Drug & supplement interaction

Hyland's Restless Legs + Dronabinol

Dronabinol brand names: Marinol, Syndros.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Hyland's Restless Legs and Dronabinol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Hyland's Restless Legs and Dronabinol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Dronabinol and Hyland's Restless Legs in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Hyland's Restless Legs at all — not against Dronabinol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hyland's Restless Legs safety at a glance

Hyland's Restless... overall Use caution Generally low risk because ingredients are highly diluted, but it is not proven to work and is not a substitute for medical evaluation.
Pregnancy Use caution Safety is not well established, so avoid use unless your doctor or pharmacist approves.
Breastfeeding Use caution Safety while breastfeeding is not well established, so check with your doctor or pharmacist first.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Pharmacist analysis

In most situations, clinically significant interactions between homeopathic products and prescription or over-the-counter medications are extremely unlikely.

Homeopathic medications, which utilize the principle of 'like cures like', are often highly diluted substances. These dilutions are typically so high that the final remedy contains only a tiny amount of the original active ingredient, if any at all.

In theory, because the concentration of the active ingredient is so low, homeopathic preparations are unlikely to interact with other medications in the body.

This is certainly the case with Hyland's Restful Legs, with all the ingredients diluted at potencies of 6X or 12X. A potency of 6X means that the original substance has been diluted by a factor of 10^6, or one part in a million (i.e.,  for every million parts of the solution, there is one part of the original substance).

It is important to note that not all homeopathic remedies are free of potential drug interactions as some use very low dilutions (which is often the case with zinc-containing products).

Nevertheless, there are no known drug interactions between Hyland's Restful Legs and other medications. It is also thought to be safe to take along with medications to help sleep, like Benadryl, melatonin, and NyQuil, which are commonly used with the product to help sleep.

—

Still wondering about combining Dronabinol and Hyland's Restless Legs? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Dronabinol’s Own FDA Label Lists

This is not an interaction — none of it involves Hyland's Restless Legs. These are the most notable effects listed in the ADVERSE REACTIONS section of Dronabinol’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 8 of them are worth acting on rather than waiting out — marked below.

  • Memory problems Worth acting on
  • Unsteadiness Worth acting on
  • Hallucinations Worth acting on
  • Fainting Worth acting on
  • Confusion Worth acting on
  • Seizures Worth acting on
  • Hives Worth acting on
  • An allergic reaction Worth acting on
  • Vivid dreams or nightmares
  • Weight loss

Showing the 10 most notable of 31 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Dronabinol. Read the label on DailyMed › Where a percentage is shown, it is the share of 7,993 voluntary FDA FAERS reports for Dronabinol that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Hyland's Restless Legs’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Hyland's Restless Legs side to compare — that is a limit of the record, not a statement that Hyland's Restless Legs has no side effects.

Everything else you take

See Every Supplement That Interacts With Dronabinol

This page covers Hyland's Restless Legs only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dronabinol page lists 151 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 107 moderate · 41 minor.

From our pharmacist’s overview on the Dronabinol page

“A glass of grapefruit juice can push dronabinol (Marinol, Syndros), the prescription form of THC used for chemotherapy nausea and appetite loss, to higher blood levels than intended, amplifying dizziness, sedation, and its mind-altering effects. That is one of three major-rated interactions among the 151 supplements and herbs on file,…”

Reviewed by 2 · Jul 18, 2026

Open the Dronabinol interaction page

How much people look this up

Where Hyland's Restless Legs and Dronabinol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hyland's Restless Legs
Steady interest

#1,193 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dronabinol
Steady interest

#2,451 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Hyland's Restless Legs is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hyland's Restless Legs reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Hyland's Restless Legs and Dronabinol records this page draws on were last updated June 20, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Hyland's Restless Legs

What is Hyland's Restless Legs?

Hyland's Restless Legs
  • Restless legs sensations
  • Urge to move the legs
  • Leg twitching or jerking
  • Crawling or itching feelings in the legs
  • Trouble resting due to leg discomfort

Hyland's Restful Legs (often called 'Restless Legs') is a homeopathic product marketed to calm agitated legs so you can rest. Its ingredients are extremely diluted, and there is no strong scientific evidence that it relieves restless legs syndrome. If you have ongoing leg symptoms, talk with a pharmacist or doctor, since restless legs can have treatable underlying causes such as low iron.

Highly diluted homeopathic ingredients (not a single plant part) · Quick-dissolving tablets (daytime and nighttime/PM versions)

An interaction check asks whether these two react with each other — it does not ask whether Hyland's Restless Legs is a good idea for someone in your situation. Here is what our Hyland's Restless Legs record says about it on its own.

Hyland's Restless Legs: dosing

There is no scientifically established dose for this product, since it has not been proven effective in clinical trials. Always follow the directions on the package label. Do not exceed the labeled amount, and do not use it as a substitute for treatments your doctor has recommended.

From our Hyland's Restless Legs monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hyland's Restless Legs monograph & all interactions
Medication

About Dronabinol

What Is Dronabinol Used For?

Brand names: Marinol, Syndros

Dronabinol — available as capsules (Marinol, Dronabinol) and as an oral solution (Syndros, Dronabinol oral solution) — is approved for two conditions in adults. First, it treats anorexia (severely reduced appetite) associated with weight loss in patients with AIDS. Second, it controls nausea and vomiting caused by cancer chemotherapy in patients who have not gotten enough relief from standard anti-nausea treatments.

Both uses apply to all available formulations, but dosing timing and meal instructions differ between the capsule and oral solution products. Always follow the specific instructions for the product you have been prescribed.

Most-Reported Side Effects for Dronabinol

From FAERS, the FDA’s public side-effect reporting system (7,993 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 894 reports
Fatigue 708 reports
Diarrhea 615 reports
Vomiting 591 reports
Decreased appetite 452 reports
See full Dronabinol drug information
Keep checking

Other Drugs & Hyland's Restless Legs

Browse every other medication we’ve checked against Hyland's Restless Legs — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Hyland's Restless Legs against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Hyland's Restless Legs list.

See the full Hyland's Restless Legs interactions page
See every supplement checked against Dronabinol, ranked by severity
Evidence & sources

Hyland's Restless Legs References

The 3 sources that drive our Hyland's Restless Legs monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Hyland's Restless Legs is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Homeopathy — NIH NCCIH Source
  2. Restless Legs Syndrome — MedlinePlus Source
  3. Homeopathic Products — U.S. Food and Drug Administration Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hyland's Restless Legs and Dronabinol Together: Common Questions

Is it safe to take Hyland's Restless Legs with Dronabinol?
We do not list a known interaction between Hyland's Restless Legs and Dronabinol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Dronabinol interact with any supplements?
Yes. Dronabinol has documented interactions with 151 supplements in our database — Hyland's Restless Legs is not one of them. The Dronabinol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hyland's Restless Legs monograph Uses, safety profile, and every drug interaction in one place Dronabinol drug information The full plain-English guide to this medication Dronabinol supplement interactions Every supplement checked against Dronabinol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Dronabinol and Hyland's Restless Legs?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.