Holly + Dolutegravir, Rilpivirine
Dolutegravir, Rilpivirine brand name: Juluca.
We found no known interaction between Holly and Dolutegravir, Rilpivirine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Dolutegravir, Rilpivirine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Holly and Dolutegravir, Rilpivirine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Dolutegravir, Rilpivirine and Holly in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Holly at all — not against Dolutegravir, Rilpivirine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Holly safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Holly in Pregnancy & Breastfeeding
When berries are ingested. There is insufficient reliable information available about the safety of holly leaves; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Dolutegravir, Rilpivirine Products Have a Food Rule — Holly Should Not Break It
At least one FDA label for a product containing Dolutegravir, Rilpivirine says to take it with food. If you take Holly on an empty stomach out of habit, keep them separate — and take Dolutegravir, Rilpivirine with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Dolutegravir, Rilpivirine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
( 2.2 ) 2.1 Recommended Dosage The recommended dosage of JULUCA is one tablet taken orally once daily with a meal [see Clinical Pharmacology ( 12.3 )] .
From the Dosage and Administration section of the FDA label we read for Dolutegravir, Rilpivirine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Dolutegravir, Rilpivirine
This page covers Holly only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dolutegravir, Rilpivirine page lists 159 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Calcium (major) and Cesium (major).
By severity: 9 major · 115 moderate · 35 minor.
From our pharmacist’s overview on the Dolutegravir, Rilpivirine page
“Juluca combines dolutegravir and rilpivirine into a single daily HIV pill, and staying suppressed depends on that pill working at full strength every day, which is why this list calls for real vigilance. Most of the 159 interacting supplements and herbs change how the body handles the medication, some raising its levels and others lowe…”
Reviewed by 2 · Jul 18, 2026
Taking Holly as Part of a Dietary Supplement Product? Check It for Interactions
We hold 11 real supplement products containing Holly, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Holly. Even though Holly itself has no known interaction with Dolutegravir, Rilpivirine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Holly and Dolutegravir, Rilpivirine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,324 of 1,452 supplements looked up here in the last 7 days
#1,922 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Holly reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Holly and Dolutegravir, Rilpivirine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Holly
What is Holly?
- Fever
- Cough and chest congestion
- Joint pain (traditional use)
- Digestive complaints
- Mild diuretic
Holly (Ilex aquifolium) is a common ornamental shrub whose bright red berries are poisonous and should never be eaten. There is very little reliable human evidence supporting any health benefit of holly leaves, and because of safety concerns it is generally best avoided as a supplement unless guided by a knowledgeable healthcare professional.
Ilex aquifolium · Aquifoliaceae · Leaves and berries (and bark in some traditions) · Dried leaf tea, tinctures, and homeopathic preparations; berries are not used as a supplement
An interaction check asks whether these two react with each other — it does not ask whether Holly is a good idea for someone in your situation. Here is what our Holly record says about it on its own.
Holly: dosing
There is no established or standardized dose for holly, because it has not been properly studied as a medicine. We cannot provide a safe recommended amount.If you choose to use a commercial holly product despite the limited evidence, follow the directions on the label exactly and never exceed them.
From our Holly monograph — the full record covers uses, side effects and every documented interaction.
Other Drugs & Holly
Browse every other medication we’ve checked against Holly — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Holly against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Holly list.
Holly References
The 2 references that drive our Holly monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Holly and Dolutegravir, Rilpivirine Together: Common Questions
Is it safe to take Holly with Dolutegravir, Rilpivirine?
Do Holly and Dolutegravir, Rilpivirine have any of the same side effects?
Should I take Holly and Dolutegravir, Rilpivirine at the same time of day?
Does Dolutegravir, Rilpivirine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.