Drug & supplement interaction

Hempnettle + Dihydroergotamine

Dihydroergotamine brand names: Migranal, DHE-45.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Hempnettle and Dihydroergotamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Hempnettle and Dihydroergotamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Dihydroergotamine and Hempnettle in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Hempnettle at all — not against Dihydroergotamine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hempnettle safety at a glance

Hempnettle overall Not established There is very little modern research on its safety or effective dose.
Pregnancy Avoid Safety has not been established, so avoid use during pregnancy.
Breastfeeding Avoid Not enough is known about safety while breastfeeding, so avoid it.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Dihydroergotamine and Hempnettle? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Dihydroergotamine’s Own FDA Label Lists

This is not an interaction — none of it involves Hempnettle. These are the most notable effects listed in the ADVERSE REACTIONS section of Dihydroergotamine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 5 of them are worth acting on rather than waiting out — marked below.

  • A heart attack Worth acting on
  • Shortness of breath Worth acting on mentioned in 6.9% of FDA reports for Dihydroergotamine
  • An irregular heartbeat Worth acting on
  • Raised blood pressure Worth acting on
  • Sweating mentioned in 25.5% of FDA reports for Dihydroergotamine
  • An allergic reaction Worth acting on
  • Flushing
  • A fast or pounding heartbeat
  • Numbness or tingling
  • Anxiety or restlessness

Showing the 10 most notable of 14 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Dihydroergotamine. Read the label on DailyMed › Where a percentage is shown, it is the share of 1,268 voluntary FDA FAERS reports for Dihydroergotamine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Hempnettle’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Hempnettle side to compare — that is a limit of the record, not a statement that Hempnettle has no side effects.

Everything else you take

See Every Supplement That Interacts With Dihydroergotamine

This page covers Hempnettle only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dihydroergotamine page lists 156 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 5-htp (moderate).

By severity: 4 major · 110 moderate · 42 minor.

From our pharmacist’s overview on the Dihydroergotamine page

“Dihydroergotamine (Migranal, DHE-45) stops migraines by tightening blood vessels, and this interaction list deserves genuine care. Four of its 156 supplement interactions rate major, and the largest theme, covering 121 ingredients, involves the CYP3A4 enzyme that clears the drug.”

Reviewed by 2 · Jul 18, 2026

Open the Dihydroergotamine interaction page

One more smart check

Taking Hempnettle as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4 real supplement products containing Hempnettle, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Hempnettle. Even though Hempnettle itself has no known interaction with Dihydroergotamine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Hempnettle and Dihydroergotamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hempnettle
Steady interest

#926 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dihydroergotamine
Steady interest

#2,164 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Hempnettle is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hempnettle reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Hempnettle and Dihydroergotamine records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Hempnettle

What is Hempnettle?

  • Coughs and chest congestion
  • Mild respiratory complaints
  • General tonic
  • Soothing irritated airways

Hempnettle is a traditional European herb that has been used as a tea for coughs and minor respiratory complaints, but there is very little modern scientific research to support these uses. Because its safety and effectiveness are not well studied, it is best to talk with a pharmacist or doctor before trying it, and to avoid it during pregnancy and breastfeeding.

Galeopsis tetrahit · Lamiaceae · Aerial parts (flowering tops, leaves, and stems) · Tea (infusion), liquid extract, dried herb

An interaction check asks whether these two react with each other — it does not ask whether Hempnettle is a good idea for someone in your situation. Here is what our Hempnettle record says about it on its own.

Hempnettle: dosing

There is no established, science-based dose for hempnettle. A standard safe and effective amount has not been determined in research.If you choose to use a product that contains it, follow the directions on the product label and do not exceed the suggested amount. Because doses and product strengths vary widely, it is a good idea to review the product with a pharmacist before using it.

From our Hempnettle monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hempnettle monograph & all interactions
Medication

About Dihydroergotamine Injection

What Is Dihydroergotamine Injection Used For?

Brand names: Migranal, DHE-45

Dihydroergotamine injection is used to stop a migraine headache once it has started — with or without the visual or sensory warning signs known as aura. It is also used to treat cluster headaches in adults.

It is not used to prevent migraines from happening, and it is not for hemiplegic migraine (migraine that causes temporary paralysis) or migraine with brainstem aura. Brekiya is specifically approved for subcutaneous (under-the-skin) self-injection using an autoinjector device.

Most-Reported Side Effects for Dihydroergotamine

From FAERS, the FDA’s public side-effect reporting system (1,268 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 365 reports
Hyperhidrosis 323 reports
Nightmare 308 reports
Sedation 308 reports
Nephrolithiasis 222 reports
See full Dihydroergotamine Injection drug information
Keep checking

Other Drugs & Hempnettle

Browse every other medication we’ve checked against Hempnettle — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Hempnettle against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Hempnettle list.

See the full Hempnettle interactions page
See every supplement checked against Dihydroergotamine, ranked by severity
Evidence & sources

Hempnettle References

The 2 sources that drive our Hempnettle monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Hempnettle is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Herbs at a Glance — NIH NCCIH Source
  2. Herbs and Supplements — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hempnettle and Dihydroergotamine Together: Common Questions

Is it safe to take Hempnettle with Dihydroergotamine?
We do not list a known interaction between Hempnettle and Dihydroergotamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Dihydroergotamine interact with any supplements?
Yes. Dihydroergotamine has documented interactions with 156 supplements in our database — Hempnettle is not one of them. The Dihydroergotamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hempnettle monograph Uses, safety profile, and every drug interaction in one place Dihydroergotamine Injection drug information The full plain-English guide to this medication Dihydroergotamine supplement interactions Every supplement checked against Dihydroergotamine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Dihydroergotamine and Hempnettle?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.