Drug & supplement interaction

Histidine + Losartan Potassium

Losartan Potassium brand name: Cozaar.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Histidine and Losartan Potassium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Histidine and Losartan Potassium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Losartan Potassium and Histidine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Histidine at all — not against Losartan Potassium, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Histidine safety at a glance

Histidine overall Use caution Likely safe in amounts found in food, but the safety of higher supplement doses is not well established.
Pregnancy Likely Safe When used orally in the amounts found in foods. There is insufficient reliable information available about the safety of histidine when used in larger amounts d... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in the amounts found in foods. There is insufficient reliable information available about the safety of histidine when used in larger amounts d... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Losartan Potassium and Histidine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Losartan Potassium’s Own FDA Label Lists

This is not an interaction — none of it involves Histidine. These are the most notable effects listed in the ADVERSE REACTIONS section of Losartan Potassium’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Severe muscle breakdown Worth acting on
  • Muscle weakness Worth acting on
  • High potassium Worth acting on
  • Low sodium Worth acting on
  • Low blood sugar Worth acting on
  • Fainting Worth acting on
  • An irregular heartbeat Worth acting on
  • Shortness of breath Worth acting on mentioned in 5.2% of FDA reports for Losartan Potassium
  • Chest pain Worth acting on
  • Low mood Worth acting on

Showing the 10 most notable of 44 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Losartan Potassium. Read the label on DailyMed › Where a percentage is shown, it is the share of 89,498 voluntary FDA FAERS reports for Losartan Potassium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Histidine’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Histidine side to compare — that is a limit of the record, not a statement that Histidine has no side effects.

Special populations

Histidine in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in the amounts found in foods. There is insufficient reliable information available about the safety of histidine when used in larger amounts during pregnancy or lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Losartan Potassium Is Prescribed For, and What Histidine Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Losartan Potassium is a prescription medicine with approved uses on its FDA label. Histidine is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Losartan Potassium is prescribed for: Losartan tablets — available as branded Cozaar and several generic products — are used to treat high blood pressure (hypertension) in adults and children 6 years and older. Lowering blood pressure reduces the risk of strokes and heart attacks. Losartan tablets are also used to reduce the risk of stroke in people with high blood pressure who also have left ventricular hypertrophy (an enlarged left side of the heart). Note: evidence suggests this stroke-risk benefit may not apply to Black patients.

Read the rest of what Losartan Potassium is prescribed for

Losartan tablets are additionally approved to protect the kidneys in people with type 2 diabetes, high blood pressure, and signs of kidney damage (diabetic nephropathy). Arbli, the oral suspension form, shares these same approved uses.

Histidine has been studied for:

  • Kidney failure studied, not established Histidine has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Histidine for kidney failure

    It is unclear if oral L-histidine is beneficial for anemia in patients with kidney failure.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Losartan Potassium on your own; if you are taking Histidine for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Histidine or Losartan Potassium

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Histidine or Losartan Potassium, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Losartan Potassium

This page covers Histidine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Losartan Potassium page lists 253 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Grapefruit (major) and St. John's Wort (major).

By severity: 6 major · 205 moderate · 42 minor.

From our pharmacist’s overview on the Losartan Potassium page

“Losartan potassium (Cozaar) treats high blood pressure, and this is a list to respect, because six of its 253 supplement interactions carry a major rating. Most entries do one of two things.”

Reviewed by 2 · Jul 18, 2026

Open the Losartan Potassium interaction page

One more smart check

Taking Histidine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,921 real supplement products containing Histidine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Histidine. Even though Histidine itself has no known interaction with Losartan Potassium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Histidine and Losartan Potassium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Histidine
Top 10%

#120 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Losartan Potassium
Top 10

#6 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Histidine is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Histidine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Histidine and Losartan Potassium records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Histidine

What is Histidine?

  • Skin conditions like eczema
  • Anemia related to kidney disease
  • Allergy and inflammation support
  • General amino acid supplementation
  • Athletic and protein supplementation

Histidine is an essential amino acid your body needs to build proteins and to make compounds like histamine and carnosine. Most people get enough from a normal diet, and good-quality research supporting histidine supplements for specific health conditions is limited. If you are considering a supplement, talk with a pharmacist or doctor first.

Amino acid (typically made commercially through fermentation) · Capsules, tablets, powder, part of amino acid blends and protein supplements

An interaction check asks whether these two react with each other — it does not ask whether Histidine is a good idea for someone in your situation. Here is what our Histidine record says about it on its own.

Histidine: dosing

There is no well-established standard supplement dose of histidine for treating health conditions. Amounts used in research have varied widely depending on the purpose.If you choose to use a histidine product, follow the directions on the label and do not exceed the recommended amount.

From our Histidine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Histidine monograph & all interactions
Medication

About Losartan

What Is Losartan Used For?

Brand name: Cozaar

Losartan tablets — available as branded Cozaar and several generic products — are used to treat high blood pressure (hypertension) in adults and children 6 years and older. Lowering blood pressure reduces the risk of strokes and heart attacks. Losartan tablets are also used to reduce the risk of stroke in people with high blood pressure who also have left ventricular hypertrophy (an enlarged left side of the heart). Note: evidence suggests this stroke-risk benefit may not apply to Black patients.

Losartan tablets are additionally approved to protect the kidneys in people with type 2 diabetes, high blood pressure, and signs of kidney damage (diabetic nephropathy). Arbli, the oral suspension form, shares these same approved uses.

Most-Reported Side Effects for Losartan Potassium

From FAERS, the FDA’s public side-effect reporting system (89,498 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 6,464 reports
Nausea 5,301 reports
Diarrhea 5,184 reports
Dyspnea 4,689 reports
Dizziness 4,429 reports
See full Losartan drug information
Keep checking

Other Drugs & Histidine

Browse every other medication we’ve checked against Histidine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Histidine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Histidine list.

See the full Histidine interactions page
See every supplement checked against Losartan Potassium, ranked by severity
Evidence & sources

Histidine References

The 3 sources that drive our Histidine monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Histidine is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Histidine — MedlinePlus (U.S. National Library of Medicine) Source
  2. Amino Acids — MedlinePlus (U.S. National Library of Medicine) Source
  3. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Histidine and Losartan Potassium Together: Common Questions

Is it safe to take Histidine with Losartan Potassium?
We do not list a known interaction between Histidine and Losartan Potassium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Histidine and Losartan Potassium used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Histidine in each. That is a conversation for your prescriber, especially if Losartan Potassium is being adjusted to a target.
Does Losartan Potassium interact with any supplements?
Yes. Losartan Potassium has documented interactions with 253 supplements in our database — Histidine is not one of them. The Losartan Potassium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Histidine monograph Uses, safety profile, and every drug interaction in one place Losartan drug information The full plain-English guide to this medication Losartan Potassium supplement interactions Every supplement checked against Losartan Potassium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Losartan Potassium and Histidine?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.