Histidine + Tipiracil Hydrochloride, Trifluridine
Tipiracil Hydrochloride, Trifluridine brand name: Lonsurf.
We found no known interaction between Histidine and Tipiracil Hydrochloride, Trifluridine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Tipiracil Hydrochloride, Trifluridine states a food rule worth keeping to.
Histidine and Tipiracil Hydrochloride, Trifluridine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Tipiracil Hydrochloride, Trifluridine and Histidine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Histidine at all — not against Tipiracil Hydrochloride, Trifluridine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Histidine safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Histidine in Pregnancy & Breastfeeding
When used orally in the amounts found in foods. There is insufficient reliable information available about the safety of histidine when used in larger amounts during pregnancy or lactation.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Tipiracil Hydrochloride, Trifluridine Products Have a Food Rule — Histidine Should Not Break It
At least one FDA label for a product containing Tipiracil Hydrochloride, Trifluridine says to take it with food. If you take Histidine on an empty stomach out of habit, keep them separate — and take Tipiracil Hydrochloride, Trifluridine with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Tipiracil Hydrochloride, Trifluridine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
2 DOSAGE AND ADMINISTRATION Recommended Dosage : 35 mg/m 2 /dose orally twice daily with food on Days 1 through 5 and Days 8 through 12 of each 28-day cycle.
From the Dosage and Administration section of the FDA label we read for Tipiracil Hydrochloride, Trifluridine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Tipiracil Hydrochloride, Trifluridine
This page covers Histidine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tipiracil Hydrochloride, Trifluridine page lists 17 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).
By severity: 1 major · 7 moderate · 9 minor.
Open the Tipiracil Hydrochloride, Trifluridine interaction page
Taking Histidine as Part of a Dietary Supplement Product? Check It for Interactions
We hold 1,921 real supplement products containing Histidine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Histidine. Even though Histidine itself has no known interaction with Tipiracil Hydrochloride, Trifluridine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Histidine and Tipiracil Hydrochloride, Trifluridine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#126 of 1,452 supplements looked up here in the last 7 days
#1,836 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Histidine is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Histidine reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Histidine and Tipiracil Hydrochloride, Trifluridine records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Histidine
What is Histidine?
- Skin conditions like eczema
- Anemia related to kidney disease
- Allergy and inflammation support
- General amino acid supplementation
- Athletic and protein supplementation
Histidine is an essential amino acid your body needs to build proteins and to make compounds like histamine and carnosine. Most people get enough from a normal diet, and good-quality research supporting histidine supplements for specific health conditions is limited. If you are considering a supplement, talk with a pharmacist or doctor first.
Amino acid (typically made commercially through fermentation) · Capsules, tablets, powder, part of amino acid blends and protein supplements
An interaction check asks whether these two react with each other — it does not ask whether Histidine is a good idea for someone in your situation. Here is what our Histidine record says about it on its own.
Histidine: dosing
There is no well-established standard supplement dose of histidine for treating health conditions. Amounts used in research have varied widely depending on the purpose.If you choose to use a histidine product, follow the directions on the label and do not exceed the recommended amount.
From our Histidine monograph — the full record covers uses, side effects and every documented interaction.
About Trifluridine and Tipiracil
What Is Trifluridine and Tipiracil Used For?
Brand name: Lonsurf
Lonsurf (trifluridine and tipiracil) is used to treat adults with metastatic colorectal cancer — either alone or combined with bevacizumab — after prior treatment with several other chemotherapy regimens and targeted therapies.
Lonsurf is also used for adults with metastatic gastric or gastroesophageal junction adenocarcinoma (cancer of the stomach or where the stomach meets the esophagus) who have already received at least two prior chemotherapy regimens.
Other Drugs & Histidine
Browse every other medication we’ve checked against Histidine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Histidine against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Tadalafil ›
- Abemaciclib ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Valacyclovir ›
- Ibuprofen ›
- Tirzepatide ›
- Methamphetamine ›
- Warfarin Sodium ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Amitriptyline ›
- Bendamustine ›
- Acyclovir ›
- Methotrexate ›
- Doxycycline ›
- Fluoxetine ›
- Amphetamine ›
- Pregabalin ›
- Lamotrigine ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Gabapentin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Clonazepam ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Omeprazole ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Histidine list.
Histidine References
The 3 sources that drive our Histidine monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Histidine is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Histidine — MedlinePlus (U.S. National Library of Medicine) Source
- Amino Acids — MedlinePlus (U.S. National Library of Medicine) Source
- Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Histidine and Tipiracil Hydrochloride, Trifluridine Together: Common Questions
Is it safe to take Histidine with Tipiracil Hydrochloride, Trifluridine?
Should I take Histidine and Tipiracil Hydrochloride, Trifluridine at the same time of day?
Does Tipiracil Hydrochloride, Trifluridine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.