Drug & supplement interaction

Ground Ivy + Interferon Beta-1a

Interferon Beta-1a brand names: Rebif, Avonex.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Ground Ivy and Interferon Beta-1a in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Ground Ivy and Interferon Beta-1a

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Interferon Beta-1a and Ground Ivy in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Ground Ivy at all — not against Interferon Beta-1a, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ground Ivy safety at a glance

Ground Ivy overall Use caution Limited safety data exist, and high doses or essential oil may be harmful.
Pregnancy Likely Unsafe When used orally because of abortifacient activity; avoid using. Read the full pregnancy detail
Breastfeeding Avoid There is not enough safety information, so it is best avoided while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Interferon Beta-1a and Ground Ivy? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Ground Ivy Itself Has Been Linked To

This is not an interaction — nothing below involves Interferon Beta-1a. It is the side-effect record for Ground Ivy on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Ground Ivy, this list is the first place to look.

  • Itching Additional detail

    “Orally and topically, ground ivy seems to be well tolerated. However, a thorough evaluation of safety outcomes has not been conducted.

    Topically: Itching and stinging.”

    Ground Ivy · Natural Medicines adverse-effect record, reported in pruritus.

    “Skin stinging and itching has been reported in patients applying a ground ivy extract 1% lotion twice daily. This occurred during the first two weeks of treatment, but disappeared upon further treatment.”

    Ground Ivy · Natural Medicines adverse-effect record, reported in pruritus.

    1 source cited
    1. 95014. Ha JH, Kang WH, Lee JO, et al. Clinical evaluation of the depigmenting effect of Glechoma Hederacea extract by topical treatment for 8 weeks on UV-induced pigmentation in Asian skin. Eur J Dermatol. 2011;21(2):218-22. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Ground Ivy — expand a row for the licensed statement it rests on. We haven’t matched Interferon Beta-1a to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Interferon Beta-1a.

Special populations

Ground Ivy in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally because of abortifacient activity; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Interferon Beta-1a

This page covers Ground Ivy only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Interferon Beta-1a page lists 57 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Beer (major), Siberian Cocklebur (major), Wine (major), Alfalfa (moderate) and Angelica Archangelica (moderate).

By severity: 3 major · 53 moderate · 1 minor.

From our pharmacist’s overview on the Interferon Beta-1a page

“Siberian cocklebur, an herb tied to documented cases of liver failure, is the first name to know for anyone injecting interferon beta-1a (Rebif, Avonex) for multiple sclerosis. Interferon beta-1a can strain the liver on its own, which is why prescribers order routine liver blood tests, and 38 of the 57 supplements on file carry that sa…”

Reviewed by 2 · Jul 18, 2026

Open the Interferon Beta-1a interaction page

One more smart check

Taking Ground Ivy as Part of a Dietary Supplement Product? Check It for Interactions

We hold 11 real supplement products containing Ground Ivy, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ground Ivy. Even though Ground Ivy itself has no known interaction with Interferon Beta-1a, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ground Ivy and Interferon Beta-1a Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ground Ivy
Steady interest

#1,204 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Interferon Beta-1a
Steady interest

#2,067 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ground Ivy reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Ground Ivy and Interferon Beta-1a records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ground Ivy

What is Ground Ivy?

Ground Ivy
  • Coughs and upper respiratory complaints
  • Digestive upset
  • Kidney and bladder complaints
  • Mild inflammation or arthritis
  • Menstrual irregularities

Ground ivy is a creeping plant in the mint family that has a long history of folk use for coughs, digestive problems, and urinary complaints. Modern human studies are lacking, so its benefits are unproven. Because of safety concerns, it should be avoided during pregnancy and breastfeeding and used cautiously by everyone else.

Glechoma hederacea · Lamiaceae · Above-ground parts (leaves, flowers, and stems) · Tea, tincture, dried herb, capsules, and occasionally fresh herb

An interaction check asks whether these two react with each other — it does not ask whether Ground Ivy is a good idea for someone in your situation. Here is what our Ground Ivy record says about it on its own.

Ground Ivy: dosing

There is no well-established or standardized dose for ground ivy. Traditional use most often involved a tea made from the dried leaves and flowering tops, or a tincture.Because product strength varies widely and reliable dosing studies are lacking, the safest approach is to follow the directions on a specific product's label and to start low.

From our Ground Ivy monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ground Ivy monograph & all interactions
Medication

About Interferon Beta-1a Intramuscular Injection

What Is Interferon Beta-1a Intramuscular Injection Used For?

Brand names: Rebif, Avonex

  • Interferon beta-1a intramuscular injection is used to treat adults with various forms of multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control) including:

    • clinically isolated syndrome (CIS; nerve symptom episodes that last at least 24 hours),

    • relapsing-remitting forms (course of disease where symptoms flare up from time to time), or

    • secondary progressive forms (course of disease where relapses occur more often).

  • Interferon beta-1a is in a class of medications called immunomodulators. It works by decreasing inflammation and preventing nerve damage that may cause symptoms of multiple sclerosis.

Most-Reported Side Effects for Interferon Beta-1a

From FAERS, the FDA’s public side-effect reporting system (192,069 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Multiple sclerosis relapse 15,851 reports
Influenza like illness 13,253 reports
Fatigue 11,554 reports
Fall 10,604 reports
Multiple sclerosis 9,358 reports
See full Interferon Beta-1a Intramuscular Injection drug information
Keep checking

Other Drugs & Ground Ivy

Browse every other medication we’ve checked against Ground Ivy — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Ground Ivy against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Ground Ivy list.

See the full Ground Ivy interactions page
See every supplement checked against Interferon Beta-1a, ranked by severity
Evidence & sources

Ground Ivy References

The 2 references that drive our Ground Ivy monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Ha JH, Kang WH, Lee JO, et al. Clinical evaluation of the depigmenting effect of Glechoma Hederacea extract by topical treatment for 8 weeks on UV-induced pigmentation in Asian skin. Eur J Dermatol. 2011;21(2):218-22. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ground Ivy and Interferon Beta-1a Together: Common Questions

Is it safe to take Ground Ivy with Interferon Beta-1a?
We do not list a known interaction between Ground Ivy and Interferon Beta-1a. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Interferon Beta-1a interact with any supplements?
Yes. Interferon Beta-1a has documented interactions with 57 supplements in our database — Ground Ivy is not one of them. The Interferon Beta-1a interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ground Ivy monograph Uses, safety profile, and every drug interaction in one place Interferon Beta-1a Intramuscular Injection drug information The full plain-English guide to this medication Interferon Beta-1a supplement interactions Every supplement checked against Interferon Beta-1a, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Interferon Beta-1a and Ground Ivy?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.