Drug & supplement interaction

Hesperidin + Albendazole

Albendazole brand name: Albenza.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Hesperidin and Albendazole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Albendazole states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Hesperidin and Albendazole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Albendazole and Hesperidin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hesperidin safety at a glance

Hesperidin overall Use caution Generally well tolerated in food amounts and short-term supplement use, but high-quality long-term data is limited.
Pregnancy Likely Safe When used orally in amounts found in foods. Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in amounts found in foods. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Albendazole and Hesperidin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Albendazole

Interactions in our licensed database are recorded against drug classes, not just single drug names. Albendazole is filed under 2 classifications — cytochrome p450 1a2 (cyp1a2) inducers, oral drugs. Hesperidin has documented interactions with 7 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antihypertensive drugs (moderate) and celiprolol (celicard) (moderate) — and none of Albendazole’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Hesperidin Does Interact With Other Medications

Hesperidin has 702 moderate known drug interactions in our database — Albendazole isn’t one of them. If you take anything else, check it against the full list below.

Moderate 702 No known interaction 2,128 (incl. Albendazole)
Taking anything else?

Check Another of Your Medications Against Hesperidin

Covers the 2,830 medications we’ve checked against Hesperidin. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Hesperidin and Albendazole May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A skin rash reported in 9.1% of FDA reports for Albendazole Additional detail

    Hesperidin

    “A case of recurrent allergic dermatitis was reported in a 70-year-old female with no known allergies who applied topical hesperidin methyl chalchone.”

    Hesperidin · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    1 source cited
    1. 94538. Andersen KE. Hesperidin methyl chalcone?-?a new cosmetic contact allergen. Contact Dermatitis. 2015;72(6):402-4. PubMed

    Albendazole

    Listed in the ADVERSE REACTIONS section of the FDA label for Albendazole, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Effects for Albendazole come from the ADVERSE REACTIONS section of its FDA label; effects for Hesperidin come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 1,886 voluntary FDA FAERS reports for Albendazole that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Hesperidin in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in amounts found in foods.

Pregnancy And Lactation Possibly Safe

When used orally in doses of up to 100 mg daily for 30 days in combination with diosmin. Some evidence suggests that taking this combination may be associated with placental insufficiency when used during the third trimester of pregnancy; however, the combination does not seem to induce fetal abnormalities, retard fetal growth, increase the risk of intrauterine death, or affect birth weight. Also, when breastfeeding, this combination does not seem to affect infant growth or feeding.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Albendazole Products Have a Food Rule — Hesperidin Should Not Break It

At least one FDA label for a product containing Albendazole says to take it with food. If you take Hesperidin on an empty stomach out of habit, keep them separate — and take Albendazole with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Albendazole products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Albendazole tablets should be taken with food.

From the Dosage and Administration section of the FDA label we read for Albendazole — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Hesperidin or Albendazole

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Hesperidin or Albendazole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Albendazole

This page covers Hesperidin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Albendazole page lists 18 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 8 moderate · 9 minor.

From our pharmacist’s overview on the Albendazole page

“Activated charcoal is the one entry here I would treat as a genuine hazard with albendazole. It soaks up drugs in the gut, and albendazole, an antiparasitic taken for worm and tapeworm infections, is already absorbed poorly to begin with.”

Reviewed by 2 · Jul 18, 2026

Open the Albendazole interaction page

One more smart check

Taking Hesperidin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,895 real supplement products containing Hesperidin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Hesperidin. Even though Hesperidin itself has no known interaction with Albendazole, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Hesperidin and Albendazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hesperidin
Top 25%

#167 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Albendazole
Steady interest

#1,739 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hesperidin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Hesperidin and Albendazole records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Hesperidin

What is Hesperidin?

Hesperidin
  • Hemorrhoids
  • Varicose veins and poor circulation
  • Leg swelling (venous insufficiency)
  • High blood pressure
  • Antioxidant support

Hesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrhoids and varicose veins. Some evidence supports these uses, but data for many other claims is limited. It is generally well tolerated, but pregnant and breastfeeding people should avoid it because safety has not been established.

Rutaceae · Fruit and peel of citrus fruits (especially oranges and lemons) · Capsules, tablets, often combined with diosmin or vitamin C as a bioflavonoid complex

An interaction check asks whether these two react with each other — it does not ask whether Hesperidin is a good idea for someone in your situation. Here is what our Hesperidin record says about it on its own.

Hesperidin: dosing

There is no official standardized dose of hesperidin. The amount used in research varies depending on the product and whether it is combined with diosmin or other ingredients.The best approach is to follow the directions on the product label and not exceed the recommended amount.

From our Hesperidin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hesperidin monograph & all interactions
Medication

About Albendazole

What Is Albendazole Used For?

Brand name: Albenza

Albendazole tablets — sold under the brand name Albenza as well as generically — are used to treat two specific parasitic infections. The first is neurocysticercosis, an infection of the brain caused by larval forms of the pork tapeworm (Taenia solium). The second is cystic hydatid disease, an infection of the liver, lungs, or the lining of the abdomen caused by the larval form of the dog tapeworm (Echinococcus granulosus).

