Drug & supplement interaction

Greater Burnet + Isotretinoin

Isotretinoin brand names: Accutane, Amnesteem, Claravis, Sotret, Absorica, and others.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Greater Burnet and Isotretinoin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Greater Burnet and Isotretinoin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Isotretinoin and Greater Burnet in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Greater Burnet at all — not against Isotretinoin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Greater Burnet safety at a glance

Greater Burnet overall Use caution Generally used traditionally, but human safety data are limited and its high tannin content can cause stomach upset.
Pregnancy Avoid Not enough safety information; best avoided during pregnancy.
Breastfeeding Avoid No reliable safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Isotretinoin and Greater Burnet? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Isotretinoin’s Own FDA Label Lists

This is not an interaction — none of it involves Greater Burnet. These are the most notable effects listed in the ADVERSE REACTIONS section of Isotretinoin’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Thoughts of self-harm Worth acting on mentioned in 4.5% of FDA reports for Isotretinoin
  • Low mood Worth acting on mentioned in 12.1% of FDA reports for Isotretinoin
  • Bone thinning Worth acting on
  • Severe muscle breakdown Worth acting on
  • Hallucinations Worth acting on
  • Pancreatitis Worth acting on
  • Fainting Worth acting on
  • Wheezing Worth acting on
  • A severe skin reaction Worth acting on
  • Seizures Worth acting on

Showing the 10 most notable of 56 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Isotretinoin. Read the label on DailyMed › Where a percentage is shown, it is the share of 46,523 voluntary FDA FAERS reports for Isotretinoin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Greater Burnet’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Greater Burnet side to compare — that is a limit of the record, not a statement that Greater Burnet has no side effects.

From our Q&A

Questions About Greater Burnet or Isotretinoin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Greater Burnet or Isotretinoin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Isotretinoin

This page covers Greater Burnet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Isotretinoin page lists 49 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Vitamin A (major), African Wild Potato (moderate), Alfalfa (moderate) and Angelica Archangelica (moderate).

By severity: 2 major · 35 moderate · 12 minor.

From our pharmacist’s overview on the Isotretinoin page

“Vitamin A is the first thing anyone on isotretinoin (Accutane, Absorica, Claravis) should check their supplements for, because isotretinoin is itself a vitamin A derivative and stacking more on top can push levels into toxic range. It is one of two major-rated entries among the 49 supplements and herbs known to interact with this acne…”

Reviewed by 2 · Jul 18, 2026

Open the Isotretinoin interaction page

How much people look this up

Where Greater Burnet and Isotretinoin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Greater Burnet
Steady interest

#1,107 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Isotretinoin
Top 5%

#45 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Greater Burnet is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Greater Burnet reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Greater Burnet and Isotretinoin records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Greater Burnet

What is Greater Burnet?

  • Diarrhea and digestive upset
  • Minor bleeding and wounds
  • Burns and skin irritation (topical)
  • Sore throat and mouth inflammation
  • Hemorrhoids

Greater Burnet (Sanguisorba officinalis) is a traditional herb whose tannin-rich root has long been used for diarrhea, minor bleeding, and skin problems. Modern human evidence for these uses is very limited, so it should not replace proven treatments. Talk with your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or taking other medicines.

Sanguisorba officinalis · Rosaceae · Root and rhizome (sometimes the leaves and aerial parts) · Dried root, tea/decoction, tincture, powder, topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Greater Burnet is a good idea for someone in your situation. Here is what our Greater Burnet record says about it on its own.

Greater Burnet: dosing

There is no well-established standardized dose for Greater Burnet. Traditional use varies widely depending on the form (tea, tincture, powder, or topical) and the part of the plant.Because reliable dosing studies are lacking, the safest approach is to follow the directions on the product label and not exceed the recommended amount. They can help you decide whether it is appropriate and what amount, if any, is reasonable.

From our Greater Burnet monograph — the full record covers uses, side effects and every documented interaction.

Read the full Greater Burnet monograph & all interactions
Medication

About Isotretinoin

What Is Isotretinoin Used For?

Brand names: Accutane, Amnesteem, Claravis, Sotret, Absorica, Roaccutane

Isotretinoin capsules — sold under brand names including Absorica, Absorica LD, Accutane, Amnesteem, Claravis, and others — are indicated for the treatment of severe recalcitrant nodular acne in non-pregnant patients 12 years of age and older. This means deep, inflamed acne nodules (5 mm or larger) that have not cleared with conventional treatments, including systemic antibiotics.

This medication is reserved for the most severe cases because of its significant potential side effects. It is not used for mild or moderate acne. Absorica and Absorica LD are two distinct products that are not interchangeable with each other on a milligram-per-milligram basis due to differences in bioavailability and recommended dosing.

Most-Reported Side Effects for Isotretinoin

From FAERS, the FDA’s public side-effect reporting system (46,523 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Depression 5,609 reports
Inflammatory bowel disease 5,250 reports
Colitis ulcerative 3,800 reports
Dry skin 2,326 reports
Pregnancy 2,080 reports
See full Isotretinoin drug information
Keep checking

Other Drugs & Greater Burnet

Browse every other medication we’ve checked against Greater Burnet — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Greater Burnet against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Greater Burnet list.

See the full Greater Burnet interactions page
See every supplement checked against Isotretinoin, ranked by severity
Evidence & sources

Greater Burnet References

The 2 sources that drive our Greater Burnet monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Greater Burnet is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Herbs and Supplements — MedlinePlus Source
  2. About Herbs, Botanicals & Other Products — Memorial Sloan Kettering Cancer Center Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Greater Burnet and Isotretinoin Together: Common Questions

Is it safe to take Greater Burnet with Isotretinoin?
We do not list a known interaction between Greater Burnet and Isotretinoin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Isotretinoin interact with any supplements?
Yes. Isotretinoin has documented interactions with 49 supplements in our database — Greater Burnet is not one of them. The Isotretinoin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Greater Burnet monograph Uses, safety profile, and every drug interaction in one place Isotretinoin drug information The full plain-English guide to this medication Isotretinoin supplement interactions Every supplement checked against Isotretinoin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Isotretinoin and Greater Burnet?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.