Drug & supplement interaction

Jewelweed + Calcifediol

Calcifediol brand name: Rayaldee.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Jewelweed and Calcifediol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Jewelweed and Calcifediol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Calcifediol and Jewelweed in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Jewelweed at all — not against Calcifediol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Jewelweed safety at a glance

Jewelweed overall Use caution Generally used on the skin with few reported problems, but it is not well studied and should not be taken by mouth without guidance.
Pregnancy Avoid There is not enough safety information, so avoid use during pregnancy unless your doctor approves.
Breastfeeding Avoid There is not enough safety information, so avoid use while breastfeeding unless your doctor approves.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Calcifediol and Jewelweed? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Calcifediol’s Own FDA Label Lists

This is not an interaction — none of it involves Jewelweed. These are the most notable effects listed in the ADVERSE REACTIONS section of Calcifediol’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 8 of them are worth acting on rather than waiting out — marked below.

  • High potassium Worth acting on
  • Heart failure Worth acting on
  • Kidney problems Worth acting on mentioned in 4.8% of FDA reports for Calcifediol
  • Anemia Worth acting on mentioned in 2.8% of FDA reports for Calcifediol
  • Shortness of breath Worth acting on mentioned in 3.0% of FDA reports for Calcifediol
  • Raised blood pressure Worth acting on
  • Bleeding or bruising Worth acting on
  • A higher chance of infection Worth acting on mentioned in 2.6% of FDA reports for Calcifediol
  • Cough
  • Constipation

From the ADVERSE REACTIONS section of the FDA label for Calcifediol. Read the label on DailyMed › Where a percentage is shown, it is the share of 2,421 voluntary FDA FAERS reports for Calcifediol that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Jewelweed’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Jewelweed side to compare — that is a limit of the record, not a statement that Jewelweed has no side effects.

Everything else you take

See Every Supplement That Interacts With Calcifediol

This page covers Jewelweed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Calcifediol page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Calcifediol page

“Most people taking calcifediol (Rayaldee) are managing chronic kidney disease and an overactive parathyroid, and that same group often takes supplements. This list deserves genuine respect.”

Reviewed by 2 · Jul 18, 2026

Open the Calcifediol interaction page

One more smart check

Taking Jewelweed as Part of a Dietary Supplement Product? Check It for Interactions

We hold 8 real supplement products containing Jewelweed, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Jewelweed. Even though Jewelweed itself has no known interaction with Calcifediol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Jewelweed and Calcifediol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jewelweed
Steady interest

#1,381 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Calcifediol
Steady interest

#2,172 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Jewelweed reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Jewelweed and Calcifediol records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Jewelweed

What is Jewelweed?

  • Poison ivy and poison oak rashes
  • Skin itching and irritation
  • Insect bites and stings
  • Nettle stings
  • Minor skin inflammation

Jewelweed is a wild plant traditionally rubbed on the skin to soothe poison ivy rashes, bug bites, and itching. Good scientific evidence is limited and mostly weak, so it should not replace proven treatments. It is generally used on the skin, and you should always check with a pharmacist or doctor before using it, especially during pregnancy or breastfeeding.

Impatiens capensis · Balsaminaceae · Stems, leaves, and the sap (juice) from the crushed plant · Fresh crushed plant, salves, soaps, lotions, sprays, frozen cubes, and tinctures

An interaction check asks whether these two react with each other — it does not ask whether Jewelweed is a good idea for someone in your situation. Here is what our Jewelweed record says about it on its own.

Jewelweed: dosing

There is no official or standardized dose for jewelweed. People traditionally crush the fresh stems and leaves and rub the juice directly on the affected skin, and many use commercial salves, soaps, or sprays.If you use a store-bought product, follow the directions on the label.

From our Jewelweed monograph — the full record covers uses, side effects and every documented interaction.

Read the full Jewelweed monograph & all interactions
Medication

About Calcifediol

What Is Calcifediol Used For?

Brand name: Rayaldee

Rayaldee (calcifediol extended-release capsule) is approved to treat secondary hyperparathyroidism — a condition where the parathyroid glands overproduce parathyroid hormone (PTH) — in adults who have stage 3 or 4 chronic kidney disease and vitamin D levels below 30 ng/mL.

Rayaldee is not approved for stage 5 chronic kidney disease or for people on dialysis (end-stage renal disease).

Most-Reported Side Effects for Calcifediol

From FAERS, the FDA’s public side-effect reporting system (2,421 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Acute kidney injury 116 reports
Nausea 76 reports
Dyspnea 72 reports
Anemia 68 reports
Pneumonia 64 reports
See full Calcifediol drug information
Keep checking

Other Drugs & Jewelweed

Browse every other medication we’ve checked against Jewelweed — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Jewelweed against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Jewelweed list.

See the full Jewelweed interactions page
See every supplement checked against Calcifediol, ranked by severity
Evidence & sources

Jewelweed References

The 3 references that drive our Jewelweed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Long, D., Ballentine, N. H., and Marks, J. G., Jr. Treatment of poison ivy/oak allergic contact dermatitis with an extract of jewelweed. Am J Contact Dermat. 1997;8(3):150-153. DOI
  2. Zink, B. J., Otten, E. J., Rosentha, M., and Singal, B. The effect of jewel week in preventing poison ivy. J Wilderness Medicine 1991;2:178-182.
  3. Abrams Motz V, Bowers CP, Mull Young L, Kinder DH. The effectiveness of jewelweed, Impatiens capensis, the related cultivar I. balsamina and the component, lawsone in preventing post poison ivy exposure contact dermatitis. J Ethnopharmacol 2012;143(1):314 PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Jewelweed and Calcifediol Together: Common Questions

Is it safe to take Jewelweed with Calcifediol?
We do not list a known interaction between Jewelweed and Calcifediol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Calcifediol interact with any supplements?
Yes. Calcifediol has documented interactions with 138 supplements in our database — Jewelweed is not one of them. The Calcifediol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Jewelweed monograph Uses, safety profile, and every drug interaction in one place Calcifediol drug information The full plain-English guide to this medication Calcifediol supplement interactions Every supplement checked against Calcifediol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Calcifediol and Jewelweed?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.