Drug & supplement interaction

Koch's Glycoside + Clomipramine

Clomipramine brand names: Anafranil, Anafranil SR.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Koch's Glycoside and Clomipramine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Clomipramine states a food rule worth keeping to.

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Interaction report

Koch's Glycoside and Clomipramine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Clomipramine and Koch's Glycoside in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Koch's Glycoside at all — not against Clomipramine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Koch's Glycoside safety at a glance

Koch's Glycoside overall Not established There is no reliable safety information for any product called Koch's Glycoside.
Pregnancy Avoid With no safety data available, avoid use during pregnancy.
Breastfeeding Avoid With no safety data available, avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Clomipramine and Koch's Glycoside? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Clomipramine’s Own FDA Label Lists

This is not an interaction — none of it involves Koch's Glycoside. These are the most notable effects listed in the ADVERSE REACTIONS section of Clomipramine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Loss of vision Worth acting on
  • A change in thyroid levels Worth acting on
  • Dependence or withdrawal symptoms Worth acting on
  • Thoughts of self-harm Worth acting on
  • Hearing loss Worth acting on
  • A bowel blockage Worth acting on
  • Pain or burning when passing urine Worth acting on
  • Muscle weakness Worth acting on
  • Memory problems Worth acting on
  • Dehydration Worth acting on

Showing the 10 most notable of 85 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Clomipramine. Read the label on DailyMed › Koch's Glycoside’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Koch's Glycoside side to compare — that is a limit of the record, not a statement that Koch's Glycoside has no side effects.

How to take them

Some Clomipramine Products Have a Food Rule — Koch's Glycoside Should Not Break It

At least one FDA label for a product containing Clomipramine says to take it with food. If you take Koch's Glycoside on an empty stomach out of habit, keep them separate — and take Clomipramine with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Clomipramine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

During initial titration, Anafranil should be given in divided doses with meals to reduce gastrointestinal side effects.

From the Dosage and Administration section of the FDA label we read for Clomipramine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Koch's Glycoside or Clomipramine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Koch's Glycoside or Clomipramine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Clomipramine

This page covers Koch's Glycoside only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Clomipramine page lists 236 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Henbane (major), Scopolia (major) and St. John's Wort (major).

By severity: 5 major · 179 moderate · 52 minor.

From our pharmacist’s overview on the Clomipramine page

“A tricyclic antidepressant used mostly for OCD, clomipramine (Anafranil) is unforgiving of shifts in its blood level, which is why its 236 supplement interactions deserve genuine wariness. Most of the list involves metabolism: herbs that speed up or slow down the liver enzymes handling clomipramine can drag its level too low or push it…”

Reviewed by 2 · Jul 18, 2026

Open the Clomipramine interaction page

How much people look this up

Where Koch's Glycoside and Clomipramine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Koch's Glycoside
Steady interest

#1,404 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Clomipramine
Steady interest

#1,933 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Koch's Glycoside is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Koch's Glycoside reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Koch's Glycoside and Clomipramine records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Koch's Glycoside

What is Koch's Glycoside?

"Koch's Glycoside" is not a recognized dietary supplement, herb, or established medical compound, and there is no reliable information available about its source, safety, or effects. The name may be a confusion with discredited historical "cancer cures" (such as William F. Koch's controversial "glyoxylide") rather than a true plant glycoside. Because nothing trustworthy is known about it, we cannot recommend using it, and you should speak with a pharmacist or doctor before trying any product sold under this name.

An interaction check asks whether these two react with each other — it does not ask whether Koch's Glycoside is a good idea for someone in your situation. Here is what our Koch's Glycoside record says about it on its own.

Koch's Glycoside: dosing

There is no established or safe dose for Koch's Glycoside. No standardized preparation exists, and no health authority provides dosing guidance for it.We cannot recommend any amount. If you are considering a product sold under this name, bring the actual label and ingredient list to a pharmacist or doctor so they can help you understand what you would actually be taking.

From our Koch's Glycoside monograph — the full record covers uses, side effects and every documented interaction.

Read the full Koch's Glycoside monograph & all interactions
Medication

About Clomipramine

What Is Clomipramine Used For?

Brand names: Anafranil, Anafranil SR

Clomipramine — sold as Anafranil and under the generic name Clomipramine Hydrochloride — is approved to treat obsessions and compulsions in people with Obsessive-Compulsive Disorder (OCD). This includes adults and children/adolescents ages 10 to 17.

To qualify for treatment, the obsessions or compulsions must cause significant distress, take up a lot of time, or noticeably interfere with work, school, or social life.

See full Clomipramine drug information
Keep checking

Other Drugs & Koch's Glycoside

Browse every other medication we’ve checked against Koch's Glycoside — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Koch's Glycoside against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Koch's Glycoside list.

See the full Koch's Glycoside interactions page
See every supplement checked against Clomipramine, ranked by severity
Evidence & sources

Koch's Glycoside References

The 4 sources that drive our Koch's Glycoside monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Koch's Glycoside is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source
  3. Herbal Supplements — MedlinePlus Source
  4. Health Fraud Scams — U.S. Food and Drug Administration (FDA) Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Koch's Glycoside and Clomipramine Together: Common Questions

Is it safe to take Koch's Glycoside with Clomipramine?
We do not list a known interaction between Koch's Glycoside and Clomipramine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Koch's Glycoside and Clomipramine at the same time of day?
At least one FDA label for a product containing Clomipramine says to take it with food. If you take Koch's Glycoside on an empty stomach out of habit, keep them separate and take Clomipramine with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Clomipramine products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Clomipramine interact with any supplements?
Yes. Clomipramine has documented interactions with 236 supplements in our database — Koch's Glycoside is not one of them. The Clomipramine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Koch's Glycoside monograph Uses, safety profile, and every drug interaction in one place Clomipramine drug information The full plain-English guide to this medication Clomipramine supplement interactions Every supplement checked against Clomipramine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Clomipramine and Koch's Glycoside?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.