Drug & supplement interaction

Ignatius Bean + Granisetron

Granisetron brand names: Kytril, Sustol.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Ignatius Bean and Granisetron in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Granisetron states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Ignatius Bean and Granisetron

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Granisetron and Ignatius Bean in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Ignatius Bean at all — not against Granisetron, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ignatius Bean safety at a glance

Ignatius Bean overall Avoid The seed contains strychnine and brucine and is poisonous if taken in crude form.
Pregnancy Unsafe When used orally due to toxic effects. Read the full pregnancy detail
Breastfeeding Unsafe When used orally due to toxic effects. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Granisetron and Ignatius Bean? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Ignatius Bean and Granisetron May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Shortness of breath Worth acting on Additional detail

    Ignatius Bean

    “Orally, Ignatius bean is generally regarded as unsafe for use. Any benefits of therapy may not outweigh the risk of toxicity. Ignatius bean 30-50 mg, which contains approximately 5 mg of strychnine, can cause restlessness, anxiety, heightened sense perception, enhanced reflexes, equilibrium disorders, painful back and neck stiffness, twitching, spasms of jaw and neck muscles, myoglobinuric renal failure, rhabdomyolys…”

    Ignatius Bean · Natural Medicines adverse-effect record, reported in anxiety.

    4 sources cited
    1. 55854. Ellenhorn M. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. Baltimore, MD: Williams & Wilkins, 1997.
    2. 17. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
    3. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    4. 505. Hardman JG, Limbird LL, Molinoff PB, eds. Goodman and Gillman's The Pharmacological Basis of Therapeutics, 9th ed. New York, NY: McGraw-Hill, 1996.

    “Orally, Ignatius bean 30-50 mg, which contains approximately 5 mg of strychnine, has been reported to cause respiratory acidosis and difficulty breathing due to respiratory spasms.”

    Ignatius Bean · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 55854. Ellenhorn M. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. Baltimore, MD: Williams & Wilkins, 1997.

    Granisetron

    Listed in the ADVERSE REACTIONS section of the FDA label for Granisetron. Read the label on DailyMed ›

  • Anxiety or restlessness Additional detail

    Ignatius Bean

    “Orally, Ignatius bean 30-50 mg, which contains approximately 5 mg of strychnine, has been reported to cause restlessness, anxiety, heightened sense perception, enhanced reflexes, and twitching. It has also been reported to cause seizures within 15 minutes of ingestion.”

    Ignatius Bean · Natural Medicines adverse-effect record, reported in anxiety.

    4 sources cited
    1. 55854. Ellenhorn M. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. Baltimore, MD: Williams & Wilkins, 1997.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    3. 505. Hardman JG, Limbird LL, Molinoff PB, eds. Goodman and Gillman's The Pharmacological Basis of Therapeutics, 9th ed. New York, NY: McGraw-Hill, 1996.
    4. 17. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.

    Granisetron

    Listed in the ADVERSE REACTIONS section of the FDA label for Granisetron. Read the label on DailyMed ›

Reported for Ignatius Bean but not commonly for Granisetron: severe muscle breakdown, kidney problems, liver problems and seizures.

Effects for Granisetron come from the ADVERSE REACTIONS section of its FDA label; effects for Ignatius Bean come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Ignatius Bean in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When used orally due to toxic effects.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Granisetron Products Have a Food Rule — Ignatius Bean Should Not Break It

At least one FDA label for a product containing Granisetron says to take it on an empty stomach. Most supplements — Ignatius Bean included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Granisetron on its own and move Ignatius Bean to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Granisetron products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Recommended Dosage ( 2.2 ): The recommended dosage in adults is 10 mg administered as a single subcutaneous injection at least 30 minutes before the start of emetogenic chemotherapy on Day 1.

From the Dosage and Administration section of the FDA label we read for Granisetron — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Ignatius Bean or Granisetron

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Ignatius Bean or Granisetron, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Granisetron

This page covers Ignatius Bean only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Granisetron page lists 38 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Lithium (major), 5-htp (moderate), Acetyl-l-carnitine (moderate) and Ayahuasca (moderate).

By severity: 2 major · 25 moderate · 11 minor.

