Drug & supplement interaction

Hyssop + Naproxen

Naproxen brand names: Naprosyn, Naprelan, Anaprox, Anaprox DS, Naproxyn, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Hyssop and Naproxen in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Hyssop and Naproxen

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Naproxen and Hyssop in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Hyssop at all — not against Naproxen, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hyssop safety at a glance

Hyssop overall Use caution The herb is likely low-risk in small culinary or tea amounts, but the essential oil can be toxic and cause seizures.
Pregnancy Likely Unsafe When used orally. Hyssop may produce uterine stimulant and menstrual stimulant effects. Read the full pregnancy detail
Breastfeeding Avoid There is not enough safety information, so it is best avoided while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Naproxen and Hyssop? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Naproxen’s Own FDA Label Lists

This is not an interaction — none of it involves Hyssop. These are the most notable effects listed in the ADVERSE REACTIONS section of Naproxen’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Bone thinning Worth acting on
  • Pain or burning when passing urine Worth acting on
  • Muscle weakness Worth acting on
  • Memory problems Worth acting on
  • Dehydration Worth acting on
  • Trouble swallowing Worth acting on
  • Bleeding in the gut Worth acting on
  • Trouble passing urine Worth acting on
  • High potassium Worth acting on
  • Low blood sugar Worth acting on

Showing the 10 most notable of 76 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Naproxen. Read the label on DailyMed › Where a percentage is shown, it is the share of 165,062 voluntary FDA FAERS reports for Naproxen that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Hyssop’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Hyssop side to compare — that is a limit of the record, not a statement that Hyssop has no side effects.

Special populations

Hyssop in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. Hyssop may produce uterine stimulant and menstrual stimulant effects.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Naproxen Is Prescribed For, and What Hyssop Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Naproxen is a prescription medicine with approved uses on its FDA label. Hyssop is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Naproxen is prescribed for: Naproxen tablets, naproxen sodium tablets, and naproxen oral suspension are used to relieve the signs and symptoms of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and polyarticular juvenile idiopathic arthritis. They are also used for tendonitis, bursitis, and acute gout, and for managing pain and primary dysmenorrhea (menstrual cramps). Naproxen Sodium Controlled-Release Tablets are indicated for the same conditions plus the relief of mild to moderate pain. Several over-the-counter naproxen sodium products are indicated for the temporary relief of minor aches and pains from headache, backache, muscular aches, toothache, menstrual cramps, minor arthritis pain, and the common cold, and to temporarily reduce fever.

Hyssop has been studied for:

  • Dysmenorrhea studied, not established Hyssop has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Hyssop for dysmenorrhea

    Although there has been interest in using oral hyssop for dysmenorrhea, there is insufficient reliable information about the clinical effects of hyssop for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Naproxen on your own; if you are taking Hyssop for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Hyssop or Naproxen

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Hyssop or Naproxen, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Naproxen

This page covers Hyssop only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Naproxen page lists 311 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 260 moderate · 44 minor.

Open the Naproxen interaction page

One more smart check

Taking Hyssop as Part of a Dietary Supplement Product? Check It for Interactions

We hold 274 real supplement products containing Hyssop, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Hyssop. Even though Hyssop itself has no known interaction with Naproxen, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Hyssop and Naproxen Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hyssop
Top half

#442 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Naproxen
Top 5%

#56 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hyssop reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Hyssop and Naproxen records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Hyssop

What is Hyssop?

Hyssop
  • Coughs and colds
  • Sore throat and congestion
  • Digestive upset and gas
  • Aromatherapy
  • Insect repellent

Hyssop is a Mediterranean mint-family herb traditionally used for coughs, colds, and digestive complaints, but solid human evidence for these uses is lacking. The dried herb in tea is generally considered low-risk for most adults, but the concentrated essential oil can cause seizures and should not be used internally. Avoid hyssop products during pregnancy and breastfeeding, and check with your pharmacist or doctor before using it.

Hyssopus officinalis · Lamiaceae · Above-ground parts (leaves, flowers, and stems) and the essential oil · Tea, capsules, tablets, tincture, essential oil

An interaction check asks whether these two react with each other — it does not ask whether Hyssop is a good idea for someone in your situation. Here is what our Hyssop record says about it on its own.

Hyssop: dosing

There is no well-established standardized dose for hyssop. Traditional use most often involves a tea made from a small amount of the dried herb steeped in hot water. Capsule and tablet products vary widely in strength.If you use a commercial product, follow the directions on the label and do not exceed them. Do not take the essential oil internally.

From our Hyssop monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hyssop monograph & all interactions
Medication

About Naproxen

What Is Naproxen Used For?

Brand names: Naprosyn, Naprelan, Anaprox, Anaprox DS, Naproxyn, Navalbine, Naproxen, Naprosyn EC, Napro-Na, Aleve, Arthroxen, Synflex, EC-Naprosyn

Naproxen tablets, naproxen sodium tablets, and naproxen oral suspension are used to relieve the signs and symptoms of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and polyarticular juvenile idiopathic arthritis. They are also used for tendonitis, bursitis, and acute gout, and for managing pain and primary dysmenorrhea (menstrual cramps).

Naproxen Sodium Controlled-Release Tablets are indicated for the same conditions plus the relief of mild to moderate pain. Several over-the-counter naproxen sodium products are indicated for the temporary relief of minor aches and pains from headache, backache, muscular aches, toothache, menstrual cramps, minor arthritis pain, and the common cold, and to temporarily reduce fever.

Most-Reported Side Effects for Naproxen

From FAERS, the FDA’s public side-effect reporting system (165,062 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 13,047 reports
Nausea 12,185 reports
Arthralgia 11,086 reports
Headache 10,504 reports
Diarrhea 9,841 reports
See full Naproxen drug information
Keep checking

Other Drugs & Hyssop

Browse every other medication we’ve checked against Hyssop — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Hyssop against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Hyssop list.

See the full Hyssop interactions page
See every supplement checked against Naproxen, ranked by severity
Evidence & sources

Hyssop References

The 1 references that drive our Hyssop monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hyssop and Naproxen Together: Common Questions

Is it safe to take Hyssop with Naproxen?
We do not list a known interaction between Hyssop and Naproxen. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Hyssop and Naproxen used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Hyssop in each. That is a conversation for your prescriber, especially if Naproxen is being adjusted to a target.
Does Naproxen interact with any supplements?
Yes. Naproxen has documented interactions with 311 supplements in our database — Hyssop is not one of them. The Naproxen interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hyssop monograph Uses, safety profile, and every drug interaction in one place Naproxen drug information The full plain-English guide to this medication Naproxen supplement interactions Every supplement checked against Naproxen, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Naproxen and Hyssop?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.