Drug & supplement interaction

Hemlock Water Dropwort + Naloxegol

Naloxegol brand name: Movantik.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Hemlock Water Dropwort and Naloxegol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Naloxegol states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Hemlock Water Dropwort and Naloxegol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Naloxegol and Hemlock Water Dropwort in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Hemlock Water Dropwort at all — not against Naloxegol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hemlock Water Dropwort safety at a glance

Hemlock Water Drop... overall Avoid This plant is highly poisonous and can be fatal if eaten.
Pregnancy Unsafe When used orally. Ingestion can be lethal. Read the full pregnancy detail
Breastfeeding Unsafe When used orally. Ingestion can be lethal. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Naloxegol and Hemlock Water Dropwort? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Hemlock Water Dropwort and Naloxegol May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach pain / Nausea / Vomiting reported in 12.5% of FDA reports for Naloxegol Additional detail

    Hemlock Water Dropwort

    “Orally, hemlock water dropwort root can cause nausea, dizziness,, abdominal pain, vomiting, sweating, salivation, weakness, confusion, slurred speech, muscle spasms, tonic-clonic movements, glycosuria, hematuria, hyperventilation, cyanosis, exhaustion, seizures, metabolic acidosis, generalized convulsions, unconsciousness, dilated pupils, cardiac arrest , respiratory depression, and death.”

    Hemlock Water Dropwort · Natural Medicines adverse-effect record, reported in cardiac arrest.

    4 sources cited
    1. 6334. Mitchell MI, Routledge PA. Hemlock water dropwort poisoning-a review. Clin Toxicol 1978;12:417-26. PubMed
    2. 6335. Ball MJ, Flather ML, Forfar JC. Hemlock water dropwort poisoning. Postgrad Med J 1987;63:363-5. PubMed
    3. 6332. Fitzgerald P, Moss N, O'Mahony S, Whelton MJ. Accidental hemlock poisoning. Br Med J (Clin Res Ed) 1987;295:1657. PubMed
    4. 103905. Henry FJ, Cadiet J, Javaudin F, Rozec B. Oenantha Crocata: A Case Report of Multiple Poisoning with Fatal Outcome. J Emerg Med. 2020;59(1):e9-e11. PubMed

    “Orally, hemlock water dropwort root can cause nausea, salivation, abdominal pain, and vomiting.”

    Hemlock Water Dropwort · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    4 sources cited
    1. 6334. Mitchell MI, Routledge PA. Hemlock water dropwort poisoning-a review. Clin Toxicol 1978;12:417-26. PubMed
    2. 6335. Ball MJ, Flather ML, Forfar JC. Hemlock water dropwort poisoning. Postgrad Med J 1987;63:363-5. PubMed
    3. 6332. Fitzgerald P, Moss N, O'Mahony S, Whelton MJ. Accidental hemlock poisoning. Br Med J (Clin Res Ed) 1987;295:1657. PubMed
    4. 103905. Henry FJ, Cadiet J, Javaudin F, Rozec B. Oenantha Crocata: A Case Report of Multiple Poisoning with Fatal Outcome. J Emerg Med. 2020;59(1):e9-e11. PubMed

    Naloxegol

    Listed in the ADVERSE REACTIONS section of the FDA label for Naloxegol, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Sweating Additional detail

    Hemlock Water Dropwort

    Recorded for Hemlock Water Dropwort in the same Natural Medicines adverse-effect record shown under Stomach pain / Nausea / Vomiting above.

    Naloxegol

    Listed in the ADVERSE REACTIONS section of the FDA label for Naloxegol. Read the label on DailyMed ›

Reported for Hemlock Water Dropwort but not commonly for Naloxegol: muscle pain, seizures, dizziness and confusion.

Effects for Naloxegol come from the ADVERSE REACTIONS section of its FDA label; effects for Hemlock Water Dropwort come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 3,902 voluntary FDA FAERS reports for Naloxegol that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Hemlock Water Dropwort in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When used orally. Ingestion can be lethal.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Naloxegol Products Have a Food Rule — Hemlock Water Dropwort Should Not Break It

At least one FDA label for a product containing Naloxegol says to take it on an empty stomach. Most supplements — Hemlock Water Dropwort included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Naloxegol on its own and move Hemlock Water Dropwort to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Naloxegol products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

(2.1) Take on an empty stomach at least 1 hour prior to the first meal of the day or 2 hours after the meal.

