Drug & supplement interaction

Irvingia Gabonensis + Ranolazine

Ranolazine brand names: Ranexa, Aspruzyo.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Irvingia Gabonensis and Ranolazine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Irvingia Gabonensis and Ranolazine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ranolazine and Irvingia Gabonensis in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Irvingia Gabonensis safety at a glance

Irvingia Gabonensi... overall Use caution Generally tolerated short-term in studies, but long-term safety and product quality are not well established.
Pregnancy Avoid Not enough safety data, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety information is available while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ranolazine and Irvingia Gabonensis? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ranolazine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ranolazine is filed under 5 classifications — including cytochrome p450 2d6 (cyp2d6) inhibitors, qt interval-prolonging drugs, p-glycoprotein substrates. Irvingia Gabonensis has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and testosterone (moderate) — and none of Ranolazine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Irvingia Gabonensis Does Interact With Other Medications

Irvingia Gabonensis has 94 moderate known drug interactions in our database — Ranolazine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 94 No known interaction 2,736 (incl. Ranolazine)
Taking anything else?

Check Another of Your Medications Against Irvingia Gabonensis

Covers the 2,830 medications we’ve checked against Irvingia Gabonensis. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Irvingia Gabonensis and Ranolazine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach upset / Tiredness Additional detail

    Irvingia Gabonensis

    “One case of acute hepatitis secondary to Irvingia gabonensis has been reported. A 45-year old male with a ten-day history of Irvingia gabonensis supplementation, at a dose of 350 mg of seed extract twice daily for body fat reduction, was admitted with jaundice, abdominal discomfort, and new onset malaise. His complaints began four days after starting Irvingia gabonensis supplementation.”

    Irvingia Gabonensis · Natural Medicines adverse-effect record, reported in alcohol-related liver disease.

    1 source cited
    1. 92824. Kilinçalp S, Basar O, Coban S, Yüksel I. Irvingia gabonensis (African mango): innocent magic formula? Acta Gastroenterol Belg 2014;77(1):75-6.

    Ranolazine

    Listed in the ADVERSE REACTIONS section of the FDA label for Ranolazine. Read the label on DailyMed ›

  • Headache Additional detail

    Irvingia Gabonensis

    “Headache and insomnia have been reported in patients taking Irvingia gabonensis alone or in conjunction with Cissus quadrangularis for periods of 10 weeks. Similar events were observed in control groups.”

    Irvingia Gabonensis · Natural Medicines adverse-effect record, reported in cluster headache.

    2 sources cited
    1. 16457. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
    2. 17070. Ngondi JL, Etoundi BC, Nyangono CB, et al. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controll

    Ranolazine

    Listed in the ADVERSE REACTIONS section of the FDA label for Ranolazine. Read the label on DailyMed ›

  • Nausea Additional detail

    Irvingia Gabonensis

    “Flatulence has been reported following 10 weeks of supplementation with Irvingia gabonensis alone or in combination with Cissus quadrangularis. Similar events were observed in controls. Mild nausea has also been reported following the administration of Irvingia gabonensis 0.3-4 grams daily for up to 12 weeks; however, some of these symptoms were alleviated by the addition of milk to the test preparation.”

    Irvingia Gabonensis · Natural Medicines adverse-effect record, reported in flatulence.

    4 sources cited
    1. 17070. Ngondi JL, Etoundi BC, Nyangono CB, et al. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controll
    2. 16457. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
    3. 61589. Adamson, I., Okafor, C., and Abu-Bakare, A. A supplement of Dikanut (Irvingia gabonesis) improves treatment of type II diabetics. West Afr.J.Med. 1990;9(2):108-115.
    4. 112220. Nonsa-Ard R, Aneknan P, Tong-Un T, Honsawek S, Leelayuwat N. Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals. Nutrients 2022;14(21):4646. PubMed

    Ranolazine

    Listed in the ADVERSE REACTIONS section of the FDA label for Ranolazine. Read the label on DailyMed ›

Reported for Irvingia Gabonensis but not commonly for Ranolazine: bloating or gas, liver problems, trouble sleeping and yellowing of the skin or eyes.

Effects for Ranolazine come from the ADVERSE REACTIONS section of its FDA label; effects for Irvingia Gabonensis come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 10,189 voluntary FDA FAERS reports for Ranolazine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Ranolazine

This page covers Irvingia Gabonensis only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ranolazine page lists 153 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 8 major · 109 moderate · 36 minor.

From our pharmacist’s overview on the Ranolazine page

“Ranolazine (Ranexa, Aspruzyo), a medicine for chronic chest pain, depends heavily on one liver enzyme, CYP3A4, and that is where most of its supplement trouble sits. Grapefruit can push ranolazine levels up, St.”

Reviewed by 2 · Jul 18, 2026

Open the Ranolazine interaction page

One more smart check

Taking Irvingia Gabonensis as Part of a Dietary Supplement Product? Check It for Interactions

We hold 406 real supplement products containing Irvingia Gabonensis, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Irvingia Gabonensis. Even though Irvingia Gabonensis itself has no known interaction with Ranolazine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Irvingia Gabonensis and Ranolazine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Irvingia Gabonensis
Top 25%

#288 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ranolazine
Top half

#1,148 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Irvingia Gabonensis reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Irvingia Gabonensis and Ranolazine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Irvingia Gabonensis

What is Irvingia Gabonensis?