From our pharmacist’s overview on the Granisetron page

“Granisetron (Kytril, Sustol) blocks serotonin signals to stop nausea from chemotherapy and surgery, and this is a list that warrants real caution before you add a supplement to it. Most of the entries raise serotonin themselves, and stacking them on a serotonin-acting drug can push toward serotonin syndrome, a dangerous overload of tha…”

Reviewed by 2 · Jul 18, 2026

Open the Granisetron interaction page

One more smart check

Taking Ignatius Bean as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Ignatius Bean, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ignatius Bean. Even though Ignatius Bean itself has no known interaction with Granisetron, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ignatius Bean and Granisetron Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ignatius Bean
Steady interest

#772 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Granisetron
Steady interest

#2,677 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ignatius Bean reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Ignatius Bean and Granisetron records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ignatius Bean

What is Ignatius Bean?

Ignatius Bean
  • Grief, sadness, and emotional upset (homeopathic use)
  • Anxiety and stress (homeopathic use)
  • Mood swings
  • Digestive complaints (traditional use)
  • Historically used as a stimulant or for paralysis

Ignatius bean is a seed that naturally contains strychnine and brucine, which are highly toxic poisons. The raw seed or crude extracts should never be taken because even small amounts can cause dangerous muscle spasms and death. Today it is mainly seen in highly diluted homeopathic products (Ignatia), and you should talk to a pharmacist or doctor before using anything made from this plant.

Strychnos ignatii · Loganiaceae · Seed (the dried ripe seed, called the bean) · Homeopathic pellets and dilutions (Ignatia amara); raw seed is not used as a regular supplement

An interaction check asks whether these two react with each other — it does not ask whether Ignatius Bean is a good idea for someone in your situation. Here is what our Ignatius Bean record says about it on its own.

Ignatius Bean: dosing

There is no safe established dose of crude Ignatius bean. Because the seed contains strychnine, taking measured amounts of the raw plant is dangerous and is not recommended under any circumstances.Homeopathic Ignatia products come in their own dilutions and pellet strengths, with directions on the label.

From our Ignatius Bean monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ignatius Bean monograph & all interactions
Medication

About Granisetron

What Is Granisetron Used For?

Brand names: Kytril, Sustol

Granisetron is used to prevent nausea and vomiting linked to emetogenic (nausea-causing) cancer chemotherapy — including high-dose cisplatin — and radiation therapy, including total body irradiation and fractionated abdominal radiation. Granisetron hydrochloride tablets and Granisol oral solution are approved for both the chemotherapy and radiation indications. Sancuso skin patch is approved for prevention of nausea and vomiting in adults receiving moderately and/or highly emetogenic chemotherapy regimens of up to 5 consecutive days.

Granisetron hydrochloride injection (intravenous) is also used to prevent and treat postoperative nausea and vomiting in adults. Sustol (subcutaneous injection) is used in combination with other anti-nausea medicines in adults specifically for the prevention of acute and delayed nausea and vomiting associated with moderately emetogenic chemotherapy or anthracycline and cyclophosphamide combination chemotherapy regimens.

See full Granisetron drug information
Keep checking

Other Drugs & Ignatius Bean

Browse every other medication we’ve checked against Ignatius Bean — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Ignatius Bean against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Ignatius Bean list.

See the full Ignatius Bean interactions page
See every supplement checked against Granisetron, ranked by severity
Evidence & sources

Ignatius Bean References

The 6 references that drive our Ignatius Bean monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Hardman JG, Limbird LL, Molinoff PB, eds. Goodman and Gillman's The Pharmacological Basis of Therapeutics, 9th ed. New York, NY: McGraw-Hill, 1996.
  4. Hardman J, Limbird L. Goodman and Gillman's The Pharmacological Basis of Therapeutics, 9th ed. New York, NY: McGraw-Hill, 1996.
  5. Ellenhorn M. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. Baltimore, MD: Williams & Wilkins, 1997.
  6. Gruenwald J. PDR for Herbal Medicines. 1st ed ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ignatius Bean and Granisetron Together: Common Questions

Is it safe to take Ignatius Bean with Granisetron?
We do not list a known interaction between Ignatius Bean and Granisetron. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Ignatius Bean and Granisetron have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Ignatius Bean and Granisetron at the same time of day?
At least one FDA label for a product containing Granisetron says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Granisetron on its own and move Ignatius Bean to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Does Granisetron interact with any supplements?
Yes. Granisetron has documented interactions with 38 supplements in our database — Ignatius Bean is not one of them. The Granisetron interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ignatius Bean monograph Uses, safety profile, and every drug interaction in one place Granisetron drug information The full plain-English guide to this medication Granisetron supplement interactions Every supplement checked against Granisetron, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Granisetron and Ignatius Bean?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.