Karaya Gum - Vitrakvi (Larotrectinib) Interaction
Herbal: Karaya Gum
Also Known As: Bassora Tragacanth, Goma Karaya, Gomme Karaya, Gomme Kuteera, Gomme Sterculia, Gum Karaya, Gomme de Sterculia, Indian Tragacanth, Kadaya, Kadira, Karaya, Katila, Katira Gum, Kullo, Mucara, Sterculia, Sterculia Gum
Drug: Larotrectinib
Brand names:
Vitrakvi
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Larotrectinib is classified as belonging to the following category: Oral Drugs
Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption of drugs. To avoid changes in absorption, take karaya gum 30-60 minutes after oral medications.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Karaya Gum Overview
Karaya gum is a type of natural gum that is obtained from the sap of the Sterculia tree, which is native to India and parts of Asia. It is a highly viscous, water-soluble gum that is used in various industrial and food applications. Karaya gum has many unique properties, such as high stability, thickening ability, and emulsifying power, making it useful in a variety of industries. It is also commonly used as a natural laxative.
Larotrectinib Overview
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Larotrectinib is used to treat a certain type of solid tumors in adults, children, and infants 4 weeks of age and older that have spread to other parts of the body or cannot be treated successfully with surgery. This medication is used only if there are no other treatments available and the tumors have worsened after receiving other treatments. Larotrectinib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that tells the cancer cells to multiply. This may help slow the growth of tumors.
Karaya Gum - More Interactions
Karaya Gum interacts with 1987 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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