Both Albenza (the brand) and generic albendazole tablets are FDA-approved for these same two conditions. Your doctor will determine which form is right for you.

Most-Reported Side Effects for Albendazole

From FAERS, the FDA’s public side-effect reporting system (1,886 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 243 reports
Headache 230 reports
Fatigue 176 reports
Weight decreased 174 reports
Rash 172 reports
See full Albendazole drug information
Keep checking

Other Drugs & Hesperidin

Browse every other medication we’ve checked against Hesperidin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
702Moderate
0Minor
2,127No known interaction
702 Moderate 2,127 No interaction
Moderate

702 interactions

Showing 60 of 702 moderate interactions — see all 702 on the Hesperidin page.

No interaction 2,127 drugs checked — show the list

We also checked Hesperidin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,127 medications checked with no known interaction — see the full Hesperidin list.

See the full Hesperidin interactions page
See every supplement checked against Albendazole, ranked by severity
Evidence & sources

Hesperidin References

The 14 references that drive our Hesperidin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Fernandez, S. P., Wasowski, C., Paladini, A. C., and Marder, M. Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. Eur.J.Pharmacol. 4-11-2005;512(2-3):189-198. PubMed
  2. Jin, Y. R., Han, X. H., Zhang, Y. H., Lee, J. J., Lim, Y., Chung, J. H., and Yun, Y. P. Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity. Atherosclerosis 200
  3. Loscalzo, L. M., Wasowski, C., Paladini, A. C., and Marder, M. Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines. Eur.J.Pharmacol. 2-12-2008;580(3):306-313. PubMed
  4. Yamamoto, M., Suzuki, A., Jokura, H., Yamamoto, N., and Hase, T. Glucosyl hesperidin prevents endothelial dysfunction and oxidative stress in spontaneously hypertensive rats. Nutrition 2008;24(5):470-476. PubMed
  5. El-Readi, M. Z., Hamdan, D., Farrag, N., El-Shazly, A., and Wink, M. Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines. Eur.J.Pharmacol. 1-25-2010;626(2-3):139-145 PubMed
  6. Buckshee, K., Takkar, D., and Aggarwal, N. Micronized flavonoid therapy in internal hemorrhoids of pregnancy. Int J Gynaecol Obstet 1997;57(2):145-151. PubMed
  7. Uesawa, Y. and Mohri, K. Hesperidin in orange juice reduces the absorption of celiprolol in rats. Biopharm Drug Dispos. 2008;29(3):185-188. PubMed
  8. Cho, YA, Choi, DH, and Choi, JS. Effect of hesperidin on the oral pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats. J Pharm Pharmacol. 2009;61(6):825-829. PubMed
  9. Piao, YJ and Choi, JS. Enhanced bioavailability of verapamil after oral administration with hesperidin in rats. Arch Pharm Res. 2008;31(4):518-522. PubMed
  10. Andersen KE. Hesperidin methyl chalcone?-?a new cosmetic contact allergen. Contact Dermatitis. 2015;72(6):402-4. PubMed
  11. Morand C, Dubray C, Milenkovic D, et al. Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. Am J Clin Nutr 2011;93(1):73-80. PubMed
  12. Homayouni F, Haidari F, Hedayati M, Zakerkish M, Ahmadi K. Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial. Phytother Res. 2018;32(6):1073-1079. PubMed
  13. Mohammadi M, Ramezani-Jolfaie N, Lorzadeh E, Khoshbakht Y, Salehi-Abargouei A. Hesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta-analysis of randomized controlled clinical trials PubMed
  14. Valls RM, Pedret A, Calderón-Pérez L, et al. Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study). Eur J Nutr. 2021;60(3):1277-1288. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hesperidin and Albendazole Together: Common Questions

Is it safe to take Hesperidin with Albendazole?
We do not list a known interaction between Hesperidin and Albendazole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Hesperidin and Albendazole have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Hesperidin and Albendazole at the same time of day?
At least one FDA label for a product containing Albendazole says to take it with food. If you take Hesperidin on an empty stomach out of habit, keep them separate and take Albendazole with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Albendazole products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Hesperidin and Albendazole combination checked?
Interactions in our licensed database are recorded against drug classes. Albendazole is filed under 2 classifications, and Hesperidin has documented interactions with 7 drug classes — none of Albendazole's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Hesperidin interact with any other medications?
Yes. Hesperidin has 702 documented drug interactions in our database — Albendazole is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Albendazole interact with any supplements?
Yes. Albendazole has documented interactions with 18 supplements in our database — Hesperidin is not one of them. The Albendazole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hesperidin monograph Uses, safety profile, and every drug interaction in one place Albendazole drug information The full plain-English guide to this medication Albendazole supplement interactions Every supplement checked against Albendazole, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 14 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Albendazole and Hesperidin?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.