Drug & supplement interaction

Caprylic Acid + Aspirin, Codeine Phosphate

Aspirin, Codeine Phosphate brand name: Aspirin w/ Codeine.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Caprylic Acid has a moderate interaction with Aspirin, Codeine Phosphate. Theoretically, caprylic acid might increase plasma concentrations of NSAIDs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Caprylic Acid and Aspirin, Codeine Phosphate

Here is the interaction we found between these two, with the evidence behind it.

Moderate

NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs)

Why this applies to Aspirin, Codeine Phosphate

Aspirin, Codeine Phosphate falls under NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) — the group Caprylic Acid interacts with.

Theoretically, caprylic acid might increase plasma concentrations of NSAIDs.
In vitro research suggests that caprylic acid might displace NSAIDs from binding sites on albumin. This effect has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Your combo pill pairs aspirin with codeine. The interaction we have on file is really about the aspirin part. Aspirin rides through your blood by clinging to a protein called albumin. In test-tube studies, caprylic acid (a fat from coconut oil) seems to bump aspirin off those protein parking spots, which could leave a little more free aspirin floating around. In theory that might nudge up aspirin-type effects like stomach upset, heartburn, or easier bruising and bleeding.

The key word here is theory. This has only been seen in the lab, never confirmed in people, and food amounts of caprylic acid are very unlikely to matter. Still, if you take concentrated caprylic acid supplements, mention it to your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Massolini G, Aubry AF, McGann A, Wainer IW. Determination of the magnitude and enantioselectivity of ligand binding to rat and rabbit serum albumins using immobilized-protein high performance liquid chromatography stationary phases. Biochem Pharmacol 1993 PubMed
  2. Hayball PF, Holman JW, Nation RL. Influence of octanoic acid on the reversible protein binding of ketorolac enantiomers to human serum albumin (HSA): comparative liquid chromatographic studies using a HSA chiral stationary phase. J Chromatogr B Biomed App PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Caprylic Acid Also Interacts With Other Medications

Caprylic Acid has 261 moderate known drug interactions in our database — the Aspirin, Codeine Phosphate one above is one of them. If you take anything else, check it against the full list below.

Moderate 261 No known interaction 2,569 (incl. Aspirin, Codeine Phosphate)
Taking anything else?

Check Another of Your Medications Against Caprylic Acid

Covers the 2,830 medications we’ve checked against Caprylic Acid. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Aspirin, Codeine Phosphate

This page covers Caprylic Acid only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Codeine Phosphate page lists 327 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).

By severity: 11 major · 281 moderate · 35 minor.

From our pharmacist’s overview on the Aspirin, Codeine Phosphate page

“Aspirin with codeine pairs a blood-thinning pain reliever with an opioid, and the 327 ingredients on this page reflect both halves, so this combination deserves genuine care before any supplement joins it. Most of the list, over 200 ingredients, can add to aspirin's effect on platelets and raise bleeding risk.”

Reviewed by 2 · Jul 18, 2026

Open the Aspirin, Codeine Phosphate interaction page

One more smart check

Taking Caprylic Acid as Part of a Dietary Supplement Product? Check It for Interactions

We hold 514 real supplement products containing Caprylic Acid, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Caprylic Acid. Your product may carry other ingredients that interact with Aspirin, Codeine Phosphate too, on top of Caprylic Acid — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Caprylic Acid and Aspirin, Codeine Phosphate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Caprylic Acid
Top 25%

#311 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aspirin, Codeine Phosphate
Top half

#876 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Caprylic Acid

What is Caprylic Acid?

Caprylic Acid
  • Candida and yeast overgrowth
  • Gut health support
  • Antimicrobial
  • Digestive health
  • Part of ketogenic diets

Caprylic acid is a medium-chain fatty acid found in coconut oil and palm kernel oil that is popularly used for yeast overgrowth and gut health. While laboratory studies show it has antimicrobial activity, strong human evidence for most supplement claims is limited. It is generally considered safe in food amounts, but talk with your pharmacist or doctor before using concentrated supplements.

Read the full Caprylic Acid monograph & all interactions
Keep checking

Other Drugs & Caprylic Acid

Browse every other medication we’ve checked against Caprylic Acid — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
261Moderate
0Minor
2,568No known interaction
261 Moderate 2,568 No interaction
Moderate

261 interactions

Showing 60 of 261 moderate interactions — see all 261 on the Caprylic Acid page.

No interaction 2,568 drugs checked — show the list

We also checked Caprylic Acid against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,568 medications checked with no known interaction — see the full Caprylic Acid list.

See the full Caprylic Acid interactions page
See every supplement checked against Aspirin, Codeine Phosphate, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Caprylic Acid monograph › Uses, safety, and every drug interaction in one place Aspirin, Codeine Phosphate supplement interactions › Every supplement checked against Aspirin, Codeine Phosphate, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Caprylic Acid and Aspirin, Codeine Phosphate Together: Common Questions

Can you take Caprylic Acid with Aspirin, Codeine Phosphate?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Caprylic Acid and Aspirin, Codeine Phosphate interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Aspirin, Codeine Phosphate and Caprylic Acid?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.