Greater Burnet + Metoprolol
Metoprolol brand names: Lopressor, Toprol XL.
We found no known interaction between Greater Burnet and Metoprolol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Metoprolol states a food rule worth keeping to.
Greater Burnet and Metoprolol
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Metoprolol and Greater Burnet in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Greater Burnet at all — not against Metoprolol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Greater Burnet safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Metoprolol Products Have a Food Rule — Greater Burnet Should Not Break It
At least one FDA label for a product containing Metoprolol says to take it with food. If you take Greater Burnet on an empty stomach out of habit, keep them separate — and take Metoprolol with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Metoprolol products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Administer once daily with food or after a meal.
From the Dosage and Administration section of the FDA label we read for Metoprolol — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
Questions About Greater Burnet or Metoprolol
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Greater Burnet or Metoprolol, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Does MCT Oil Interact With Amlodipine or Metoprolol? ›
- Concerns Taking Metoprolol With Saw Palmetto ›
- Concerns With Taking Both Metoprolol and Propafenone ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Metoprolol
This page covers Greater Burnet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Metoprolol page lists 183 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Indian Snakeroot (major) and Tyramine (major).
By severity: 5 major · 152 moderate · 26 minor.
From our pharmacist’s overview on the Metoprolol page
“With metoprolol (Lopressor, Toprol XL), a beta-blocker for high blood pressure and heart problems, these interactions deserve genuine care, starting with the five rated major. Most entries pull blood pressure one way or the other: many supplements add to metoprolol's lowering effect and can drop pressure too far, while a few, tyramine…”
Reviewed by 2 · Jul 18, 2026
Where Greater Burnet and Metoprolol Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,021 of 1,452 supplements looked up here in the last 7 days
#7 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Greater Burnet is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Greater Burnet reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Greater Burnet and Metoprolol records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Greater Burnet
What is Greater Burnet?
- Diarrhea and digestive upset
- Minor bleeding and wounds
- Burns and skin irritation (topical)
- Sore throat and mouth inflammation
- Hemorrhoids
Greater Burnet (Sanguisorba officinalis) is a traditional herb whose tannin-rich root has long been used for diarrhea, minor bleeding, and skin problems. Modern human evidence for these uses is very limited, so it should not replace proven treatments. Talk with your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or taking other medicines.
Sanguisorba officinalis · Rosaceae · Root and rhizome (sometimes the leaves and aerial parts) · Dried root, tea/decoction, tincture, powder, topical preparations
An interaction check asks whether these two react with each other — it does not ask whether Greater Burnet is a good idea for someone in your situation. Here is what our Greater Burnet record says about it on its own.
Greater Burnet: dosing
There is no well-established standardized dose for Greater Burnet. Traditional use varies widely depending on the form (tea, tincture, powder, or topical) and the part of the plant.Because reliable dosing studies are lacking, the safest approach is to follow the directions on the product label and not exceed the recommended amount. They can help you decide whether it is appropriate and what amount, if any, is reasonable.
From our Greater Burnet monograph — the full record covers uses, side effects and every documented interaction.
About Metoprolol
What Is Metoprolol Used For?
Brand names: Lopressor, Toprol XL
Metoprolol is used to treat several heart and blood pressure conditions. Metoprolol succinate extended-release tablets (including Toprol-XL) are approved for high blood pressure, angina pectoris (chest pain from the heart), and heart failure. Metoprolol tartrate tablets (including Lopressor) are approved for high blood pressure, angina, and — when used alongside intravenous metoprolol — to reduce the risk of cardiovascular death after a definite or suspected heart attack.
Metoprolol tartrate injection (intravenous form) is used in hemodynamically stable patients with a definite or suspected acute heart attack to reduce cardiovascular death, and is followed by oral metoprolol therapy. Lowering blood pressure with metoprolol reduces the risk of strokes and heart attacks.
Most-Reported Side Effects for Metoprolol
From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Greater Burnet
Browse every other medication we’ve checked against Greater Burnet — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Greater Burnet against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Atorvastatin ›
- Valacyclovir ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Ibuprofen ›
- Methamphetamine ›
- Semaglutide ›
- Sumatriptan ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Bupropion ›
- Metformin ›
- Acyclovir ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Methotrexate ›
- Fluoxetine ›
- Gabapentin ›
- Pregabalin ›
- Amphetamine ›
- Acetaminophen, Codeine ›
- Isotretinoin ›
- Azithromycin ›
- Dextroamphetamine ›
- Clonazepam ›
- Omeprazole ›
- Quetiapine ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Greater Burnet list.
Greater Burnet References
The 2 sources that drive our Greater Burnet monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Greater Burnet is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Herbs and Supplements — MedlinePlus Source
- About Herbs, Botanicals & Other Products — Memorial Sloan Kettering Cancer Center Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Metoprolol Is Linked to Lower Levels of One Nutrient
Natural Medicines records Metoprolol as a medicine that can lower these. This is not an interaction with Greater Burnet — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Metoprolol nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Greater Burnet and Metoprolol Together: Common Questions
Is it safe to take Greater Burnet with Metoprolol?
Should I take Greater Burnet and Metoprolol at the same time of day?
Does Metoprolol interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Metoprolol and Greater Burnet?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.