Drug & supplement interaction

Lactobacillus Gasseri + Tafenoquine

Tafenoquine brand names: Krintafel, Arakoda.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Lactobacillus Gasseri and Tafenoquine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Tafenoquine states a food rule worth keeping to.

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Interaction report

Lactobacillus Gasseri and Tafenoquine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tafenoquine and Lactobacillus Gasseri in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Lactobacillus Gasseri safety at a glance

Lactobacillus Gass... overall Use caution Generally well tolerated in healthy adults, but evidence is limited and some people should avoid it.
Pregnancy Use caution Not enough reliable safety data; use only with a doctor's guidance.
Breastfeeding Use caution Limited safety information, so check with your doctor before using.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tafenoquine and Lactobacillus Gasseri? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Tafenoquine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tafenoquine is filed under a single classification — oral drugs. Lactobacillus Gasseri has documented interactions with 1 drug class — the most serious being antibiotic drugs (moderate) — and none of Tafenoquine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Lactobacillus Gasseri Does Interact With Other Medications

Lactobacillus Gasseri has 182 moderate known drug interactions in our database — Tafenoquine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 182 No known interaction 2,648 (incl. Tafenoquine)
Taking anything else?

Check Another of Your Medications Against Lactobacillus Gasseri

Covers the 2,830 medications we’ve checked against Lactobacillus Gasseri. Pick one to open its full report.

What to actually watch for

What Lactobacillus Gasseri Itself Has Been Linked To

This is not an interaction — nothing below involves Tafenoquine. It is the side-effect record for Lactobacillus Gasseri on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Lactobacillus Gasseri, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • A higher chance of infection Worth acting on Additional detail

    “Since Lactobacillus gasseri preparations contain live and active microorganisms, there is some concern that they might cause pathogenic infection in some patients. Some lactobacilli species have been isolated in cases of bacteremia, sepsis, splenic abscess, endocarditis, necrotizing fasciitis, pancreatic necrosis, and meningoencephalitis.”

    Lactobacillus Gasseri · Natural Medicines adverse-effect record, reported in cirrhosis.

    6 sources cited
    1. 107543. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
    2. 110917. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
    3. 110918. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
    4. 110920. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
    5. 110921. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.
    6. 112579. Ramos-Coria D, Canto-Losa J, Carrillo-Vázquez D, Carbajal-Morelos L, Estrada-León R, Corona-Rodarte E. Lactobacillus gasseri liver abscess and bacteremia: a case report. BMC Infect Dis 2021;21(1):518. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Lactobacillus Gasseri — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Tafenoquine’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Tafenoquine column appears here.

How to take them

Some Tafenoquine Products Have a Food Rule — Lactobacillus Gasseri Should Not Break It

At least one FDA label for a product containing Tafenoquine says to take it with food. If you take Lactobacillus Gasseri on an empty stomach out of habit, keep them separate — and take Tafenoquine with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Tafenoquine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.1 ) Regimen Name Timing Dosage Loading regimen For each of the 3 days before travel to a malarious area 200 mg (2 of the 100 mg tablets) once daily for 3 days Maintenance regimen While in the malarious area 200 mg (2 of the 100 mg tablets) once weekly – start 7 days after the last loading regimen dose Terminal prophylaxis regimen In the week following exit from the malarious area 200 mg (2 of

From the Dosage and Administration section of the FDA label we read for Tafenoquine — where that label names a specific product, the instruction is that product's. See the Tafenoquine drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Tafenoquine

This page covers Lactobacillus Gasseri only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tafenoquine page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Tafenoquine page

“Tafenoquine (Krintafel, Arakoda) protects against malaria, including the relapsing kind that hides in the liver, and every supplement known to interact with it threatens the same thing, how much of the pill actually reaches your blood. That deserves genuine care, since a partly absorbed antimalarial can let parasites survive and resurf…”

Reviewed by 2 · Jul 18, 2026

Open the Tafenoquine interaction page

One more smart check

Taking Lactobacillus Gasseri as Part of a Dietary Supplement Product? Check It for Interactions

We hold 852 real supplement products containing Lactobacillus Gasseri, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Lactobacillus Gasseri. Even though Lactobacillus Gasseri itself has no known interaction with Tafenoquine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Lactobacillus Gasseri and Tafenoquine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lactobacillus Gasseri
Top 25%

#311 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tafenoquine
Steady interest

#2,682 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lactobacillus Gasseri reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Lactobacillus Gasseri and Tafenoquine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Lactobacillus Gasseri

What is Lactobacillus Gasseri?

  • Digestive health
  • Weight and belly fat management
  • Vaginal and urinary health
  • Bloating and gut discomfort
  • General immune support

Lactobacillus gasseri is a 'friendly' probiotic bacterium found naturally in the human gut, mouth, and vaginal tract, and in some fermented foods. Early research suggests it may help with digestion, weight management, and vaginal health, but the evidence is limited and far from conclusive. It is generally well tolerated in healthy people, but anyone who is pregnant, breastfeeding, or has a weakened immune system should talk to a pharmacist or doctor first.

