Drug & supplement interaction

Japanese Apricot + Aspirin, Codeine Phosphate

Aspirin, Codeine Phosphate brand name: Aspirin w/ Codeine.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Japanese Apricot has a moderate interaction with Aspirin, Codeine Phosphate. Some constituents of Japanese apricot flower extract might have antiplatelet properties.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Japanese Apricot and Aspirin, Codeine Phosphate

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Aspirin, Codeine Phosphate

Aspirin, Codeine Phosphate falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Japanese Apricot interacts with.

Some constituents of Japanese apricot flower extract might have antiplatelet properties. Theoretically, combining Japanese flower extract with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising or bleeding. Some of these drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, indomethacin (Indocin), ticlopidine (Ticlid), warfarin (Coumadin), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Your medicine pairs aspirin with codeine for pain. The aspirin half is what matters here. Aspirin already thins the blood a little by keeping platelets from clumping. Some lab studies suggest that compounds in Japanese Apricot flower extract may also have a mild platelet-slowing effect. Put the two together and, in theory, you could bruise more easily or have a harder time stopping minor bleeding.

I want to be honest about the strength of this: it comes from test-tube and animal research, not from people, so it is a possible concern rather than a proven one. Eating umeboshi or apricot as food is very unlikely to matter. Concentrated extracts are where I would pause. Before adding a Japanese Apricot supplement, check with your pharmacist or doctor, especially if you notice unusual bruising, nosebleeds, or bleeding gums.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Matsuda H, Morikawa T, Ishiwada T, et al. Medicinal flowers. VIII. Radical scavenging constituents from the flowers of Prunus mume: structure of prunose III. Chem Pharm Bull (Tokyo) 2003;51:440-3.. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Japanese Apricot Also Interacts With Other Medications

Japanese Apricot has 207 moderate known drug interactions in our database — the Aspirin, Codeine Phosphate one above is one of them. If you take anything else, check it against the full list below.

Moderate 207 No known interaction 2,623 (incl. Aspirin, Codeine Phosphate)
Taking anything else?

Check Another of Your Medications Against Japanese Apricot

Covers the 2,830 medications we’ve checked against Japanese Apricot. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Aspirin, Codeine Phosphate

This page covers Japanese Apricot only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Codeine Phosphate page lists 327 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).

By severity: 11 major · 281 moderate · 35 minor.

From our pharmacist’s overview on the Aspirin, Codeine Phosphate page

“Aspirin with codeine pairs a blood-thinning pain reliever with an opioid, and the 327 ingredients on this page reflect both halves, so this combination deserves genuine care before any supplement joins it. Most of the list, over 200 ingredients, can add to aspirin's effect on platelets and raise bleeding risk.”

Reviewed by 2 · Jul 18, 2026

Open the Aspirin, Codeine Phosphate interaction page

One more smart check

Taking Japanese Apricot as Part of a Dietary Supplement Product? Check It for Interactions

We hold 12 real supplement products containing Japanese Apricot, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Japanese Apricot. Your product may carry other ingredients that interact with Aspirin, Codeine Phosphate too, on top of Japanese Apricot — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Japanese Apricot and Aspirin, Codeine Phosphate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Japanese Apricot
Top half

#563 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aspirin, Codeine Phosphate
Top half

#775 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Japanese Apricot

What is Japanese Apricot?

  • Digestive upset
  • Fatigue and general wellness
  • Sore throat and cough
  • Antimicrobial support
  • Liver and detox support (traditional)

Japanese Apricot (Prunus mume) is a tart fruit used widely in East Asian foods and traditional medicine, often as pickled umeboshi or a concentrated extract. It has a long history of culinary and folk use, but high-quality human studies are limited, so most health claims remain unproven. The processed fruit is generally well tolerated as a food, but talk to a pharmacist or doctor before using concentrated supplements.

Read the full Japanese Apricot monograph & all interactions
Keep checking

Other Drugs & Japanese Apricot

Browse every other medication we’ve checked against Japanese Apricot — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
207Moderate
0Minor
2,622No known interaction
207 Moderate 2,622 No interaction
Moderate

207 interactions

Showing 60 of 207 moderate interactions — see all 207 on the Japanese Apricot page.

No interaction 2,622 drugs checked — show the list

We also checked Japanese Apricot against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,622 medications checked with no known interaction — see the full Japanese Apricot list.

See the full Japanese Apricot interactions page
See every supplement checked against Aspirin, Codeine Phosphate, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Japanese Apricot monograph › Uses, safety, and every drug interaction in one place Aspirin, Codeine Phosphate supplement interactions › Every supplement checked against Aspirin, Codeine Phosphate, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Japanese Apricot and Aspirin, Codeine Phosphate Together: Common Questions

Can you take Japanese Apricot with Aspirin, Codeine Phosphate?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Japanese Apricot and Aspirin, Codeine Phosphate interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Aspirin, Codeine Phosphate and Japanese Apricot?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.