just in a lab. It is one of only two major-rated entries among the 258 interacting supplements and herbs here, a list I treat with genuine care. Most of the rest, 218 rated moderate, are ingredients like bitter melon that lower blood glucose on their own and can stack with this diabetes medicine until sugar drops too far.

A smaller group does the opposite. Activated charcoal, the other major entry, binds medicines in the gut and cuts how much you absorb, and some fiber-heavy products can do the same to metformin, so keep them well separated from your dose. A few others raise blood sugar and blunt the drug. The 38 minor entries carry less weight; start with the two majors, then check whatever you already take against the full list.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 218 Minor 38 No known interaction 1,194

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Empagliflozin, Metformin: Top Interactions at a Glance

The Empagliflozin, Metformin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 258 interacting ingredients — plus 1,194 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Empagliflozin, Metformin Combinations Today

The Empagliflozin, Metformin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Alpha-lipoic Acid + Empagliflozin, Metformini

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Chromium + Empagliflozin, Metformini

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.

Read the full interaction Minor Likelihood Possible Vitamin B12 + Empagliflozin, Metformini

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.

Read the full interaction Moderate Likelihood Possible Acai + Empagliflozin, Metformini

Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.

Read the full interaction Minor Likelihood Unlikely Blueberry + Empagliflozin, Metformini

Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible Inositol + Empagliflozin, Metformini

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction
The complete list

Every Supplement Checked Against Empagliflozin, Metformin

All 1,452 ingredients in our database, ranked by severity — 258 with a Empagliflozin, Metformin interaction on file and 1,194 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Empagliflozin, Metformin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Alpha-lipoic Acid with Empagliflozin, Metformin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.

Full Alpha-lipoic Acid + Empagliflozin, Metformin answer

Can you take Chromium with Empagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.

Full Chromium + Empagliflozin, Metformin answer

Can you take Vitamin B12 with Empagliflozin, Metformin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.

Full Vitamin B12 + Empagliflozin, Metformin answer

Can you take Acai with Empagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.

Full Acai + Empagliflozin, Metformin answer

Can you take Blueberry with Empagliflozin, Metformin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Blueberry + Empagliflozin, Metformin answer

Can you take Oregano with Empagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.

Full Oregano + Empagliflozin, Metformin answer

Can you take Oregon Grape with Empagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Oregon Grape + Empagliflozin, Metformin answer

Can you take Padang Cassia with Empagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some clinical research shows that Padang cassia can reduce blood glucose levels in healthy patients and in patients with diabetes or impaire...

Full Padang Cassia + Empagliflozin, Metformin answer

Can you take Parsley with Empagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, parsley might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Parsley + Empagliflozin, Metformin answer

Can you take Pata De Vaca with Empagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that pata de vaca may have hypoglycemic effects.

Full Pata De Vaca + Empagliflozin, Metformin answer

Can you take Phaseolus Vulgaris with Empagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Phaseolus vulgaris might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Phaseolus Vulgaris + Empagliflozin, Metformin answer

Can you take Phellodendron with Empagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron may increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Phellodendron + Empagliflozin, Metformin answer

Can you take Phlorizin with Empagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Phlorizin is a potent, nonselective inhibitor of SGLT1 and SGLT2.

Full Phlorizin + Empagliflozin, Metformin answer

Can you take Picrorhiza with Empagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that an extract of picrorhiza can reduce fasting and non-fasting blood sugar levels.

Full Picrorhiza + Empagliflozin, Metformin answer

Can you take Policosanol with Empagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, policosanol might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.

Full Policosanol + Empagliflozin, Metformin answer

Can you take Purple Nut Sedge with Empagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that purple nut sedge can reduce blood glucose levels.

Full Purple Nut Sedge + Empagliflozin, Metformin answer

Can you take Quassia with Empagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In animals, quassia extract reduced levels of fasting glucose.

Full Quassia + Empagliflozin, Metformin answer

Can you take Quercetin with Empagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of quercetin and antidiabetes drugs might increase the risk of hypoglycemia.

Full Quercetin + Empagliflozin, Metformin answer

Can you take Radish with Empagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, radish might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Radish + Empagliflozin, Metformin answer

Can you take Rauvolfia Vomitoria with Empagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Rauvolfia vomitoria with antidiabetes drugs might increase the risk of hypoglycemia.

Full Rauvolfia Vomitoria + Empagliflozin, Metformin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Empagliflozin, Metformin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Empagliflozin, Metformin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Empagliflozin, Metformin sits in 4 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Empagliflozin, Metformin through this category.

Metformin (Glucophage) 18 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

18 of the supplement ingredients on this page reach Empagliflozin, Metformin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Empagliflozin, Metformin through this category.

Empagliflozin (Jardiance) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Empagliflozin, Metformin through this category.

Related: does Empagliflozin, Metformin deplete any nutrients?

Empagliflozin, Metformin has 4 reported nutrient associations in the research literature — see the Empagliflozin, Metformin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Empagliflozin, Metformin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Empagliflozin, Metformin.

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Pharmacist Counseling Corner

Empagliflozin, Metformin & Supplements: Common Questions

What supplements interact with Empagliflozin, Metformin?
More than you might expect — 258 in total, though they are far from equal: 2 are rated major, 218 moderate, and 38 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, American Ginseng.
Which Empagliflozin, Metformin supplement interactions are the most serious?
The 2 major-rated combinations — led by Siberian Cocklebur and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Empagliflozin, Metformin?
Usually yes — most people on Empagliflozin, Metformin can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Synjardy have the same supplement interactions as Empagliflozin, Metformin?
Yes — Synjardy all contain Empagliflozin, Metformin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Empagliflozin, Metformin deplete any vitamins or nutrients?
It might — Empagliflozin, Metformin has 4 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Empagliflozin, Metformin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Empagliflozin, Metformin and my other medications?
This page covers Empagliflozin, Metformin against supplements and herbal ingredients. Checking Empagliflozin, Metformin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.