Lactobacillus gasseri · Lactobacillaceae · Live bacterial cells (probiotic strain) · Capsules, tablets, powders, fermented dairy products, and combination probiotic supplements

An interaction check asks whether these two react with each other — it does not ask whether Lactobacillus Gasseri is a good idea for someone in your situation. Here is what our Lactobacillus Gasseri record says about it on its own.

Lactobacillus Gasseri: dosing

There is no official standardized dose of L. gasseri. Probiotic amounts are usually measured in colony-forming units (CFUs), and products vary widely.The best approach is to follow the directions on the product label and not exceed the recommended amount.

From our Lactobacillus Gasseri monograph — the full record covers uses, side effects and every documented interaction.

Read the full Lactobacillus Gasseri monograph & all interactions
Medication

About Tafenoquine

What Is Tafenoquine Used For?

Brand names: Krintafel, Arakoda

Tafenoquine is used for two distinct purposes depending on the product. Arakoda and Kodatef are used for malaria prophylaxis — that is, preventing malaria in adults 18 and older who are traveling to or living in areas where malaria is present.

Krintafel is used for the radical cure of Plasmodium vivax malaria — meaning it prevents the malaria parasite from coming back (relapsing) in patients 16 and older who are already being treated with chloroquine for an active P. vivax infection. Krintafel is not used to treat an active malaria attack on its own, and it should only be used alongside chloroquine, not other antimalarials.

Most-Reported Side Effects for Tafenoquine

From FAERS, the FDA’s public side-effect reporting system (70 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Depression 20 reports
Anxiety 18 reports
Post-traumatic stress disorder 15 reports
Anger 14 reports
Nausea 14 reports
See full Tafenoquine drug information
Keep checking

Other Drugs & Lactobacillus Gasseri

Browse every other medication we’ve checked against Lactobacillus Gasseri — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
182Moderate
0Minor
2,647No known interaction
182 Moderate 2,647 No interaction
Moderate

182 interactions

Showing 60 of 182 moderate interactions — see all 182 on the Lactobacillus Gasseri page.

No interaction 2,647 drugs checked — show the list

We also checked Lactobacillus Gasseri against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,647 medications checked with no known interaction — see the full Lactobacillus Gasseri list.

See the full Lactobacillus Gasseri interactions page
See every supplement checked against Tafenoquine, ranked by severity
Evidence & sources

Lactobacillus Gasseri References

The 12 references that drive our Lactobacillus Gasseri monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Ramachandran L, Dontaraju VS, Patel K. Lactobacillus-associated spontaneous bacterial peritonitis in a liver cirrhosis patient on probiotics. Cureus. 2020;12(12):e11896. PubMed
  3. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  4. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  5. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
  6. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
  7. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.
  8. Ramos-Coria D, Canto-Losa J, Carrillo-Vázquez D, Carbajal-Morelos L, Estrada-León R, Corona-Rodarte E. Lactobacillus gasseri liver abscess and bacteremia: a case report. BMC Infect Dis 2021;21(1):518. PubMed
  9. Elikowski W, Malek-Elikowska M, Lisiecka M, Bodora A, Wisniewska K, Oko-Sarnowska Z. Lactobacillus gasseri endocarditis on the aortic valve bioprosthesis - a case report. Pol Merkur Lekarski 2017;43(257):220-223.
  10. Esquibel A, Dababneh AS, Palraj BR. Lactobacillus gasseri causing bilateral empyema. Case Rep Infect Dis 2017;2017:4895619.
  11. Tleyjeh IM, Routh J, Qutub MO, Lischer G, Liang KV, Baddour LM. Lactobacillus gasseri causing Fournier's gangrene. Scand J Infect Dis 2004;36(6-7):501-3. PubMed
  12. Dickgiesser U, Weiss N, Fritsche D. Lactobacillus gasseri as the cause of septic urinary infection. Infection 1984;12(1):14-6. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Lactobacillus Gasseri and Tafenoquine Together: Common Questions

Is it safe to take Lactobacillus Gasseri with Tafenoquine?
We do not list a known interaction between Lactobacillus Gasseri and Tafenoquine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Lactobacillus Gasseri and Tafenoquine at the same time of day?
At least one FDA label for a product containing Tafenoquine says to take it with food. If you take Lactobacillus Gasseri on an empty stomach out of habit, keep them separate and take Tafenoquine with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Tafenoquine products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Lactobacillus Gasseri and Tafenoquine combination checked?
Interactions in our licensed database are recorded against drug classes. Tafenoquine is filed under 1 classification, and Lactobacillus Gasseri has documented interactions with 1 drug class — none of Tafenoquine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Lactobacillus Gasseri interact with any other medications?
Yes. Lactobacillus Gasseri has 182 documented drug interactions in our database — Tafenoquine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Tafenoquine interact with any supplements?
Yes. Tafenoquine has documented interactions with 17 supplements in our database — Lactobacillus Gasseri is not one of them. The Tafenoquine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Lactobacillus Gasseri monograph Uses, safety profile, and every drug interaction in one place Tafenoquine drug information The full plain-English guide to this medication Tafenoquine supplement interactions Every supplement checked against Tafenoquine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 12 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tafenoquine and Lactobacillus Gasseri?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.