Irvingia Gabonensis
  • Weight loss
  • Appetite control
  • Cholesterol support
  • Blood sugar support
  • Metabolism support

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benefits, but the research is limited and low-quality, so the true effect is uncertain. Talk with your pharmacist or doctor before using it, and do not rely on it in place of proven diet and lifestyle changes.

Irvingia gabonensis · Irvingiaceae · Seed (kernel, also called dika nut); seed extract · Capsules, tablets, powder, standardized seed extract

An interaction check asks whether these two react with each other — it does not ask whether Irvingia Gabonensis is a good idea for someone in your situation. Here is what our Irvingia Gabonensis record says about it on its own.

Irvingia Gabonensis: dosing

There is no officially established or standardized dose for Irvingia gabonensis. Studies have used different seed extracts and amounts, so it is hard to recommend one specific dose.If you choose to try it, follow the directions on the product label and do not exceed them.

From our Irvingia Gabonensis monograph — the full record covers uses, side effects and every documented interaction.

Read the full Irvingia Gabonensis monograph & all interactions
Medication

About Ranolazine

What Is Ranolazine Used For?

Brand names: Ranexa, Aspruzyo

Ranolazine treats chronic angina — the recurring chest pain or pressure that happens when the heart isn't getting enough blood and oxygen. It is used when other angina medicines aren't enough on their own.

Both the extended-release tablet (sold as Ranexa and generic ranolazine) and the oral powder form (sold as Aspruzyo Sprinkle) are approved for this use. Ranolazine can be combined with other heart medicines such as beta-blockers, nitrates, calcium channel blockers, anti-platelet drugs, statins, ACE inhibitors, and angiotensin receptor blockers.

Most-Reported Side Effects for Ranolazine

From FAERS, the FDA’s public side-effect reporting system (10,376 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Myocardial infarction 646 reports
Chest pain 614 reports
Angina pectoris 595 reports
Stent placement 582 reports
Dyspnea 439 reports
See full Ranolazine drug information
Keep checking

Other Drugs & Irvingia Gabonensis

Browse every other medication we’ve checked against Irvingia Gabonensis — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
94Moderate
0Minor
2,735No known interaction
94 Moderate 2,735 No interaction
Moderate

94 interactions

Showing 60 of 94 moderate interactions — see all 94 on the Irvingia Gabonensis page.

No interaction 2,735 drugs checked — show the list

We also checked Irvingia Gabonensis against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,735 medications checked with no known interaction — see the full Irvingia Gabonensis list.

See the full Irvingia Gabonensis interactions page
See every supplement checked against Ranolazine, ranked by severity
Evidence & sources

Irvingia Gabonensis References

The 7 references that drive our Irvingia Gabonensis monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  2. Ngondi JL, Etoundi BC, Nyangono CB, et al. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controll
  3. Adamson, I., Okafor, C., and Abu-Bakare, A. A supplement of Dikanut (Irvingia gabonesis) improves treatment of type II diabetics. West Afr.J.Med. 1990;9(2):108-115.
  4. Adamson, I., Okafor, C., and Abu-Bakare, A. Erythrocyte membrane ATPases in diabetes: effect of dikanut (Irvingia gabonensis). Enzyme 1986;36(3):212-215. PubMed
  5. Wolfe OA, Ijeoma UF. Effects of aqueous extracts of Irvingia gabonensis seeds on the hormonal parameters of male guinea pigs. Asian Pacific Journal of Tropical Medicine. 2010;3(3):200-204. DOI
  6. Kilinçalp S, Basar O, Coban S, Yüksel I. Irvingia gabonensis (African mango): innocent magic formula? Acta Gastroenterol Belg 2014;77(1):75-6.
  7. Nonsa-Ard R, Aneknan P, Tong-Un T, Honsawek S, Leelayuwat N. Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals. Nutrients 2022;14(21):4646. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Irvingia Gabonensis and Ranolazine Together: Common Questions

Is it safe to take Irvingia Gabonensis with Ranolazine?
We do not list a known interaction between Irvingia Gabonensis and Ranolazine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Irvingia Gabonensis and Ranolazine have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Irvingia Gabonensis and Ranolazine combination checked?
Interactions in our licensed database are recorded against drug classes. Ranolazine is filed under 5 classifications, and Irvingia Gabonensis has documented interactions with 2 drug classes — none of Ranolazine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Irvingia Gabonensis interact with any other medications?
Yes. Irvingia Gabonensis has 94 documented drug interactions in our database — Ranolazine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ranolazine interact with any supplements?
Yes. Ranolazine has documented interactions with 153 supplements in our database — Irvingia Gabonensis is not one of them. The Ranolazine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Irvingia Gabonensis monograph Uses, safety profile, and every drug interaction in one place Ranolazine drug information The full plain-English guide to this medication Ranolazine supplement interactions Every supplement checked against Ranolazine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ranolazine and Irvingia Gabonensis?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.