From the Dosage and Administration section of the FDA label we read for Naloxegol — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Naloxegol

This page covers Hemlock Water Dropwort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Naloxegol page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Naloxegol page

“Naloxegol (Movantik) relieves the constipation that opioids cause, and this is a list that deserves real care before you add anything from it. Nearly all of the trouble traces to a single enzyme, CYP3A4, which the body relies on to clear naloxegol.”

Reviewed by 2 · Jul 18, 2026

Open the Naloxegol interaction page

One more smart check

Taking Hemlock Water Dropwort as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Hemlock Water Dropwort, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Hemlock Water Dropwort. Even though Hemlock Water Dropwort itself has no known interaction with Naloxegol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Hemlock Water Dropwort and Naloxegol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hemlock Water Dropwort
Steady interest

#1,088 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Naloxegol
Top half

#745 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hemlock Water Dropwort reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Hemlock Water Dropwort and Naloxegol records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Hemlock Water Dropwort

What is Hemlock Water Dropwort?

  • Historical/folk wound poultices (unsafe)
  • Traditional topical use (unsafe)
  • Subject of toxicology research

Hemlock water dropwort is one of the most poisonous plants in Europe and is NOT a safe dietary supplement or herbal remedy. Every part of the plant is toxic, and even small amounts can cause seizures, heart problems, and death. Do not consume it in any form.

Oenanthe crocata · Apiaceae · Whole plant, especially the roots (highly toxic) · Not used as a supplement; the plant is a poisonous wild herb

An interaction check asks whether these two react with each other — it does not ask whether Hemlock Water Dropwort is a good idea for someone in your situation. Here is what our Hemlock Water Dropwort record says about it on its own.

Hemlock Water Dropwort: dosing

There is no safe dose of hemlock water dropwort. The only correct "dose" is none at all.

From our Hemlock Water Dropwort monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hemlock Water Dropwort monograph & all interactions
Medication

About Naloxegol

What Is Naloxegol Used For?

Brand name: Movantik

Movantik (naloxegol) is used to treat opioid-induced constipation (OIC) — constipation caused by opioid pain medications — in adults who have chronic non-cancer pain. It is also approved for adults with chronic pain related to prior cancer or its treatment, as long as they don't need frequent (roughly weekly) increases in their opioid dose.

It is not indicated for constipation from other causes, and it is not approved for use in children.

Most-Reported Side Effects for Naloxegol

From FAERS, the FDA’s public side-effect reporting system (3,902 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 380 reports
Constipation 375 reports
Nausea 329 reports
Abdominal pain 258 reports
Abdominal pain upper 228 reports
See full Naloxegol drug information
Keep checking

Other Drugs & Hemlock Water Dropwort

Browse every other medication we’ve checked against Hemlock Water Dropwort — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Hemlock Water Dropwort against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Hemlock Water Dropwort list.

See the full Hemlock Water Dropwort interactions page
See every supplement checked against Naloxegol, ranked by severity
Evidence & sources

Hemlock Water Dropwort References

The 4 references that drive our Hemlock Water Dropwort monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Fitzgerald P, Moss N, O'Mahony S, Whelton MJ. Accidental hemlock poisoning. Br Med J (Clin Res Ed) 1987;295:1657. PubMed
  2. Mitchell MI, Routledge PA. Hemlock water dropwort poisoning-a review. Clin Toxicol 1978;12:417-26. PubMed
  3. Ball MJ, Flather ML, Forfar JC. Hemlock water dropwort poisoning. Postgrad Med J 1987;63:363-5. PubMed
  4. Henry FJ, Cadiet J, Javaudin F, Rozec B. Oenantha Crocata: A Case Report of Multiple Poisoning with Fatal Outcome. J Emerg Med. 2020;59(1):e9-e11. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hemlock Water Dropwort and Naloxegol Together: Common Questions

Is it safe to take Hemlock Water Dropwort with Naloxegol?
We do not list a known interaction between Hemlock Water Dropwort and Naloxegol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Hemlock Water Dropwort and Naloxegol have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Hemlock Water Dropwort and Naloxegol at the same time of day?
At least one FDA label for a product containing Naloxegol says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Naloxegol on its own and move Hemlock Water Dropwort to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Does Naloxegol interact with any supplements?
Yes. Naloxegol has documented interactions with 138 supplements in our database — Hemlock Water Dropwort is not one of them. The Naloxegol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hemlock Water Dropwort monograph Uses, safety profile, and every drug interaction in one place Naloxegol drug information The full plain-English guide to this medication Naloxegol supplement interactions Every supplement checked against Naloxegol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Naloxegol and Hemlock Water Dropwort?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.