Medication interaction hub

What Supplements Interact with Aspirin, Codeine Phosphate?

Aspirin, Codeine Phosphate brand name: Aspirin w/ Codeine. Every interaction below applies to the brands too.

327 Interactions 11 Major 281 Moderate 35 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Aspirin, Codeine Phosphate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Aspirin, Codeine Phosphate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Aspirin with codeine pairs a blood-thinning pain reliever with an opioid, and the 327 ingredients on this page reflect both halves, so this combination deserves genuine care before any supplement joins it. Most of the list, over 200 ingredients, can add to aspirin's effect on platelets and raise bleeding risk. Another 78 deepen the codeine side, piling on drowsiness and, at the extreme, slowed breathing. Alcohol, whether beer or wine, sits among the 11 major-rated entries for exactly that reason, and so does kava.

The 281 moderate entries are broader. Sixty herbs can interfere with the liver enzyme that turns codeine into its active painkiller, and a smaller cluster of fibers and charcoals can blunt absorption of anything swallowed close to a dose, so keep those well separated. The 35 minor listings matter least; the 11 majors, mostly bleeding and sedation risks, are where a careful read pays off.

— , Clinical Pharmacist · July 18, 2026

Major 11 Moderate 281 Minor 35 No known interaction 1,125

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Aspirin, Codeine Phosphate: Top Interactions at a Glance

The Aspirin, Codeine Phosphate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 327 interacting ingredients — plus 1,125 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Aspirin, Codeine Phosphate Combinations Today

The Aspirin, Codeine Phosphate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Niacin + Aspirin, Codeine Phosphatei

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Terminalia + Aspirin, Codeine Phosphatei

Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.

Read the full interaction Major Likelihood Probable L-tryptophan + Aspirin, Codeine Phosphatei

Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.

Read the full interaction Moderate Likelihood Possible Marsh Labrador Tea + Aspirin, Codeine Phosphatei

Marsh Labrador tea can potentiate effects of barbiturates and alcohol.

Read the full interaction Moderate Likelihood Possible Cod Liver Oil + Aspirin, Codeine Phosphatei

Theoretically, cod liver oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Major Likelihood Likely Beer + Aspirin, Codeine Phosphatei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Aspirin, Codeine Phosphate

All 1,452 ingredients in our database, ranked by severity — 327 with a Aspirin, Codeine Phosphate interaction on file and 1,125 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Aspirin, Codeine Phosphate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Niacin with Aspirin, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.

Full Niacin + Aspirin, Codeine Phosphate answer

Can you take Terminalia with Aspirin, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.

Full Terminalia + Aspirin, Codeine Phosphate answer

Can you take L-tryptophan with Aspirin, Codeine Phosphate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.

Full L-tryptophan + Aspirin, Codeine Phosphate answer

Can you take Marsh Labrador Tea with Aspirin, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Marsh Labrador tea can potentiate effects of barbiturates and alcohol.

Full Marsh Labrador Tea + Aspirin, Codeine Phosphate answer

Can you take Cod Liver Oil with Aspirin, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cod liver oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Cod Liver Oil + Aspirin, Codeine Phosphate answer

Can you take Dong Quai with Aspirin, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, dong quai may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs; however, research is conflict...

Full Dong Quai + Aspirin, Codeine Phosphate answer

Can you take Eicosapentaenoic Acid (epa) with Aspirin, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, EPA may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Eicosapentaenoic Acid (epa) + Aspirin, Codeine Phosphate answer

Can you take Elecampane with Aspirin, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.

Full Elecampane + Aspirin, Codeine Phosphate answer

Can you take Eleuthero with Aspirin, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drug...

Full Eleuthero + Aspirin, Codeine Phosphate answer

Can you take English Ivy with Aspirin, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Full English Ivy + Aspirin, Codeine Phosphate answer

Can you take European Barberry with Aspirin, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Full European Barberry + Aspirin, Codeine Phosphate answer

Can you take Evening Primrose with Aspirin, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, evening primrose oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Evening Primrose + Aspirin, Codeine Phosphate answer

Can you take Evodia with Aspirin, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking evodia with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.

Full Evodia + Aspirin, Codeine Phosphate answer

Can you take False Unicorn with Aspirin, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, false unicorn extract inhibits cytochrome P450 2D6 (CYP2D6) activity.

Full False Unicorn + Aspirin, Codeine Phosphate answer

Can you take Fasting with Aspirin, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Fasting may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Fasting + Aspirin, Codeine Phosphate answer

Can you take Fennel with Aspirin, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Full Fennel + Aspirin, Codeine Phosphate answer

Can you take Fever Bark with Aspirin, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fever bark might increase the levels and clinical effects of CYP2D6 substrates.

Full Fever Bark + Aspirin, Codeine Phosphate answer

Can you take Feverfew with Aspirin, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP2D6.

Full Feverfew + Aspirin, Codeine Phosphate answer

Can you take Flaxseed with Aspirin, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of b...

Full Flaxseed + Aspirin, Codeine Phosphate answer

Can you take Flaxseed Oil with Aspirin, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk...

Full Flaxseed Oil + Aspirin, Codeine Phosphate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Aspirin, Codeine Phosphate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Aspirin, Codeine Phosphate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Aspirin, Codeine Phosphate sits in 12 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate through this category.

Aspirin 22 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

22 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate through this category.

Nonsteroidal Anti-Inflammatory Drugs (Nsaids) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate through this category.

Codeine 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Aspirin, Codeine Phosphate through this category.

Related: does Aspirin, Codeine Phosphate deplete any nutrients?

Aspirin, Codeine Phosphate has 4 reported nutrient associations in the research literature — see the Aspirin, Codeine Phosphate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Aspirin, Codeine Phosphate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Aspirin, Codeine Phosphate.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Products that contain Aspirin, Codeine Phosphate-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Aspirin, Codeine Phosphate.

Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur
Pharmacist Counseling Corner

Aspirin, Codeine Phosphate & Supplements: Common Questions

What supplements interact with Aspirin, Codeine Phosphate?
Our database currently documents 327 ingredients with a known Aspirin, Codeine Phosphate interaction (11 major, 281 moderate, 35 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 327. The highest-ranked right now: Beer, Siberian Cocklebur, Wine.
Which Aspirin, Codeine Phosphate supplement interactions are the most serious?
Focus on the major group: Beer, Siberian Cocklebur, Wine, 1,4-butanediol and Activated Charcoal, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Aspirin, Codeine Phosphate?
Plenty of supplements coexist fine with Aspirin, Codeine Phosphate; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Aspirin w/ Codeine have the same supplement interactions as Aspirin, Codeine Phosphate?
Yes — Aspirin w/ Codeine all contain Aspirin, Codeine Phosphate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Aspirin, Codeine Phosphate deplete any vitamins or nutrients?
It might — Aspirin, Codeine Phosphate has 4 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Aspirin, Codeine Phosphate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Aspirin, Codeine Phosphate and my other medications?
This page covers Aspirin, Codeine Phosphate against supplements and herbal ingredients. Checking Aspirin, Codeine Phosphate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.