Drug & supplement interaction

Goat's Rue + Repotrectinib

Repotrectinib brand name: Augtyro.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Goat's Rue and Repotrectinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Goat's Rue and Repotrectinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Repotrectinib and Goat's Rue in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Goat's Rue safety at a glance

Goat's Rue overall Use caution The fresh plant can be toxic, and well-controlled human safety data on supplements are limited.

Pregnancy Avoid Not enough safety data exists, so it is best avoided during pregnancy.

Breastfeeding Use caution It is traditionally used to support milk supply, but quality and safety vary, so use only with professional guidance.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Repotrectinib and Goat's Rue? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Repotrectinib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Repotrectinib is filed under 5 classifications — including cytochrome p450 3a4 (cyp3a4) inducers, p-glycoprotein substrates, hepatotoxic drugs. Goat's Rue has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Repotrectinib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Goat's Rue Does Interact With Other Medications

Goat's Rue has 122 moderate known drug interactions in our database — Repotrectinib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Repotrectinib)

Taking anything else?

Check Another of Your Medications Against Goat's Rue

Covers the 2,830 medications we’ve checked against Goat's Rue. Pick one to open its full report.

What to actually watch for

What Repotrectinib’s Own FDA Label Lists

This is not an interaction — none of it involves Goat's Rue. These are the most notable effects listed in the ADVERSE REACTIONS section of Repotrectinib’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

Muscle weakness Worth acting on mentioned in 4.3% of FDA reports for Repotrectinib
Loss of vision Worth acting on
Memory problems Worth acting on
Unsteadiness Worth acting on
Hallucinations Worth acting on
Heart failure Worth acting on
Confusion Worth acting on
Anemia Worth acting on
Shortness of breath Worth acting on
Liver problems Worth acting on

Showing the 10 most notable of 32 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Repotrectinib. Read the label on DailyMed › Where a percentage is shown, it is the share of 231 voluntary FDA FAERS reports for Repotrectinib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Goat's Rue’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Goat's Rue side to compare — that is a limit of the record, not a statement that Goat's Rue has no side effects.

Everything else you take

See Every Supplement That Interacts With Repotrectinib

This page covers Goat's Rue only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Repotrectinib page lists 186 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 143 moderate · 37 minor.

From our pharmacist’s overview on the Repotrectinib page

“If you take repotrectinib (Augtyro) for ROS1-positive lung cancer or an NTRK-driven tumor, this list calls for real caution, not a quick skim. Repotrectinib relies on the CYP3A4 enzyme to leave your body, and most of the 186 entries here can push its blood level up or drag it down.”

Reviewed by 2 · Jul 18, 2026

Open the Repotrectinib interaction page

One more smart check

Taking Goat's Rue as Part of a Dietary Supplement Product? Check It for Interactions

We hold 80 real supplement products containing Goat's Rue, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Goat's Rue. Even though Goat's Rue itself has no known interaction with Repotrectinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Goat's Rue and Repotrectinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Goat's Rue

Steady interest

#782 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Repotrectinib

Steady interest

#2,246 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Goat's Rue reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Goat's Rue and Repotrectinib records this page draws on were last updated July 3, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Goat's Rue

What is Goat's Rue?

Boosting breast milk supply
Blood sugar support
Traditional digestive remedy
General tonic

Goat's rue is a traditional herb most often used by nursing parents to try to increase milk supply, and it has a historical link to diabetes research. Solid human evidence for either use is limited, and the plant can be toxic in larger amounts, so use it only under the guidance of a pharmacist or doctor.

Galega officinalis · Fabaceae · Above-ground parts (leaves, flowering tops, and seeds) · Tea, capsules, tincture, dried herb

An interaction check asks whether these two react with each other — it does not ask whether Goat's Rue is a good idea for someone in your situation. Here is what our Goat's Rue record says about it on its own.

Goat's Rue: dosing

There is no well-established, standardized dose for goat's rue. Do not exceed the recommended amount, and choose products from reputable brands.

From our Goat's Rue monograph — the full record covers uses, side effects and every documented interaction.

Read the full Goat's Rue monograph & all interactions

Medication

About Repotrectinib

Most-Reported Side Effects for Repotrectinib

From FAERS, the FDA’s public side-effect reporting system (250 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dizziness 42 reports

Nausea 19 reports

Neuropathy peripheral 17 reports

Fatigue 13 reports

Adverse event 12 reports

Keep checking

Other Drugs & Goat's Rue

Browse every other medication we’ve checked against Goat's Rue — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

122Moderate

0Minor

2,707No known interaction

122 Moderate 2,707 No interaction

Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Goat's Rue page.

No interaction 2,707 drugs checked — show the list

We also checked Goat's Rue against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Goat's Rue list.

See the full Goat's Rue interactions page

See every supplement checked against Repotrectinib, ranked by severity

Evidence & sources

Goat's Rue References

The 6 references that drive our Goat's Rue monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Atanasov AT. Effect of Galega officinalis L. extract on platelet aggregation in rats. J Herbs Spices Med Plants 1995;3:71-6.
Atanasov, A. T. and Spasov, V. Inhibiting effect of desalted extract from Galega officinalis L. on platelet aggregation. Folia Med.(Plovdiv.) 1999;41(1):46-50.
Atanasov, A. T. and Spasov, V. Inhibiting and disaggregating effect of gel-filtered Galega officinalis L. herbal extract on platelet aggregation. J.Ethnopharmacol. 2000;69(3):235-240. PubMed
Atanasov, A. T. and Tchorbanov, B. Anti-platelet fraction from Galega officinalis L. inhibits platelet aggregation. J.Med.Food 2002;5(4):229-234.
Atanasov, A. T. and Tchorbanov, B. J. Antiplatelet aggregation activity of a fraction isolated from Galega officinalis L. J Herbs Spices Medicinal Plant 2002;10(2):63-71.
Salatino S, Giacomelli L, Carnevali I, Giacomelli E. The role of natural galactagogues during breast feeding: focus on a Galega officinalis based food supplement. Minerva Pediatr. 2017 Dec;69(6):531-537. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Goat's Rue and Repotrectinib Together: Common Questions

Is it safe to take Goat's Rue with Repotrectinib?

We do not list a known interaction between Goat's Rue and Repotrectinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Goat's Rue and Repotrectinib combination checked?

Interactions in our licensed database are recorded against drug classes. Repotrectinib is filed under 5 classifications, and Goat's Rue has documented interactions with 1 drug class — none of Repotrectinib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Goat's Rue interact with any other medications?

Yes. Goat's Rue has 122 documented drug interactions in our database — Repotrectinib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Repotrectinib interact with any supplements?

Yes. Repotrectinib has documented interactions with 186 supplements in our database — Goat's Rue is not one of them. The Repotrectinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Goat's Rue monograph Uses, safety profile, and every drug interaction in one place Repotrectinib supplement interactions Every supplement checked against Repotrectinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Repotrectinib and Goat's Rue?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.